The Thorek Lab, also known as the Molecular Radiotherapy + Imaging Laboratory, focuses on research at the intersection of quantitative imaging and targeted therapeutics. Using advanced model systems of disease with noninvasive measures of treatment response, we seek to develop and optimize treatments to inform patient management and to improve outcomes. We apply a modality-agnostic approach, with a strong emphasis on physical and computational methods. The questions we ask are intended to reveal or overcome persistent challenges in the field of cancer treatment and infectious disease characterization, with a collaborative team-science approach.