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Neuroscience and Precision Psychiatry Lab

Projects

Adolescent Twin Precision Imaging

The goal of this project is to uncover neural signatures of internalizing psychopathology that either predispose an individual to psychopathology and/or co-fluctuate with symptomatology over time.

We are collecting MRI and fMRI data over the course of several months within monozygotic and dizygotic twins who are discordant for internalizing symptoms of psychopathology.

Quantifying the Life Factors Shaping Brain Development

The goal of this project is to use Big Data, specifically the Adolescent Brain Cognitive Development (ABCD) Study (N=11,878, 9-11 yo) to quantify the association strength and neurobiology of hundreds of life factors relevant to brain development, including socioeconomics, screens, sleep, cognition, and psychopathology.

We are using advanced statistical models (e.g., mixed effects models, multivariate machine learning techniques) towards reproducible and generalizable models of links between brain development and many life factors.

Sleep and Brains Treatment Study

The goal of this project is to promote our understanding of the neurobiology underlying associations between sleep and psychopathology within individuals in the context of a behavioral sleep intervention.

Our lab has partnered with a children’s sleep clinic, run by Dr. Kendra Krietsch, to gather MRI data, sleep data (actigraphy), and behavioral questionnaires in children undergoing treatment for poor sleep. We are gathering this data within individuals prior to, during, and post sleep intervention to track concurrent changes in sleep quality, functional brain networks, and psychopathology symptoms.

Scott Marek, PhD, points to a brain image on a screen and discusses a project with members of his lab.

Our People

The lab, led by Scott Marek, PhD, leverages multidisciplinary expertise in the areas of radiology, neuroscience, psychiatry and engineering to promote a more reproducible and generalizable program of research towards ultimate clinical translation.

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