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Patricia Pereira-web3-2021Jun637599755287180931

Patrícia M. R. Pereira

Contact Information

Washington University School of Medicine

Department of Radiology
CB 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:

Clinical Sciences Research Building

(314) 273 4898

ribeiropereirap@wustl.edu

Current Position

Assistant Professor of Radiology

Research Interests

Ribeiro Pereira Group is focused on preclinical research using multi-imaging modality that aims at modulating the availability of surface targets by elucidating their regulatory mechanisms to enhance antibody- and non-antibody-based tumor therapies. The Ribeiro Pereira Group has four major goals:

  • Use biomolecules, ranging from small molecules to full-length antibodies, as tumor-targeting agents to deliver imaging or cytotoxic cargo
  • Use multimodal imaging to monitor the binding of molecular-targeted compounds to tumors before and during therapy
  • Use acute and temporal pharmacologic approaches to modulate tumor biology in ways that enhance tumor binding of antibody- and non-antibody-based cancer therapies
  • Improve cancer diagnosis and treatment by combining basic tumor biology with preclinical knowledge and clinical needs

Key Publications

  • Pereira PMR, Mandleywala K, Ragupathi A, Lewis JS. Acute Statin Treatment Improves Antibody Accumulation in EGFR- and PSMA-Expressing Tumors. Clin Cancer Res. 2020 Dec 1; 26(23):6215-6229. Epub 2020 Sep 30. doi: 10.1158/1078-0432.CCR-20-1960. PMID: 32998959. Cover image. Article featured in the Highlights of the December Issue.
  • Pereira PMR, Norfleet J, Lewis JS, Escorcia FE. Immuno-PET Detects Changes in Multi-RTK Tumor Cell Expression Levels in Response to Targeted Kinase Inhibition. J Nucl Med. 2021 Mar; 62(3):366-371. Epub 2020 Jul 9. doi: 10.2967/jnumed.120.244897. PMID: 32646879; PMCID: PMC8049345. Cover image. March featured article of the month.
  • Pereira PMR, Parada B, Ribeiro-Rodrigues TM, Fontes-Ribeiro CA, Girão H, Tomé JPC, Fernandes R. Caveolin-1 Modulation Increases Efficacy of a Galacto-Conjugated Phthalocyanine in Bladder Cancer Cells Resistant to Photodynamic Therapy. Mol Pharm. 2020 Jun; 17(6):2145-2154. doi: 10.1021/acs.molpharmaceut.0c00298. PMID: 32339462.
  • Pereira PMR, Edwards KJ, Mandleywala K, Carter LM, Escorcia FE, Campesato LF, Cornejo M, Abma L, Mohsen AA, Iacobuzio-Donahue CA, Merghoub T, Lewis JS. iNOS Regulates the Therapeutic Response of Pancreatic Cancer Cells to Radiotherapy. Cancer Res. 2020 Apr; 80(8):1681-1692. doi: 10.1158/0008-5472.CAN-19-2991. PMID: 32086240; PMCID: PMC7165066.
  • Pereira PMR, Sharma SK, Carter LM, Edwards KJ, Pourat J, Ragupathi A, Janjigian YY, Durack JC, Lewis JS. Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy. Nat Commun. 2018 Dec 3; 9(1):e5137. doi: 10.1038/s41467-018-07608-w. PMID: 30510281; PMCID: PMC6277446.

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