Precision Radio-Theranostics Translational Laboratories (PRT2L)

Ganesh Chand

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

3114D East Building 

Current Position
Instructor in Radiology

Research Interests
Our research emphasis is on uncovering the biomarkers of mental diseases and disorders, such as schizophrenia and mild cognitive impairment/Alzheimer's disease. We focus on the state-of-the-art multi-modal neuroimaging, neurophysiological, neuropharmacological, and machine learning/artificial intelligence methodologies and aim to aid on disease diagnosis, prognosis, and precision medicine.

Research Areas:

  • Investigation of multi-modal neuroimaging, neurophysiological, and neuropharmacological biomarkers  in health and disease
  • Development of brain image and signal analysis algorithms and frameworks
  • Development of machine learning/artificial intelligence models and methods
  • Clinical applications of quantitative methods
Key Publications:

  1. Chand GB, Dwyer DB, Erus G, Sotiras A, Varol E, Srinivasan D, Doshi J, Pomponio R, Pigoni A, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, Meisenzahl E, Busatto GF, Crespo-Facorro B, Pantelis C, Wood SJ, Zhuo C, Shinohara RT, Shou H, Fan Y, Gur RC, Gur RE, Satterthwaite TD, Koutsouleris N, Wolf DH, Davatzikos C. Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning. Brain. 2020 Mar; 143(3):1027-1038. PMID: 32103250. PMCID: PMC7089665. doi: 10.1093/brain/awaa025
  2. Chand GB, Habes M, Dolui S, Detre JA, Wolk DA, Davatzikos C. Estimating regional cerebral blood flow using resting-state functional MRI via machine learning. J Neurosci Methods. 2020 Feb 1; 331:e108528. Epub 2019 Nov 19. PMID: 31756399. PMCID: PMC7216635. doi: 10.1016/j.jneumeth.2019.108528.
  3. Chand GB, Hajjar I, Qiu D. Disrupted interactions among the hippocampal, dorsal attention, and central-executive networks in amnestic mild cognitive impairment. Hum Brain Mapp. 2018 Dec;39(12):4987-4997. PMID: 30272830. PMCID: PMC6866643. doi: 10.1002/hbm.24339.
  4. Chand GB, Wu J, Hajjar I, Qiu D. Interactions of the Salience Network and Its Subsystems with the Default-Mode and the Central-Executive Networks in Normal Aging and Mild Cognitive Impairment. Brain Connect . 2017 Sep;7(7):401-412. doi: 10.1089/brain.2017.0509. PMID: 28707959. PMCID: PMC5647507.
  5. Chand GB, Dhamala M. The salience network dynamics in perceptual decision-making. Neuroimage. 2016 Jul 1;134:85-93. Epub 2016 Apr 11. PMID: 27079535. doi: 10.1016/j.neuroimage.2016.04.018.