Washington University School of Medicine
Department of Radiology
510 S. Kingshighway
St. Louis, MO 63110
Radiological Chemistry Imaging Laboratory & Cyclotron Facilities
Room 4424A, Clinical Sciences Research Building
Assistant Professor of Radiology
Diane Abou is an assistant professor at the Mallinckrodt Institute of Radiology. She is a member of Precision Radio-Theranostics Translational Laboratories (PRT2L) and the Cyclotron facility.
Her research focuses in better understanding the fundamental properties of alpha radionuclide therapy, currently used for treatment of cancers with bone metastases. One of her mission is to develop and/or improve radionuclide therapy and reduce off-target toxicities.
To conduct this preclinical research, she has created an in-house supply of Radium-223 dichloride, building a 223Ra/227Th microgenerator initiated from traces sources of Actinium-227. This finding allows for an on-demand supply of alpha emitters tailored to in-laboratory research needs.
As a member of the Cyclotron facility, Mallinckrodt Institute of Radiology, she contributes to the production and quality control evaluation of radionuclides for alpha emitting therapy including Actinium-225 radiopharmaceuticals, Thorium-227 radiopharmaceuticals and in-house production of Radium-223 and Thorium-227 isotopes for preclinical radiopharmaceutical labeling.
- Abou DS, Fears A, Summer L, Longtine M, Benabdallah N, Riddle RC, Ulmert D, Michalski J, Wahl RL, Chesner D, Doucet M, Zachos N, Simons B, Thorek DL. Improved Radium-223 Therapy with Combination Epithelial Sodium Channel Blockade. J Nucl Med. 2021 Apr 9:jnumed.121.261977. Epub ahead of print. PMID: 33837069. doi: 10.2967/jnumed.121.261977.
- Abou DS, Thiele NA, Gutsche NT, Villmer A, Zhang H, Woods JJ, Baidoo KE, Escorcia FE, Wilson JJ, Thorek DLJ. Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand. Chem. Sci. 2021; 12:e3733. doi: 10.1039/D0SC06867E.
- Abou DS, Rittenbach A, Tomlinson RE, Finley PA, Tsui B, Simons BW, Jha AK, Ulmert D, Riddle RC, Thorek DLJ. Preclinical Single Photon Emission Computed Tomography of Alpha Particle-Emitting Radium-223. Cancer Biother Radiopharm. 2020 Sep; 35(7):520-529. PMID: 32182119. PMCID: PMC7475100. doi: 10.1089/cbr.2019.3308.
- Abou DS, Pickett J, Mattson JE, Thorek DLJ. A Radium-223 microgenerator from cyclotron-produced trace Actinium-227. Appl Radiat Isot. 2017 Jan;119:36-42. Epub 2016 Nov 4. PMID: 27835737. PMCID: PMC5136344. doi: 10.1016/j.apradiso.2016.10.015.