Precision Radio-Theranostics Translational Laboratories (PRT2L)

Jha_Abhinav jpg crop

Abhinav K. Jha

Contact Information
Washington University School of Medicine
Department of Radiology
CB 8225
510 S. Kingshighway
St. Louis, MO 63110

Room 4424F Clinical Sciences Research Building
(314) 273-2655 (Medical Campus)

Room 2002 Brauer Hall
(314) 935-5897 (Danforth Campus:)

Current Position
Assistant Professor of Radiology and Biomedical Engineering

Research Interests
My research is in the design of medical imaging systems and algorithms for optimized performance in clinical tasks using quantitative measures of task performance. A major area of focus is on improving clinical quantitative imaging, with applications such as in improving the reliability of imaging biomarkers for monitoring cancer-treatment response and in improving dosimetry for therapy. Reducing radiation dose for imaging is another area of focus. Research areas:

Research Lab Website

  • Objective assessment of image quality
  • Image analysis and reconstruction
  • Machine learning for radiology
  • Clinical translation of computational imaging methods

Key Publications:

  1. Rahman A, Zhu Y, Clarkson E, Kupinski MA, Frey EC, Jha AK. Fisher information analysis of list-mode SPECT emission data for joint estimation of activity and attenuation distribution. Inverse Probl. 2020 Aug; 36(8):084002. doi: 10.1088/1361-6420/ab958b.PMID: 33071423. PMCID: PMC7561050.
  2. Leung KH, Marashdeh W, Wray R, Ashrafinia S, Pomper MG, Rahmim A, Jha AK . A physics-guided modular deep-learning based automated framework for tumor segmentation in PET. Phys Med Biol. 2020 Dec; 65(24):245032. doi: 10.1088/1361-6560/ab8535. PMID: 32235059.
  3. Jha AK, Caffo B, Frey EC. A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods. Phys Med Biol. 2016 Apr; 61(7):2780-800. doi: 10.1088/0031-9155/61/7/2780. PMID: 26982626. PMCID: PMC4921224.
  4. Jha AK, Mena E, Caffo B, Ashrafinia S, Rahmim A, Frey E, Subramaniam RM. Practical no-gold-standard evaluation framework for quantitative imaging methods: application to lesion segmentation in positron emission tomography. J Med Imaging (Bellingham) . 2017 Jan; 4(1):011011. doi: 10.1117/1.JMI.4.1.011011. PMID: 28331883. PMCID: PMC5335899.
  5. Jha AK, Barrett HH, Frey EC, Clarkson E, Caucci L, Kupinski MA. Singular value decomposition for photon-processing nuclear imaging systems and applications for reconstruction and computing null functions. Phys Med Biol. 2015 Sep; 60(18):7359-85. doi: 10.1088/0031-9155/60/18/7359. PMID: 26350439; PMCID: PMC4711280.