Precision Radio-Theranostics Translational Laboratories (PRT2L)


Hanwen Zhang

Contact Information
Washington University School of Medicine
Department of Radiology
CB 8225
510 S. Kingshighway
St. Louis, MO 63110

Room 4424 A
Clinical Sciences Research Building
Phone: 314-273-3711

Current Position
Assistant Professor of Radiology

Research Interests

My research focuses on the design, synthesis and validation of radioisotope- or dual reporter- (radioisotope and fluorescent) conjugated ligands for in vivo targeted imaging of receptors, enzymes and transporters; and for radionuclide-based treatment in animal setting. After preclinical validation, the most promising agents are translated into clinical trials for further evaluation in patients. Research Areas include

Development of 18F, 64Cu, 89Zr, 223Ra or other radiometal-labeled small molecules and peptides;Development of radiolabeled monoclonal antibody and nanoparticle;
Preclinical evaluation of multimodalities for intraoperative imaging;Translational research of novel radioligand for cardiovascular and oncological disease;


Key Publications:

1. Zhang H, Kanduluru AK, Desai P, Ahad A, Carlin S, Tandon N, Weber WA, Low PS. Synthesis and Evaluation of a Novel 64Cu- and 67Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts. Bioconjugate chemistry. 2018; 29(4):1319-1326. DOI: 10.1021/acs.bioconjchem.8b00063 PMID: 29466853
2. Pandit-Taskar N, Zanzonico P, Staton KD, Carrasquillo JA, Reidy-Lagunes D, Lyashchenko S, Burnazi E, Zhang H, Lewis JS, Blasberg R, Larson SM, Weber WA, Modak S. Biodistribution and Dosimetry of 18F-Meta-Fluorobenzylguanidine: A First-in-Human PET/CT Imaging Study of Patients with Neuroendocrine Malignancies. Journal of nuclear medicine. 2018; 59(1):147-153. PMID: 28705916 PMCID: PMC5750519 DOI: 10.2967/jnumed.117.193169
3. Zhang H, Desai P, Koike Y, Houghton J, Carlin S, Tandon N, Touijer K, Weber WA. Dual-Modality Imaging of Prostate Cancer with a Fluorescent and Radiogallium-Labeled Gastrin-Releasing Peptide Receptor Antagonist. Journal of nuclear medicine. 2017; 58(1):29-35. PMID: 27516447 PMCID: PMC5209642. DOI: 10.2967/jnumed.116.176099
4. Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, Holland EC, Mellinghoff IK, Kung HF, Lewis JS, Thompson CB. Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo. Science translational medicine. 2015; 7(274):274ra17. PMID: 25673762 PMCID: PMC4431550. DOI: 10.1126/scitranslmed.aaa1009
5. Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008; 117(3):379-87. PMID: 18158358 PMCID: PMC2663426. DOI: 10.1161/CIRCULATIONAHA.107.741181