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Precision Radio-Theranostics Translational Laboratories (PRT2L)

Stephen Moerlein

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:
1112 East Building
(314) 362-8466
moerleins@wustl.edu 
 

Current Position
Associate Professor of Radiology and Biochemistry
Adjunct Clinical Associate Professor (Saint Louis College of Pharmacy)
 

Research Interests
My research focuses is on development, translation and clinical application of PET radiopharmaceuticals, with special emphasis on neurology and oncology..

  • Tracer development and validation using non-human primates
  • Translation of preclinical methodologies to human subjects
  • Clinical production of radiopharmaceuticals
  • Application of novel molecular imaging techniques to specific patient populations
     

Key Publications:

  1. Karimi M, Moerlein SM, Videen TO, Su Y, Flores HP, Perlmutter JS. Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia. Mov Disord. 2013 Dec; 28(14):2002-2026. PMID: 24151192. PMCID: PMC4086787. doi: 10.1002/mds.25720.
  2. Eisenstein SA, Antenor-Dorsey JA, Gredysa DM, Koller JM, Bihun EC, Ranck SA, Arbeláez AM, Klein S, Perlmutter JS, Moerlein SM, Black KJ, Hershey T. A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[(11)C]methyl)benperidol. Synapse. 2013 Nov; 67(11):748-756. PMID: 23650017. PMCID: PMC3778147. doi: 10.1002/syn.21680.3.
  3. Eisenstein SA, Koller JM, Piccirillo M, Kim A, Antenor-Dorsey JA, Videen TO, Snyder AZ, Karimi M, Moerlein SM, Black KJ, Perlmutter JS, Hershey T. Characterization of extrastriatal D2 in vivo specific binding of [¹⁸F](N-methyl)benperidol using PET. Synapse. 2012 Sep; 66(9):770-780. PMID: 22535514. PMCID: PMC3389593. doi: 10.1002/syn.21566.4. 
  4. Criswell SR, Perlmutter JS, Videen TO, Moerlein SM, Flores HP, Birke AM, Racette BA. Reduced uptake of [¹⁸F]FDOPA PET in asymptomatic welders with occupational manganese exposure. Neurology. 2011 Apr 12; 76(15):1296-1301. PMID: 21471467. PMCID: PMC3090062. doi: 10.1212/WNL.0b013e3182152830.
  5. Karimi M, Moerlein SM, Videen TO, Luedtke RR, Taylor M, Mach RH, Perlmutter JS. Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect? Mov Disord. 2011 Jan; 26(1):100-106. Epub 2010 Oct 19. PMID: 20960437. PMCID: PMC3025272. doi: 10.1002/mds.23401.