A coalition of researchers from the Dominantly Inherited Alzheimer Network (DIAN), including those from Mallinckrodt Institute of Radiology (MIR) at Washington University School of Medicine in St. Louis, has published a globally available data resource in Nature to provide an invaluable resource to the Alzheimer’s researcher community.
DIAN is an ongoing, international study focused on autosomal dominant Alzheimer’s disease (ADAD), a rare genetic mutation associated with up to 6% of the early onset cases of the disease. Individuals from families carrying ADAD genes have a 50% chance of inheriting the mutation. The researchers published neuroimaging datasets from the network’s comprehensive and longitudinal studies that combine PET and MRI data from 21 sites around the world and data from a cohort of 533 individuals with a family history of ADAD.
Several MIR faculty and staff were part of this study, including first author Nicole S. McKay, PhD, an instructor in radiology, and senior author Tammie L.S. Benzinger, MD, PhD, professor of radiology. The Benzinger Lab serves as DIAN’s imaging core at the School of Medicine.
Read the full paper in Nature.