The Imaging Response Assessment Core (IRAC):
- The primary objective is to facilitate the use of anatomical and molecular imaging methods for assessment of tumor biology and response to therapeutic interventions in cancer clinical trials.
- Services include protocol development and review, specification of imaging parameters to be used in clinical trials, coordinator support of imaging studies to ensure protocol compliance, quality control of images, and qualitative and quantitative analysis of the resultant imaging studies.
- IRAC will investigate novel software tools for image evaluation.
- IRAC will maintain data repositories that permit imaging data to be used for secondary studies.
- IRAC will integrate new, advanced image analysis methods into the tumor imaging and measurement .service, e.g., tumor volumetric measurement and newer PET radiopharmaceuticals.
- Expert advice on how to integrate imaging into research study designs and protocol development.
- Assistance in identifying the image response assessment criteria and personnel support.
- Maintenance of site qualification for cooperative group and industry-sponsored multicenter clinical trials.
- Services required for execution of specialized imaging examinations.
- Coordination of activities and reporting, including data management and routing to appropriate workflow lists.
- Measurement of tumor response by a trained radiologist/nuclear medicine physician or by a trained. technologist with oversight and sign-off by an IRAC radiologist/nuclear medicine physician.
Standard measurements include:
- RECIST or WHO measurements for CT and MRI, including functional measurements (e.g., Choi, mRECIST, EASL, ADC measurements on diffusion-weighted MRI).
- Qualitative and quantitative (e.g., standardized uptake value [SUV]) assessments for PET studies (including EORTC, PERCIST, Cheson, and London/Deauville criteria).
- Advanced analyses for PET/CT or PET/MRI studies.
Data sharing/management services include:
- Routing of image data both to internal servers and to external core facilities.
- Enforcement/adherence to HIPAA regulations.
- Processes to track and de-identify data.
- Access to the RSNA MIRC as a data collection node, which can export de-identified data.
- Capabilities to export image sets in jpg format from any iSite® client.
- Conversions of image formats, e.g., the DICOM-to-jpg conversion necessary for submission to caIMAGE.
- Data transfer to NCI and other sites to enable rapid data access and sharing.
Note: Additional detail, contact Lora Gallagher at IRAC@mir.wustl.edu