Optical Radiology Laboratory (ORL)

Selected Publications (for full list of publications access) PubMED

1. Zheleznyak A, Shokeen M, Achilefu S. Nanotherapeutics for multiple myeloma. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018:e1526. doi: 10.1002/wnan.1526. PubMed PMID: 29701006.

2. Kotagiri N, Cooper ML, Rettig M, Egbulefu C, Prior J, Cui G, Karmakar P, Zhou M, Yang X, Sudlow G, Marsala L, Chanswangphuwana C, Lu L, Habimana-Griffin L, Shokeen M, Xu X, Weilbaecher K, Tomasson M, Lanza G, DiPersio JF, Achilefu S. Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer. Nat Commun. 2018;9(1):275. doi: 10.1038/s41467-017-02758-9. PubMed PMID: 29348537; PMCID: PMC5773683.

3. Tang R, Habimana-Griffin LM, Lane DD, Egbulefu C, Achilefu S. Nanophotosensitive drugs for light-based cancer therapy: what does the future hold? Nanomedicine (Lond). 2017;12(10):1101-5. doi: 10.2217/nnm-2017-0077. PubMed PMID: 28447872; PMCID: PMC5480785.

4. Mondal SB, Gao S, Zhu N, Habimana-Griffin L, Akers WJ, Liang R, Gruev V, Margenthaler J, Achilefu S. Optical See-Through Cancer Vision Goggles Enable Direct Patient Visualization and Real-Time Fluorescence-Guided Oncologic Surgery. Ann Surg Oncol. 2017;24(7):1897-903. doi: 10.1245/s10434-017-5804-8. PubMed PMID: 28213790; PMCID: PMC5503161.

5. Gilson RC, Black KCL, Lane DD, Achilefu S. Hybrid TiO2 -Ruthenium Nano-photosensitizer Synergistically Produces Reactive Oxygen Species in both Hypoxic and Normoxic Conditions. Angew Chem Int Ed Engl. 2017;56(36):10717-20. doi: 10.1002/anie.201704458. PubMed PMID: 28667692; PMCID: PMC5749187.

6. Som A, Raliya R, Tian L, Akers W, Ippolito JE, Singamaneni S, Biswas P, Achilefu S. Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo. Nanoscale. 2016;8(25):12639-47. doi: 10.1039/c5nr06162h. PubMed PMID: 26745389; PMCID: PMC4919221.

7. Tang R, Xue J, Xu B, Shen D, Sudlow GP, Achilefu S. Tunable ultrasmall visible-to-extended near-infrared emitting silver sulfide quantum dots for integrin-targeted cancer imaging. ACS Nano. 2015;9(1):220-30. doi: 10.1021/nn5071183. PubMed PMID: 25560768; PMCID: PMC4310643.

8. Kotagiri N, Sudlow GP, Akers WJ, Achilefu S. Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers. Nat Nanotechnol. 2015;10(4):370-9. doi: 10.1038/nnano.2015.17. PubMed PMID: 25751304; PMCID: PMC4393353.

9. Black KC, Akers WJ, Sudlow G, Xu B, Laforest R, Achilefu S. Dual-radiolabeled nanoparticle SPECT probes for bioimaging. Nanoscale. 2015;7(2):440-4. doi: 10.1039/c4nr05269b. PubMed PMID: 25418982; PMCID: PMC4268305.

10. Shen D, Bai M, Tang R, Xu B, Ju X, Pestell RG, Achilefu S. Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity. Sci Rep. 2013;3:1697. doi: 10.1038/srep01697. PubMed PMID: 23603888; PMCID: PMC3631771.

11. Tang R, Lee H, Achilefu S. Induction of pH sensitivity on the fluorescence lifetime of quantum dots by NIR fluorescent dyes. J Am Chem Soc. 2012;134(10):4545-8. doi: 10.1021/ja300276s. PubMed PMID: 22360301; PMCID: PMC3303939.

12. Berezin MY, Achilefu S. Fluorescence lifetime measurements and biological imaging. Chem Rev. 2010;110(5):2641-84. doi: 10.1021/cr900343z. PubMed PMID: 20356094; PMCID: PMC2924670.

13. Achilefu S, Bloch S, Markiewicz MA, Zhong T, Ye Y, Dorshow RB, Chance B, Liang K. Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression. Proc Natl Acad Sci U S A. 2005;102(22):7976-81. doi: 10.1073/pnas.0503500102. PubMed PMID: 15911748; PMCID: PMC1142399.

14. Ye Y, Bloch S, Achilefu S. Polyvalent carbocyanine molecular beacons for molecular recognitions. J Am Chem Soc. 2004;126(25):7740-1. doi: 10.1021/ja049441z. PubMed PMID: 15212497.