Marcus E. Raichle, MD
Alan A. and Edith L. Wolff Distinguished Professor of Medicine
Professor of Radiology, Neurology, Neurobiology and Biomedical Engineering
Research Centers:Neuroimaging Labs Research Center
Marcus E. Raichle, MD, is the Alan A. and Edith L. Wolff Distinguished Professor of Medicine and a researcher in the Neuroimaging Labs Research Center for Mallinckrodt Institute of Radiology at Washington University School of Medicine in St Louis. Raichle, who previously served as head of the Neuroimaging Labs Research Center, is a trailblazer in the study of human brain function through the development and use of positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). He and his colleagues’ landmark study described the first integrated strategy for the design, execution and interpretation of functional brain images.
Another seminal study led to the discovery that blood flow and glucose utilization change more than oxygen consumption in the active brain causing tissue oxygen to vary with brain activity. Finally seeking to explain task-induced activity decreases in functional brain images, Raichle’s team employed an innovative strategy to define a physiological baseline. This led to the concept of a default mode of brain function and invigorated studies of intrinsic functional activity, an issue largely dormant for more than a century. An important facet of this work was the discovery of a unique fronto-parietal network in the brain that has come to be known as the default network. This network is now the focus of work on brain function in health and disease worldwide.
normal human brain function, functional brain imaging signals biological origins
Link to Publications
American Academy of Arts and Sciences
American Neurological Association
National Academy of Science (Institute of Medicine)
National Academy of Sciences
Editorial Board, Proceedings of the National Academy of Sciences