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Radiological Chemistry and Imaging Laboratory (RCIL)

Dong Zhou

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:
4424E Clinical Sciences Research Building
(314) 362-9072
zhoud@mir.wustl.edu

Current Position
Instructor in Radiology
 

Research Interests
My research focuses on fluorine-18 radiochemistry and development of novel PET tracers for preclinical and clinical applications.

  • New method development for fluorine-18 labeling
  • Novel PET tracer development for imaging of targets with clinical relevance
  • Translation and optimization of labeling methods for automated production
     

Key Publications:

  1. D. Zhou, W. Chu, J. Rothfuss, C. Zeng, J. Xu, L. Jones, M. J. Welch, R. H. Mach. Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Bioorgan. Med. Chem. Lett. 16(19): 5041, 2006.
  2. D. Zhou, H. Lee, J. M. Rothfuss, D. L. Chen, D. E. Ponde, M. J. Welch, R. H. Mach. Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase. J. Med. Chem. 52(8): 2443, 2009.
  3. A. M. Fowler, S. R. Chan, T. L. Sharp, N. M. Fettig, D. Zhou, C. S. Dence, K. E. Carlson, M. Jeyakumar, J. A. Katzenellenbogen, R. D. Schreiber, M. J. Welch. Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer. J. Nucl. Med. 53(7): 1119, 2012.
  4. D. Zhou, W. Chu, J. Xu, L. A. Jones,X. Peng, S. Li, D. L. Chen, R. H. Mach. Synthesis, [18F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography, Bioorg. Med. Chem. 22(5): 1700, 2014.
  5. W. Chu, A. Chepetan, D. Zhou, K. I. Shoghi, J. Xu, L. L. Dugan, R. J. Gropler, M. A. Mintun, R. H. Mach. Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo. Org. Biomol. Chem. 12(25): 4421, 2014.
     

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