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Precision Radio-Theranostics Translational Laboratories (PRT2L)

Hanwen

Hanwen Zhang

Contact Information
Washington University School of Medicine
Department of Radiology
CB 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:
4424 A Clinical Sciences Research Building
314-273-3711
hanwen.zhang@wustl.edu

Current Position
Assistant Professor of Radiology
 

Research Interests


My research focuses on the design, synthesis and validation of radioisotope- or dual reporter- (radioisotope and fluorescent) conjugated ligands for in vivo targeted imaging of receptors, enzymes and transporters; and for radionuclide-based treatment in animal setting. After preclinical validation, the most promising agents are translated into clinical trials for further evaluation in patients. Research Areas include

Development of 18F, 64Cu, 89Zr, 223Ra or other radiometal-labeled small molecules and peptides;Development of radiolabeled monoclonal antibody and nanoparticle;
Preclinical evaluation of multimodalities for intraoperative imaging;Translational research of novel radioligand for cardiovascular and oncological disease;

 

Key Publications:

  1. Pandit-Taskar N, Zanzonico P, Staton KD, Carrasquillo JA, Reidy-Lagunes D, Lyashchenko S, Burnazi E, Zhang H, Lewis JS, Blasberg R, Larson SM, Weber WA, Modak S. Biodistribution and Dosimetry of 18F-Meta-Fluorobenzylguanidine: A First-in-Human PET/CT Imaging Study of Patients with Neuroendocrine Malignancies. J Nucl Med. 2018 Jan; 59(1):147-153. PMID: 28705916. PMCID: PMC5750519. DOI: 10.2967/jnumed.117.193169.
  2. Zhang H, Kanduluru AK, Desai P, Ahad A, Carlin S, Tandon N, Weber WA, Low PS. Synthesis and Evaluation of a Novel 64Cu- and 67Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts. Bioconjug Chem. 2018 Apr; 29(4):1319-1326. PMID: 29466853. DOI: 10.1021/acs.bioconjchem.8b00063.
  3. Zhang H, Desai P, Koike Y, Houghton J, Carlin S, Tandon N, Touijer K, Weber WA. Dual-Modality Imaging of Prostate Cancer with a Fluorescent and Radiogallium-Labeled Gastrin-Releasing Peptide Receptor Antagonist. J Nucl Med. 2017 Jan; 58(1):29-35. PMID: 27516447. PMCID: PMC5209642. DOI: 10.2967/jnumed.116.176099.
  4. Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, Holland EC, Mellinghoff IK, Kung HF, Lewis JS, Thompson CB. Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo. Sci Transl Med. 2015 Feb 11; 7(274):e274ra17. PMID: 25673762. PMCID: PMC4431550. DOI: 10.1126/scitranslmed.aaa1009.
  5. Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008; 117(3):379-87. PMID: 18158358. PMCID: PMC2663426. DOI: 10.1161/CIRCULATIONAHA.107.741181.