Precision Radio-Theranostics Translational Laboratories (PRT2L)

Jinbin Xu

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

254C McDonnell Medical Sciences Building
(314) 747-0693

Current Position
Instructor in Radiology

Research Interests
Focuses on the development and characterization of probes for receptor and enzyme-based CNS and oncology imaging with functional imaging techniques including in vivo positron emission tomography (PET) and in vitro quantitative autoradiography (QAG).   Our current projects include:

  • Dopamine D3 receptor regulation in the central nervous system
  • Neuroinflammation
  • Metabolic activity in biological systems
  • Cancer stem cell differentiation and senescence

Key Publications:

  1. Gräff J, Joseph NF, Horn M, Meng J, Samiei A, Seo J, Rei D, Bero AW, Wagner F, Holson E, Xu J, Sun J, Mach RH, Haggarty SJ, Tsai LH. Epigenetic priming of memory reconsolidation to attenuate remote fear memories. Cell. 16;156(1-2):261-76, 2014.
  2. Sun J, Kouranova E, Cui X, Mach RH, Xu J. Regulation of dopamine pre-synaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats, Neurosci. Lett.  557 Pt B: 123-128, 2013.
  3. Sun, J., Cairns, N.J., Perlmutter, J.S., Mach, R.H., Xu, J*. Regulation of dopamine D3 receptor in the striatal regions and substantia nigra in diffuse Lewy body disease (DLBD). Neuroscience. 248C 112-126, 2013.
  4. Xu, J., Vangveravong, S., Li, S., Fan, J., Jones, L.A., Cui, J., Wang, R., Tu, Z., Perlmutter, J.S., Mach, R.H. Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiotracer [11C]SV-III-130. NeuroImage. 71:168-74, 2013.
  5. Xu, J., Zeng, C., Chu, W., Pan, F., Rothfuss, J.M., Zhang, F., Tu, Z., Zhou, D., Zeng, D., Vangveravong, S., Johnston, F., Spitzer, D., Chang, K.C., Hotchkiss, R.S., Hawkins, W.G., Wheeler, K.T., Mach, R.H. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor-binding site. Nat. Commun. 2: 380, 2011.