PET-RTRC

Projects

Technology Research & Development (TR&D)

The goal of each TR&D project is to develop new PET radiotracers that will image biologic targets modulating the ubiquitous disease processes of inflammation and oxidative stress.

  • Translating S1P1 ligand 11C-TZ3321 into initial human evaluations for safety and efficacy
  • Completing in vivo characterization of 18F-labeled new and selective tracer pharmaceutical properties in inflammatory diseases animal models

Co-leaders: Zhude Tu, PhD, and Robyn S. Klein, MD, PhD

Applications: Multiple sclerosis, atherosclerosis, acute and chronic liver and lung injury, diabetes, cancer, rheumatoid arthritis, inflammatory bowel disease and others

  • Translating a broad spectrum chemokine receptor imaging agent using viral inflammatory macrophage protein-II (64Cu-DOTA-vMIP-II) to determine the overall expression of chemokine receptors in head and neck cancer patient
  • Focusing a chemokine CC receptor 2 (CCR2) targeted PET radiotracer using a peptide ECL1 inverso (64Cu-DOTA-ECL1i)

Co-leaders: Yongjian Liu, PhD, and Robert J. Gropler, MD

Applications: Atherosclerosis, Alzheimer’s disease, inflammatory lung disease and numerous cancers

  • Design, synthesize and validate gallium-68 incorporated PET tracers for imaging ROS-mediated oxidative stress and MPO-driven activity

Co-leaders: Vijay Sharma, PhD, and Kooresh I. Shoghi, PhD

Applications: Prostate cancer, cardiac dysfunction, Parkinson’s disease and pulmonary diseases

Service Projects (SP)

Service Projects (SP) gain access to mature center products otherwise unavailable, providing an opportunity for the advancement of research and newly formed collaborations. 

U.S. Sites

University of Southern California
Non-Small Cell Lung Cancer  

University of California San Francisco
Multiple Sclerosis 

Yale University
Inflammation and Cancer 

Massachusetts General Hospital
Post-MI Remodeling

Washington University School of Medicine
CD36 Function in Immunity and Metabolism
Human Left Ventricular Remodeling 

Icahn School of Medicine at Mount Sinai
Atherosclerosis 

University of North Carolina
Infectious Disease 

Oregon Health & Science University
Pancreatic Cancer

University of Pennsylvania
Neuroinflammation

The University of Texas Southwestern Medical Center
Liver Cancer 

International Sites

Eindhoven University
Atherosclerosis 

To participate, please complete the Service Project Application and email it to Michelle Hoelscher.

Collaborative Projects (CP)

Collaborative Projects (CPs) work in conjunction with TR&Ds, expediting the translational timeline through comprehensive preclinical evaluation of the radiotracers in development.

U.S. Sites

University of Illinois at Urbana-Champaign
Breast Cancer   

The University of Iowa
Cystic Fibrosis 

Massachusetts General Hospital
Liver Fibrosis

Washington University School of Medicine
Abdominal Aortic Aneurysm
Left Ventricular Remodeling
Parkinson’s Disease
Pulmonary Fibrosis 

Memorial Sloan Kettering Cancer Center
Non-Small Cell Lung Cancer

Oregon Health & Science University
Atherosclerosis

International Sites

Hannover Medical School
Left Ventricular Hypertrophy

To propose a project, please complete the Collaborative Projects Application and email it to Michelle Hoelscher.