Go

Precision Radio-Theranostics Translational Laboratories (PRT2L)

Dong Zhou

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

Office:
4424E Clinical Sciences Research Building
(314) 362-9072
zhoud@mir.wustl.edu

Current Position
Assistant Professor of Radiology
 

Research Interests
My research focuses on radiochemistry and development of novel radioligands for PET imaging and targeted radiotherapy in pre-clinical and clinical applications.

  • Novel method development for fluorine-18 labeling of small molecules and biomolecules
  • Novel PET tracer development for imaging of targets with clinical relevance
  • Targeted radiotherapy with therapeutic isotope labeled PARP-1 ligands
  • Translation and optimization of automated production of radiopharmaceuticals
     

Key Publications:

  1. Zhou D, Chu W, Xu J, Jones LA, Peng X, Li S, Chen DL, Mach RH. Synthesis, [ 18F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem. 2014 May; 22(5):1700-7. PMID: 24503274. PMCID: PMC4020173. doi: 10.1016/j.bmc.2014.01.019.
  2. Michel LS, Dyroff S, Brooks FJ, Spayd KJ, Lim S, Engle JT, Phillips S, Tan B, Wang-Gillam A, Bognar C, Chu W, Zhou D, Mach RH, Laforest R, Chen DL. PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. Radiology. 2017 Feb; 282(2):453-463. Epub 2016 Nov 14. PMID: 27841728. PMCID: PMC5283874. doi: 10.1148/radiol.2016161929. Erratum in: Radiology. 2019 Apr;291(1):271 .
  3. Zhou D, Chu W, Voller T, Katzenellenbogen JA. Copper-mediated nucleophilic radiobromination of aryl boron precursors: Convenient preparation of a radiobrominated PARP-1 inhibitor. Tetrahedron Lett. 2018 May; 59(20), 1963-1967. PMID: 30349147. PMCID: PMC6195330. doi: 10.1016/j.tetlet.2018.04.024 .
  4. Zhou D, Xu J, Mpoy C, Chu W, Kim SH, Li H, Rogers BE, Katzenellenbogen JA. Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer. Nucl Med Biol. 2018 Nov; 66: 26-31. Epub 2018 Aug 24. PMID: 30195072. PMCID: PMC6252111. doi: 10.1016/j.nucmedbio.2018.08.003 .