Precision Radio-Theranostics Translational Laboratories (PRT2L)

Dong Zhou

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
510 S. Kingshighway
St. Louis, MO 63110

4424E Clinical Sciences Research Building
(314) 362-9072

Current Position
Assistant Professor of Radiology

Research Interests
My research focuses on radiochemistry and development of novel radioligands for PET imaging and targeted radiotherapy in pre-clinical and clinical applications.

  • Novel method development for fluorine-18 labeling of small molecules and biomolecules
  • Novel PET tracer development for imaging of targets with clinical relevance
  • Targeted radiotherapy with therapeutic isotope labeled PARP-1 ligands
  • Translation and optimization of automated production of radiopharmaceuticals

Key Publications:

  1. Zhou D, Chu W, Xu J, Jones LA, Peng X, Li S, Chen DL, Mach RH. Synthesis, [ 18F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem. 2014 May; 22(5):1700-7. PMID: 24503274. PMCID: PMC4020173. doi: 10.1016/j.bmc.2014.01.019.
  2. Michel LS, Dyroff S, Brooks FJ, Spayd KJ, Lim S, Engle JT, Phillips S, Tan B, Wang-Gillam A, Bognar C, Chu W, Zhou D, Mach RH, Laforest R, Chen DL. PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. Radiology. 2017 Feb; 282(2):453-463. Epub 2016 Nov 14. PMID: 27841728. PMCID: PMC5283874. doi: 10.1148/radiol.2016161929. Erratum in: Radiology. 2019 Apr;291(1):271 .
  3. Zhou D, Chu W, Voller T, Katzenellenbogen JA. Copper-mediated nucleophilic radiobromination of aryl boron precursors: Convenient preparation of a radiobrominated PARP-1 inhibitor. Tetrahedron Lett. 2018 May; 59(20), 1963-1967. PMID: 30349147. PMCID: PMC6195330. doi: 10.1016/j.tetlet.2018.04.024 .
  4. Zhou D, Xu J, Mpoy C, Chu W, Kim SH, Li H, Rogers BE, Katzenellenbogen JA. Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer. Nucl Med Biol. 2018 Nov; 66: 26-31. Epub 2018 Aug 24. PMID: 30195072. PMCID: PMC6252111. doi: 10.1016/j.nucmedbio.2018.08.003 .