Cyclotron Facility

Cyclotron Facility User’s Publications

1. Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D, Sutphen CL, Benzinger TLS,  Mintun MA, Holtzman DM, Morris JC.  Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology. 2013;80(19):1784-91. Epub 2013/04/12. doi: 10.1212/WNL.0b013e3182918ca6. PubMed PMID: 23576620; PubMed Central PMCID: PMC3719431

2. Su Y, D'Angelo GM, Vlassenko AG, Zhou G, Snyder AZ, Marcus DS, Blazey TM, Christensen JJ, Vora S, Morris JC, Mintun MA, Benzinger TL. Quantitative analysis of PiB-PET with FreeSurfer ROIs. PLoS One. 2013;8(11):e73377. PubMed PMID: 24223109; PubMed Central PMCID: PMC3819320

3. Wang L, Brier MR, Snyder AZ, Thomas JB, Fagan AM, Xiong C, Benzinger TL, Holtzman DM, Morris JC, Ances BM. Cerebrospinal Fluid Abeta42, Phosphorylated Tau181, and Resting-State Functional Connectivity. JAMA neurology. 2013. Epub 2013/08/21. doi: 10.1001/jamaneurol.2013.3253. PubMed PMID: 23959173, PMCID: in progress.

4. Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, Mawuenyega K, Blazey T, Goate A, Chott R, Yarasheski KE, Holtzman DM, Morris JC, Benzinger TL, Bateman RJ.  Increased in vivo amyloid-beta42 production, exchange, and loss in presenilin mutation carriers. Science translational medicine. 2013;5(189):189ra77. Epub 2013/06/14. doi: 10.1126/scitranslmed.3005615. PubMed PMID: 23761040, PMCID: in process

5. Su Y, Arbelaez AM, Benzinger TL, Snyder AZ, Vlassenko AG, Mintun MA, Raichle ME.  Noninvasive estimation of the arterial input function in positron emission tomography imaging of cerebral blood flow. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013;33(1):115-21. Epub 2012/10/18. doi: 10.1038/jcbfm.2012.143. PubMed PMID: 23072748; PubMed Central PMCID: PMC3597366

6. Su Y, D'Angelo GM, Vlassenko AG, Zhou G, Snyder AZ, Marcus DS, Blazey TM, Christensen JJ, Vora S, Morris JC, Mintun MA, Benzinger TL. Quantitative Analysis of PiB-PET with FreeSurfer ROIs. PLoS One. 2013;8(11):e73377. doi: 10.1371/journal.pone.0073377. PubMed PMID: 24223109; PubMed Central PMCID: PMCJournal - In Process


1. The role of p53 in combination radioimmunotherapy with 64Cu-DOTA-cetuximab and cisplatin in a mouse model of colorectal cancer. Guo Y, Parry JJ, Laforest R, Rogers BE, Anderson CJ. J Nucl Med. 2013 Sep;54(9):1621-9. doi: 10.2967/jnumed.112.118539. Epub 2013 Jul 19. PMID:23873478

2. Copper-64 radiolabeling and biological evaluation of bifunctional chelators for radiopharmaceutical development. De Silva RA, Jain S, Lears KA, Chong HS, Kang CS, Sun X, Rogers BE. Nucl Med Biol. 2012 Nov;39(8):1099-104. doi: 10.1016/j.nucmedbio.2012.05.009. Epub 2012 Jun 27. PMID:22743158

3. In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer. Craft JM, DeSilva RA, Lears KA, Andrews R, Liang K, Achilefu S, Rogers BE. Nucl Med Biol. 2012 Jul;39(5):609-16. doi: 10.1016/j.nucmedbio.2011.12.004. Epub 2012 Jan 20. PMID:22261146

4. Pathway-specific analysis of gene expression data identifies the PI3K/Akt pathway as a novel therapeutic target in cervical cancer. Schwarz JK, Payton JE, Rashmi R, Xiang T, Jia Y, Huettner P, Rogers BE, Yang Q, Watson M, Rader JS, Grigsby PW. Clin Cancer Res. 2012 Mar 1;18(5):1464-71. doi: 10.1158/1078-0432.CCR-11-2485. Epub 2012 Jan 10. PMID:22235101

5. Evaluation of copper-64-labeled somatostatin agonists and antagonist in SSTr2-transfected cell lines that are positive and negative for p53: implications for cancer therapy. Nguyen K, Parry JJ, Rogers BE, Anderson CJ. Nucl Med Biol. 2012 Feb;39(2):187-97. doi: 10.1016/j.nucmedbio.2011.08.006. Epub 2011 Nov 4. PMID:22056254


1. Grubb RL Jr, Clarke WR, Adams H, Videen TO, Derdeyn CP, Powers WJ for the COSS investigators.  Surgical Results of the Carotid Occlusion Surgery Study. Journal of Neurosurgery 2013 118:25-33.

2. Vakil P, Lee JJ, Mouannes-Srour JJ, Derdeyn CP, Carroll TJ.  Quantitative DSC-MRI derived Cerebral Blood Flow Correlates with Quantitative H2[O]15 – PET in Cerebrovascular Occlusive Disease.  Radiology 2013 266:879-86. PMID: 23297337

3. Powers WJ, Clarke WR, Grubb RL Jr, Videen TO, Adams H, Derdeyn CP, for the COSS investigators. No Higher Stroke Risk with Lower Blood Pressures in Hemodynamic Cerebral Ischemia.  Neurology. 2014 Feb 14. [Epub ahead of print]  PMID: 24532276

4. Marshall RS, Festa JR, Cheung Y-K, Pavol MA, Derdeyn CP, Clarke WR, Videen TO, Grubb RL, Slane K, Powers WJ, Lazar RM. The Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON) Trial: Main Results. Neurology 2014  [Epub ahead of print] PMID:24477109

5. Reynolds MR, Kamath AA, Grubb RL Jr, Powers WJ, Adams HP Jr, Derdeyn CP for the COSS Investigators.  The Safety of Airplane Travel in Patients with Symptomatic Carotid Occlusion.  Journal of Neurology, Neurosurgery and Psychiatry  2013 [epub ahead of print] PMID 24249780


1. Dhar R, Scalfani MT, Blackburn S, Zazulia AR, Videen T, Diringer M. Relationship between angiographic vasospasm and regional hypoperfusion in aneurysmal subarachnoid hemorrhage. Stroke 2012; 43: 1788-94.

Hershey and Arbelaez

1. Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T (2013). A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[11 C]methyl)benperidol. Synapse; 67(11): 748-56. PMCID: PMC3778147

2. Arbeláez AM, Su Y, Jewel T, Cryer PE, Hershey T, Ances BM (2013). Comparison of regional cerebral blood flow response to hypoglycemia using pulsed arterial spin labeling and positron emission tomography.  PLoS One; 8(3): e60085. PMCID: PMC3610825


1. Kotagiri N, Niedzwiedzki DM, Ohara K, Achilefu S. Activatable probes based on distance-dependent luminescence associated with Cerenkov radiation. Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7756-60.


1. Chang, A.J., DeSilva, R, Lapi, S.E. (2013) Development and Characterization of 89Zr-labeled Panitumumab for ImmunoPET Imaging of the EGF Receptor,  Molecular Imaging, 12(1), 17-27

2. Mebrahtu, E., Zheleznyak, A, Hur, M., Lapi, S.E.(2013) Initial characterization of a dually radiolabeled peptide for simultaneous monitoring of protein targets and enzymatic activity  Nuclear Medicine and Biology 40(2), 190-6

3. Chang, A.J., Sohn, R., Lu, Z. H., Arbeit, J.A., Lapi, S.E. (2013) Detection of rapalog-mediated therapeutic response in renal cancer xenografts using 64Cu-bevacizumab ImmunoPET PLoS One 8(3):e58949

4. Richards, V., Mebrahtu, E., Lapi, S.E. (2013) Cyclotron Production of 99mTc using 100Mo2C targets Nuclear Medicine and Biology 40(7), 939-45

5. Knight, J.C., Wuest, M., Saad, F.A., Wang, M., Chapman, D.W., Jans, H.S., Lapi, S.E., Kariuki, B.M., Amoroso, A.J., Wuest, F.  (2013) Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions Dalton Trans. 42(33):12005-14

6. Wooten, A.L., Madrid, E., Schweitzer, A.D., Lawrence, L.A., Mebrahtu, E., Lewis, B.C. Lapi, S.E. (2013)  Routine Production of 89Zr Using an Automated Module Applied Science 3(3): 593-613
7. Ikotun, O.F., Marquez, B.V., Huang, C., Masuko, K., Daiji, M., Masuko, T., McConathy, J.E., Lapi, S.E. (2013) Imaging the L-type Amino Acid Transporter-1 (LAT1) with Zr-89 ImmunoPET PLoS ONE 8(10):e77476

8. Zheleznyak, A., Ikotun, O.F., Dimitry, J., Frazier, W.A., Lapi, S.E. (2013) Imaging of CD47 Expression in Xenograft and Allograft Tumor Models Molecular Imaging  12(8):525-34.

9. Marquez, B.V., Ikotun, O.F., Parry, J.J., Rogers, B.E., Meares, C.F., Lapi, S.E. (2014) Development of a Radiolabeled Irreversible Peptide Ligand for PET imaging of VEGF Journal of Nuclear Medicine in press


1. Eric Pressly, Rich Pierce, Luke A Connal, Craig J. Hawker, Yongjian Liu. Nanoparticle PET/CT Imaging of Natriuretic Peptide Clearance Receptor in Prostate Cancer. Bioconjugate Chemistry, 2013, 24, 196-204. PMCID: PMC3578065.
2. Aida Ibricevic, Sean P. Gunsten, Ke Zhang, Ritu Shrestha, Yongjian Liu, Jing Yi Sun, Michael J. Welch, Karen L. Wooley, Steven L. Brody. PEGylation of Cationic, Shell-crosslinked-knedel-like Nanoparticles Modulates Inflammation and Enhances Cellular Uptake in the Lung. Nanomedicine, 2013, 9, 912-922. PMID: 23453959.
3. Yucai Wang, Kvar C.L. Black, Hannah Luehmann, Weiyang Li, Yu Zhang, Xin Cai, Dehui Wan, Si-Yun Liu, Max Li, Paul Kim, Zhi-Yuan Li, Lihong V. Wang, Yongjian Liu, Younan Xia.  Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment. ACS Nano, 2013, 7, 2068-2077. PMCID: PMC3609935.

4. Ziyan Zhang, Yongjian Liu, Chad Jarreau, Michael J. Welch, John-Stephen A. Tylor. Nucleic Acid-directed Self-assembly of Multifunctional Gold Nanoparticle Imaging Agents. Biomaterials Science, 2013, 1, 1055-1064. PMID: 24058728.

5. Yuefei Shen, Ritu Shrestha, Aida Ibricevic, Sean P. Gunsten, Michael J. Welch, Karen L. Wooley, Steven L. Brody, John-Steven A. Taylor, Yongjian Liu. Antisense Peptide Nucleic Acid-functionalized Cationic Nanocomplex for In Vivo mRNA Detection. Interface Focus. 2013, 3, 20120059. PMID: 24427537.
6. Yongjian Liu, Richard Pierce, Hannah Luehmann, Terry L. Sharp, Michael J. Welch. Positron Emission Tomography Imaging of Chemokine Receptors in Vascular Injury Accelerated Atherosclerosis. Journal of Nuclear Medicine, 2013, 54, 1135-1141. PMID: 23658218.
7. Yongfeng Zhao, Deborah Sultan, Lisa Detering, Sangho Cho, Guorong Sun, Richard Pierce, Karen L. Wooley, Yongjian Liu. Copper-64-Alloyed Gold Nanoparticles for Cancer Imaging: Improved Radiolabel Stability and Diagnostic Accuracy. Angewandte Chemie International Edition. 2014, 53, 156-159. PMID: 24272951.


1.  Fowler KJ, McConathy J, Narra VR. Whole-body simultaneous positron emission tomography (PET)-MR: optimization and adaptation of MRI sequences. J Magn Reson Imaging. 2014;39:259-268. 10.1002/jmri.24308.

2. Ferguson A, McConathy J, Su Y, Hewing D, Laforest R. Attenuation Effects of MR Headphones During Brain PET/MR Studies. Journal of nuclear medicine technology. 2014. 10.2967/jnmt.113.131995.

3. Conway CR, Chibnall JT, Cumming P, Mintun MA, Gebara MA, Perantie DC, Price JL, Cornell ME, McConathy JE, Gangwani S, Sheline YI. Antidepressant response to aripiprazole augmentation associated with enhanced FDOPA utilization in striatum: A preliminary PET study. Psychiatry research. 2014. 10.1016/j.pscychresns.2014.01.003.

4.  Sai KK, Huang C, Yuan L, Zhou D, Piwnica-Worms D, Garbow JR, Engelbach JA, Mach RH, Rich KM, McConathy J. 18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas. J Nucl Med. 2013;54:1120-1126. 10.2967/jnumed.112.113217, PMC3766958.

5.   Ikotun OF, Marquez BV, Huang C, Masuko K, Daiji M, Masuko T, McConathy J, Lapi SE. Imaging the L-type amino acid transporter-1 (LAT1) with Zr-89 immunoPET. PLoS One. 2013;8:e77476. 10.1371/journal.pone.0077476, PMC3797081.

6.  Huang C, Yuan L, Rich KM, McConathy J. Radiosynthesis and biological evaluation of alpha-[F-18]fluoromethyl phenylalanine for brain tumor imaging. Nucl Med Biol. 2013;40:498-506. 10.1016/j.nucmedbio.2012.12.013, PMC3644424.


1. Bagchi D, Yu L, Perlmutter JS, Xu J, Mach R, Tu Z, Kotzbauer P, “Binding of the Radioligand SIL234 to alpha-synuclein fribrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.” PLoS One 8(2), e55031, 2013. PMCID: PMC3566091.

2. Xu J, Vangveravong S, Li S, Fan J, Jones L, Cui J, Wang R, Tu Z, Chu W, Perlmutter JS, Mach R. Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist. Neuroimage 71:168-174, 2013. PMID:
3. 23333701 [PubMed - in process].

4. Karimi MK, Tian L, Brown CA, Flores HP, Loftin SK, Videen TO, Moerlein SM, Perlmutter JS: Validation of nigrostriatal positron emission tomorgraph measures: critical limits.  Ann Neurol 73:390-6, 2013. PMCID: PMC3631302.

5. Campbell MC, Markham J, Flores H, Hartlein J, Goate A, Cairns NJ, Videen TO, Perlmutter JS. Principal component analysis of PiB Distribution in Parkinson and Alzheimer diseases. Neurology 2013 Jul 3. [Epub ahead of print]

6. Eisenstein SA, Antenor-Dorsey JV, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbelaez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T.  A comparison of D2 Receptor Specific binding in Obese and normal weight indivdiuals using PET with (N-[11C]methyl)benperidol. Synapse May 6, 2013 [Epub ahead of print].

7. Brown CA, Karimi MK, Tian L, Flores H, Su Y, Tabbal SD, Loftin SK, Moerlein SM, Perlmutter JS.  Validation of midbrain PET measures for nigrostriatal neurons in macaques. Ann Neurol May 20, 2013 [Epub ahead of press].

8. Li J; Zhang X; Zhang Z; Padakanti P; Jin H; Cui J; Li A; Zeng D; Rath N; Flores H; Perlmutter JS; Parsons S; Tu, Z. Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter. J Med Chem 2013 Jun 26. [Epub ahead of print]

9. Karimi M, Moerlein SM, Videen TO, Flores HP, Perlmutter JS. Normal striatal D1-like receptor binding in primary focal dystonia. Mov Disord. 28: 2002-6, 2013

10. Black KJ, Snyder AZ, Mink JW, Tolia VN, Revilla FJ, Moerlein SM, Perlmutter JS. Spatial reorganization of putamninal dopamine-D2-like receptors in cranial and hand dystonia. PLoS One Feb 10;9(2):e88121, 2014.


1. Lyons MR, Peterson LR,  McGill JB, Herrero P, Coggan A, Saeed IM, Recklein C, Schechtman KB, Gropler RJ.  Impact of sex on the heart’s metabolic and functional responses to diabetic therapies. Am J Physiol 2013, 305(11):H1584-91.


1.       Lamb J, Robinson C, Bradley J, Laforest R, Dehdashti F, White B, Wuenschel S, Low D.  “Generating Internal Target Volumes for Lung Tumors from 4D-PET Maximum Intensity Projections” Med Phys. 38(10):5732-5737, 2011.

2.   Jani S, Robinson C, Dahlbom M, White B, Thomas D, Gaudio S, Low D, Lamb J.  “A Comparison of Amplitude-Based and Phase-Based Positron Emission Tomography Gating Algorithms for Segmentation of Internal Target Volumes of Tumors Subject to Respiratory Motion” Int. J Rad Onc Biol Phys 87(3):562-569, 2013.

3.       Lamb J*, Robinson C*, Bradley J, Low D. “Motion-Specific Internal Target Volumes for FDG-Avid Mediastinal and Hilar Lymph Nodes.” Radiother Oncol 2013 – in press *Authors contributed equally to this manuscript.

4.       Valdes G, Robinson C, Lee P, Morel D, Low D, Iwamoto K, Lamb J. “Utility of 4D vs 3D dose calculations on stereotactic and fractionated radiotherapy treatment planning of lung cancer.” [Submitted to Radiother Oncol]

5.       Lamb J, Robinson C, Low D. “A Method for Deformable Image Registration Quality Assurance Using Matched PET-CT Image Pairs” [Submitted to Int J Radiat Oncol Biol Phys]


1. Jiang, M.; Ferdani, R.; Shokeen, M. and Anderson, C.J.  “Comparison of two cross-bridged macrocyclic chelators for the evaluation of 64Cu-labeled-LLP2A, a peptidomimetic ligand targeting VLA-4-positive tumors” Nucl Med Biol 2013, 40(2): 245-51. PMID: 23265977

2. Soodgupta, D.; Hurchla, M. A.; Jiang, M.; Zheleznyak, A.; Weilbaecher, K. N.; Anderson, C. J.; Tomasson, M. H.*; Shokeen, M.*, “Very late antigen-4 (alpha(4)beta(1) Integrin) targeted PET imaging of multiple myeloma” PLoS One 2013, 8(2): e5584. PMID: 23409060 (*Corresponding author)

3. Shokeen, M.; Zheleznyak, M.; Wilson, J. M.; Jiang, M.; Liu, R.; Ferdani, R.; Lam, K.; Schwarz, JK; Anderson, C. J., “Molecular Imaging of Very Late Antigen-4 (α4β1 integrin) in the Pre-Metastatic Niche.” Journal of Nuclear Medicine (JNM) 2012, 53(2): 779-86. PMID: 22496586

Siegel and Dehdashti
1. Creach KM, Nussenbaum B, Siegel BA, Grigsby PW.  Thyroid carcinoma uptake of 18F-fluorodeoxyglucose in patients with elevated serum thyroglobulin and negative 131I scintigraphy.  Am J Otolaryngol 2013; 34:51-56.
2. Kidd EA, Thomas M, Siegel BA, Dehdashti F, Grigsby PW. Changes in cervical cancer FDG uptake during chemoradiation and association with response. Int J Radiat Oncol Biol Phys 2013; 85:116-122. PMCID:PMC3404156
3. Dehdashti F, Grigsby PW, Myerson RJ, Nalbantoglu I, Ma C, Siegel BA. Positron emission tomography with [18F]-3'-deoxy-3'-fluorothymidine (FLT) as a predictor of outcome in patients with locally advanced resectable rectal cancer: a pilot study. Mol Imaging Biol 2013; 15:106-113. PMCID:PMC3659775
4. Olsen JR, Esthappan J, DeWees T, Narra VR, Dehdashti F, Siegel BA, Schwarz JK, Grigsby PW. Tumor volume and subvolume concordance between FDG-PET/CT and diffusion-weighted MRI for squamous cell carcinoma of the cervix. J Magn Reson Imaging 2013; 37:431-434. PMCID:PMC3541467
5. Adkins D, Ley J, Trinkaus K, Thorstad W, Lewis J Jr, Wildes T, Siegel BA, Dehdashti F, Gay H, Mehan P, Nussenbaum B. A phase 2 trial of induction nab-paclitaxel and cetuximab given with cisplatin, and 5-fluorouracil followed by concurrent cisplatin and radiation for locally advanced squamous cell carcinoma of the head and neck: a phase II prospective trial. Cancer 2013; 119:766-773. PMCID:PMC3832987
6. Chang AJ, Dehdashti F, Siegel BA, Welch MJ, Schwarz JK, Grigsby PW. Intratumoral heterogeneity of 64Cu-ATSM uptake is a prognostic indicator in patients with cervical cancer.  OMICS J Radiol 2013; 2:e130.
7. Haseebuddin M, Dehdashti F, Siegel BA, Liu J, Roth EB, Nepple KG, Siegel CL, Fischer KC, Kibel AS, Andriole GL, Miller TR. 11C-acetate PET/CT before radical prostatectomy: nodal staging and treatment failure prediction. J Nucl Med 2013; 54:699-706. PMCID:PMC3787881
8. Itti E, Meignan M, Berriolo-Riedinger A, Biggi A, Cashen AF, Véra P, Tilly H, Siegel BA, Gallamini A, Casanovas RO, Haioun C. An international confirmatory study of the prognostic value of early PET/CT in diffuse large B-cell lymphoma: comparison between Deauville criteria and ΔSUVmax. Eur J Nucl Med Mol Imaging 2013; 40:1312-1320.
9. Machtay M, Duan F, Siegel BA, Snyder BS, Gorelick JJ, Reddin JS, Munden R, Johnson DW, Wilf LH, DeNittis A, Sherwin N, Cho KH, Kim S, Videtic G, Neumann DR, Komaki R, Macapinlac H, Bradley JD, Alavi A. Prediction of survival by [18F]fluorodeoxyglucose positron emission tomography in patients with locally advanced non-small-cell lung cancer undergoing definitive chemoradiation therapy: results of the ACRIN 6668/RTOG 0235 trial. J Clin Oncol 2013; 31:3823-3830. PMCID:PMC3795891
Tomlinson, Shoghi, Silvia
1.  Tomlinson R.E., Shoghi K., Silva M. J. Nitric Oxide Mediated Vasodilation Increased Blood Flow During the Early Stages of Stress Fracture Healing. Article in press J. Appl Physiol December 19 2013, dio 10.1152/applphysiol.00957.2013

1. Synthesis, [(18)F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem. 2014 Mar 1;22(5):1700-7. doi: 10.1016/j.bmc.2014.01.019. Epub 2014 Jan 24