Precision Radio-Theranostics Translational Laboratories (PRT2L)

Jinbin Xu

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

1739B West Building
Office Phone: (314) 747-0693

Lab Shipping Address:
4523 Clayton Ave.-1738 West Building
Lab phone: 314-747-0632

Current Position
Assistant Professor of Radiology

Research Interests

Focuses on the development and characterization of probes for receptor and enzyme-based CNS and oncology imaging with functional imaging techniques including in vivo positron emission tomography (PET) and in vitro quantitative autoradiography (QAG).   Our current projects include:

  • Dopamine D3 receptor regulation in the central nervous system
  • Neuroinflammation
  • Metabolic activity in biological systems
  • Cancer stem cell differentiation and senescence

Key Publications:

  1. Yang P, Knight WC, Li H, Guo Y, Perlmutter JS, Benzinger TLS, Morris JC, Xu J. Dopamine D1 + D3 receptor density may correlate with Parkinson disease clinical features. Ann Clin Transl Neurol. 2021 Jan;8(1):224-237. Epub 2020 Dec 21. PMID: 33348472. PMCID: PMC7818081. doi: 10.1002/acn3.51274.
  2. Chen H, Afrin S, Guo Y, Chu W, Benzinger TLS, Rogers BE, Garbow JR, Perlmutter JS, Zhou D, Xu J. Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1. Int J Mol Sci. 2020 Nov 23; 21(22):e8860. PMID: 33238630. PMCID: PMC7700685. doi: 10.3390/ijms21228860.
  3. Li H, Yang P, Knight W, Guo Y, Perlmutter JS, Benzinger TLS, Morris JC, Xu J . The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases. J Neurochem. 2020 Jan; 152(2):235-251. Epub 2019 Nov 4. PMID: 31613384. PMCID: PMC6981021. doi: 10.1111/jnc.14898.
  4. Li H, Knight WC, Yang P, Guo Y, Perlmutter JS, Morris JC, Bateman RJ, Benzinger TLS, Xu J. Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype. Int J Mol Sci . 2020 Aug 22;21(17):6047. PMID: 32842621. PMCID: PMC7503242. doi: 10.3390/ijms21176047.
  5. Yang P, Perlmutter JS, Benzinger TLS, Morris JC, Xu J. Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment? Ageing Res Rev. 2020 Jan; 57:100994. Epub 2019 Nov 22. PMID: 31765822. PMCID: PMC6939386. doi: 10.1016/j.arr.2019.100994.