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Precision Radio-Theranostics Translational Laboratories (PRT2L)

Kooresh Isaac Shoghi

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:
4461 Clinical Sciences Research Building (CSRB)
(314) 362-8990
Email: shoghik@wustl.edu
 

Current Position
Professor of Radiology, Biomedical Engineering, Biochemistry, and Computational Systems Biology
Co-Director, Preclinical PET/CT Imaging Facility

Research Interests
The research interests of my lab are cross-disciplinary spanning the biology of disease mechanisms, engineering and imaging sciences & informatics. Current projects include:

  • Multi-tissue (e.g., heart, liver, muscle, adipose tissue) metabolic regulation of diabetes and its co-morbidities with emphasis on sex-differences in metabolic regulation
  • Quantitative imaging to predict and assess response to therapy in cancer
  • Development of quantitative imaging algorithms for preclinical and clinical imaging
  • Development of tissue micro-bioreactors to enable research, discovery, and validation of imaging and therapeutic biomarkers
     

Key Publications:

  1. Shoghi KI, Xu J, Su Y, He J, Rowland D, Yan Y, Garbow JR, Tu Z, Jones LA, Higashikubo R, Wheeler KT, Lubet RA, Mach RH, You M. Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1. PLoS One. 2013 Sep 20; 8(9):e74188. eCollection 2013. PMID: 24073202. PMCID: PMC3779213. doi: 10.1371/journal.pone.0074188.
  2. Whitehead TD, Nemanich ST, Dence C, Shoghi KI. A PET-compatible tissue bioreactor for research, discovery, and validation of imaging biomarkers and radiopharmaceuticals: system design and proof-of-concept studies. J Nucl Med. 2013 Oct;54(10):1812-1819. PMID: 23978447. PMCID: PMC3971724. doi: 10.2967/jnumed.113.119776.
  3. Nemanich S, Rani S, Shoghi K. In vivo multi-tissue efficacy of peroxisome proliferator-activated receptor-γ therapy on glucose and fatty acid metabolism in obese type 2 diabetic rats. Obesity (Silver Spring). 2013 Dec; 21(12):2522-2529. PMID: 23512563. PMCID: PMC3695080. doi: 10.1002/oby.20378.
  4. Devanathan S, Whitehead T, Schweitzer GG, Fettig N, Kovacs A, Korach KS, Finck BN, Shoghi KI. An animal model with a cardiomyocyte-specific deletion of estrogen receptor alpha: functional, metabolic, and differential network analysis. PLoS One. 2014 Jul 7;9(7):e101900. eCollection 2014. PMID: 25000186. PMCID: PMC4085004. doi: 10.1371/journal.pone.0101900.