Precision Radio-Theranostics Translational Laboratories (PRT2L)

Dong Zhou

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

4424E Clinical Sciences Research Building
(314) 362-9072

Current Position
Assistant Professor of Radiology

Research Interests
My research focuses on fluorine-18 radiochemistry and development of novel PET tracers for preclinical and clinical applications.

  • New method development for fluorine-18 labeling
  • Novel PET tracer development for imaging of targets with clinical relevance
  • Translation and optimization of labeling methods for automated production

Key Publications:

  1. D. Zhou, W. Chu, J. Rothfuss, C. Zeng, J. Xu, L. Jones, M. J. Welch, R. H. Mach. Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Bioorgan. Med. Chem. Lett. 16(19): 5041, 2006.
  2. D. Zhou, H. Lee, J. M. Rothfuss, D. L. Chen, D. E. Ponde, M. J. Welch, R. H. Mach. Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase. J. Med. Chem. 52(8): 2443, 2009.
  3. A. M. Fowler, S. R. Chan, T. L. Sharp, N. M. Fettig, D. Zhou, C. S. Dence, K. E. Carlson, M. Jeyakumar, J. A. Katzenellenbogen, R. D. Schreiber, M. J. Welch. Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer. J. Nucl. Med. 53(7): 1119, 2012.
  4. D. Zhou, W. Chu, J. Xu, L. A. Jones,X. Peng, S. Li, D. L. Chen, R. H. Mach. Synthesis, [18F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography, Bioorg. Med. Chem. 22(5): 1700, 2014.
  5. W. Chu, A. Chepetan, D. Zhou, K. I. Shoghi, J. Xu, L. L. Dugan, R. J. Gropler, M. A. Mintun, R. H. Mach. Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo. Org. Biomol. Chem. 12(25): 4421, 2014.

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