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PET-RTRC

Projects

Technology Research & Development (TR&D)

The goal of each TR&D project is to develop new PET radiotracers that will image biologic targets modulating the ubiquitous disease processes of inflammation and oxidative stress.

  • Translating S1P1 ligand 11C-TZ3321 into initial human evaluations for safety and efficacy
  • Completing in vivo characterization of 18F-labeled new and selective tracer pharmaceutical properties in inflammatory diseases animal models

Co-leaders: Zhude Tu, PhD, and Robyn S. Klein, MD, PhD

Applications: Multiple sclerosis, atherosclerosis, acute and chronic liver and lung injury, diabetes, cancer, rheumatoid arthritis, inflammatory bowel disease and others

  • Translating a C-C chemokine receptor type 2 (CCR2) targeted PET radiotracer using a peptide ECL1 inverso (64Cu-DOTA-ECL1i) to monitor the CCR2+ pro-inflammatory macrophage subsets in inflammatory diseases and cancers
  • Developing next generation CCR2 targeted radiotracers to image the pro-inflammatory macrophage subset
  • Developing a scavenger receptor CD163 targeted PET probe to image the tissue-resident anti-inflammatory macrophage subset
  • Tracking the dynamic temporal-spatial distribution of macrophage subsets in vivo along the progression and regression of inflammatory diseases and malignancies using PET

Co-leaders: Yongjian Liu, PhD, and Robert J. Gropler, MD

Applications: Atherosclerosis, Alzheimer’s disease, inflammatory lung disease and numerous cancers

  • Design, synthesize and validate gallium-68 incorporated PET tracers for imaging ROS-mediated oxidative stress and MPO-driven activity

Co-leaders: Vijay Sharma, PhD, and Andrew Gelman, PhD

Applications: Prostate cancer, cardiac dysfunction, Parkinson’s disease and pulmonary diseases

Collaborative Projects (CP)

Collaborative Projects (CPs) work in conjunction with TR&Ds, expediting the translational timeline through comprehensive preclinical evaluation of the radiotracers in development.

To propose a project, please complete the Collaborative Projects Application.

Service Projects (SP)

Service Projects (SP) gain access to mature center products otherwise unavailable, providing an opportunity for the advancement of research and newly formed collaborations. 

To participate, please complete the Service Project Application.

Current Projects

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