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Precision Radio-Theranostics Translational Laboratories (PRT2L)

Kooresh Isaac Shoghi

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:
4461 Clinical Sciences Research Building (CSRB)
(314) 362-8990
Email: shoghik@mir.wustl.edu
 

Current Position
Associate Professor of Radiology, Biomedical Engineering, Biochemistry, and Computational Systems Biology
Co-Director, Preclinical PET/CT Imaging Facility

Research Interests
The research interests of my lab are cross-disciplinary spanning the biology of disease mechanisms, engineering and imaging sciences & informatics. Current projects include:

  • Multi-tissue (e.g., heart, liver, muscle, adipose tissue) metabolic regulation of diabetes and its co-morbidities with emphasis on sex-differences in metabolic regulation
  • Quantitative imaging to predict and assess response to therapy in cancer
  • Development of quantitative imaging algorithms for preclinical and clinical imaging
  • Development of tissue micro-bioreactors to enable research, discovery, and validation of imaging and therapeutic biomarkers
     

Key Publications:

  1. Shoghi KI, Xu J, Su Y, He J, Rowland D, Yan Y, Garbow JR, Tu Z, Jones LA, Higashikubo R, Wheeler KT, Lubet RA, Mach RH, You M. Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [18F]ISO-1, PLoS One. 8(9):e74188, 2013.
  2. Whitehead TD, Nemanich ST, Dence C, and Shoghi KI. A PET-compatible tissue bioreactor for research, discovery, and validation of imaging biomarkers and radiopharmaceuticals: System design and proof-of-concept studies, J Nucl Med. 54(10):1812-9, 2013.
  3. Devanathan S, Nemanich ST, Kovacs A, Fettig N, Gropler RJ, and Shoghi KI, Genomic and metabolic disposition of non-obese type 2 diabetic rats to increased myocardial fatty acid metabolism, PLoS One. 8(10):e78477, 2013.
  4. Samuel Nemanich, Sudheer Rani, Kooresh Shoghi, In vivo multi-tissue efficacy of PPARγ therapy on glucose and fatty acid metabolism in obese type 2 diabetic rats, Obesity. 21(12):2522-2529, 2013.
  5. Sriram Devanathan, Timothy Whitehead, George G. Schweitzer, Nicole Fettig, Attila Kovacs, Kenneth S. Korach, Brian N. Finck, Kooresh I. Shoghi, An animal model with a cardiomyocyte-specific deletion of estrogen receptor alpha: Functional, metabolic, and differential network analysis, PLoS One. 9(7):e101900, 2014.