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Radiological Chemistry and Imaging Laboratory (RCIL)

TuHeadshot2 150pixel

Zhude Tu

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:
2213A East Building
(314) 362-8487

zhudetu@wustl.edu

Current Position
Professor of Radiology
 

Research Interests
Our research is focused on the development and validation of PET radiopharmaceuticals for quantifying receptors, enzymes and transporters in the central nervous system (CNS). These imaging agents are used for diagnosing early-stage neurological disorders and assessing disease progression, as well as monitoring the therapeutic efficacy of treatment for CNS disorders including Alzheimer disease, Parkinson’s disease, Huntington’s disease and schizophrenia.

  • Translational studies of a PET tracer for VAChT as a marker of cholinergic function
  • Novel PET tracers for PDE10A in neuropsychiatric and neurodegenerative diseases
  • Radioligands for alpha- synuclein imaging
  • Radioligands for imaging sphingosine 1 phosphate receptors in inflammation
     

Key Publications:

  1. Liu H, Jin H, Yue X, Han J, Baum P, Abendschein DR, Tu Z. PET study of sphingosine-1-phosphate receptor 1 expression in response to vascular inflammation in a rat model of carotid injury. Mol Imaging.16:1-7. (epub: January 30, 2017) doi.org/10.1177/1536012116689770. (2017)
  2. Liu H, Jin H, Yue X, Luo Z, Liu C, Rosenberg AJ, Tu Z. PET imaging study of S1PR1 expression in a rat model of multiple sclerosis. Mol Imaging Biol. PMID: 26975859. doi:10.1007/s11307-016-0944-y. (2016)
  3. Tu Z, Zhang X, Jin H, Yue X, Padakanti PK, Yu L, Liu H, Flores HP, Kaneshige K, Parsons SM, Perlmutter JS. Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter. Bioorg Med Chem.23(15):4699-709. PMC4524497. (2015)
  4. Liu H, Jin H, Yue X, Zhang X, Yang H, Li J, Flores H, Su Y, Perlmutter JS, Tu Z. Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject. Neuroimage.121:253-62. PMC4604036. doi:10.1016/j.bmc.2015.05.058. (2015)
  5. Li J, Zhang X, Zhang Z, Padakanti PK, Jin H, Cui J, Li A, Zeng D, Rath NP, Flores H, Perlmutter JS, Parsons SM, Tu Z. Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter. J Med Chem.56(15):6216-33. PMC3804129. doi:10.1021/jm400664x. (2013).