Precision Radio-Theranostics Translational Laboratories (PRT2L)




Daniel L.J. Thorek

Contact Information
Washington University School of Medicine
Department of Radiology
CB 8225
510 S. Kingshighway
St. Louis, MO 63110

Room 4424D
Clinical Sciences Research Building
St. Louis, MO 63110
Phone: 314-747-5624

Current Position
Associate Professor of Radiology, Biomedical Engineering

Research Interests

Our research is focused at the intersection of quantitative imaging and targeted therapeutics. Utilizing advanced model systems of disease with noninvasive measures of treatment response, we seek to develop and optimize treatments to inform patient management and to improve outcomes.

Targeted radionuclide therapy – we investigate methods to produce and specifically target disease sites with therapeutic radionuclide payloads. Novel diagnostic imaging agents to detect, characterize and monitor disease. Understanding of how radionuclide therapy can be improved through sensitization of target cells and mitigation of normal tissue damage.

Research Lab Website

Key Publications:

  1. Abou DS, Thiele NA, Gutsche NT, Villmer A, Zhang H, Woods JJ, Baidoo KE, Escorcia FE, Wilson JJ, Thorek DLJ. Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand Chem Sci. 2021 Jan; 12:3733-3742. doi: 10.1039/D0SC06867E.
  2. Simons BW, Turtle NF, Ulmert DH, Abou DS, Thorek DLJ. PSMA expression in the Hi-Myc model; extended utility of a representative model of prostate adenocarcinoma for biological insight and as a drug discovery tool. Prostate. 2019 May;79(6):678-685. doi: 10.1002/pros.23770. Epub 2019 Jan 17. PMID: 30656716; PMCID: PMC6519119.
  3. McDevitt MR, Thorek DLJ, Hashimoto T, Gondo T, Veach DR, Sharma SK, Kalidindi TM, Abou DS, Watson PA, Beattie BJ, Timmermand OV, Strand SE, Lewis JS, Scardino PT, Scher HI, Lilja H, Larson SM, Ulmert D. Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer. Nat Commun. 2018 Apr 24;9(1):1629. doi: 10.1038/s41467-018-04107-w. PMID: 29691406; PMCID: PMC5915579.
  4. Marciscano AE, Thorek DLJ. Role of noninvasive molecular imaging in determining response. Adv Radiat Oncol. 2018 Oct-Dec; 3(4):534-547. doi: 10.1016/j.adro.2018.07.006. eCollection 2018 Oct-Dec. Review. PMID: 30370353; PMCID: PMC6200886.
  5. Abou DS, Ulmert D, Doucet M, Hobbs RF, Riddle RC, Thorek DL. Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis. J Natl Cancer Inst. 2016 May;108(5). doi: 10.1093/jnci/djv380. Print 2016 May. PMID: 26683407; PMCID: PMC4849807.
  6. Thorek DL, Watson PA, Lee SG, Ku AT, Bournazos S, Braun K, Kim K, Sjöström K, Doran MG, Lamminmäki U, Santos E, Veach D, Turkekul M, Casey E, Lewis JS, Abou DS, van Voss MR, Scardino PT, Strand SE, Alpaugh ML, Scher HI, Lilja H, Larson SM, Ulmert D. Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis. Sci Transl Med. 2016 Nov 30; 8(367):367ra167. doi: 10.1126/scitranslmed.aaf2335. PMID: 27903863; PMCID: PMC5568040.