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Radiological Chemistry and Imaging Laboratory (RCIL)

Vijay Sharma

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:
7608 BJC Institute of Health
(314) 362-9358
sharmav@mir.wustl.edu
 

Current Position
Professor of Radiology and Biomedical Engineering
 

Research Interests
My research focuses on employing state-of-the-art rational drug design tools. We are interested in the synthesis of small organic molecules, peptide conjugates, and metalloprobes to interrogate important biological pathways and identify new biomarkers. Other areas of near term interests are to extend the repertoire of our reporter probes into various biological applications via development of novel heterocyclic compounds for imaging reporter gene expression and cancer biology, chemiluminescent substrates for imaging inflammation, and near infrared optical probes for understanding critical disease-specific biochemical mechanism(s)..

  • Chemical and Radiopharmaceutical Synthesis
  • Imaging of Alzheimer's Disease Biomarkers
  • Multidrug Resistance and Blood-Brain Barrier Imaging
  • Myocardial Perfusion Imaging
     

Key Publications:

  1. A generator-produced Gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion.  Sharma V, Sivapackiam J, Harpstrite SE, Prior JL, Gu H, Rath NP, Piwnica-Worms D. PLoS One. 2014 Oct 29;9(10):e109361. PMID: 25353349.
  2. Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice. Sundaram GS, Garai K, Rath NP, Yan P, Cirrito JR, Cairns NJ, Moo-Lee J, Sharma V. Org Lett. 2014 Jul 18;16(14):3640-3. PMID: 25003699
  3. Interrogation of multidrug resistance (MDR1) P-glycoprotein (ABCB1) expression in human pancreatic carcinoma cells: Correlation of 99mTc-Sestamibi uptake with western blot analysis. Harpstrite SE, Gu H, Natarajan R, Sharma V. Nucl Med Commun. 2014 Oct;35(10):1067-70. PMID: 25036383
  4. A new nucleoside analogue with potent activity against mutant sr39 herpes simplex virus-1 (HSV-1) thymidine kinase (TK).Sundaram GS, Harpstrite SE, Kao JL, Collins SD, Sharma V. Org Lett. 2012 Jul 20;14(14):3568-71. PMID: 22765027
  5. Synthesis, molecular structure, and validation of novel metalloprobes for assessment of MDR1 P-glycoprotein-mediated functional transport. Sivapackiam J, Harpstrite SE, Prior JL, Gu H, Rath, NP, Sharma V. Dalton Trans. 2010 Jul 7;39(25):5842-50. PMID: 20505882