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Optical Radiology Laboratory (ORL)

Achilefu Publications
(1-208)

1. Tsen SW, Kingsley DH, Poweleit C, Achilefu S, Soroka DS, Wu T, et al. Studies of inactivation mechanism of non-enveloped icosahedral virus by a visible ultrashort pulsed laser. Virology journal. 2014;11(1):20. Epub 2014/02/06. doi: 10.1186/1743-422X-11-20. PubMed PMID: 24495489.
2. Hu D, Sarder P, Ronhovde P, Orthaus S, Achilefu S, Nussinov Z. Automatic segmentation of fluorescence lifetime microscopy images of cells using multiresolution community detection--a first study. Journal of microscopy. 2014;253(1):54-64. Epub 2013/11/21. doi: 10.1111/jmi.12097. PubMed PMID: 24251410; PubMed Central PMCID: PMC3893052.
3. Gandra N, Portz C, Tian L, Tang R, Xu B, Achilefu S, et al. Probing distance-dependent plasmon-enhanced near-infrared fluorescence using polyelectrolyte multilayers as dielectric spacers. Angew Chem Int Ed Engl. 2014;53(3):866-70. Epub 2014/01/01. doi: 10.1002/anie.201308516. PubMed PMID: 24376101.
4. Zhou M, Zhang X, Bai M, Shen D, Xu B, Kao J, et al. Click Reaction-Mediated Functionalization of Near-Infrared Pyrrolopyrrole Cyanine Dyes for Biological Imaging Applications. RSC advances. 2013;3(19):6756-8. Epub 2013/05/15. doi: 10.1039/C3RA40441B. PubMed PMID: 23671791; PubMed Central PMCID: PMC3650893.
5. Xue J, Shan L, Chen H, Li Y, Zhu H, Deng D, et al. Visual detection of STAT5B gene expression in living cell using the hairpin DNA modified gold nanoparticle beacon. Biosensors & bioelectronics. 2013;41:71-7. Epub 2012/11/06. doi: 10.1016/j.bios.2012.06.062. PubMed PMID: 23122230.
6. Xu X, Sarder P, Kotagiri N, Achilefu S, Nehorai A. Performance analysis and design of position-encoded microsphere arrays using the Ziv-Zakai bound. IEEE transactions on nanobioscience. 2013;12(1):29-40. Epub 2012/12/27. doi: 10.1109/TNB.2012.2230116. PubMed PMID: 23268386.
7. Wang Z, Zhang K, Shen Y, Smith J, Bloch S, Achilefu S, et al. Imaging mRNA expression levels in living cells with PNA.DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles. Organic & biomolecular chemistry. 2013;11(19):3159-67. Epub 2013/03/30. doi: 10.1039/c3ob26923j. PubMed PMID: 23538604; PubMed Central PMCID: PMC3687806.
8. Wang ST, Zhegalova NG, Gustafson TP, Zhou A, Sher J, Achilefu S, et al. Sensitivity of activatable reactive oxygen species probes by fluorescence spectroelectrochemistry. The Analyst. 2013;138(15):4363-9. Epub 2013/06/06. doi: 10.1039/c3an00459g. PubMed PMID: 23736882; PubMed Central PMCID: PMC3722072.
9. Wang J, Wheeler D, Zhang JZ, Achilefu S, Kang KA. NIR fluorophore-hollow gold nanosphere complex for cancer enzyme-triggered detection and hyperthermia. Advances in experimental medicine and biology. 2013;765:323-8. Epub 2012/08/11. doi: 10.1007/978-1-4614-4989-8_45. PubMed PMID: 22879051.
10. Solomon M, Nothdruft RE, Akers W, Edwards WB, Liang K, Xu B, et al. Multimodal fluorescence-mediated tomography and SPECT/CT for small-animal imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013;54(4):639-46. Epub 2013/03/01. doi: 10.2967/jnumed.112.105742. PubMed PMID: 23447655.
11. Shen D, Bai M, Tang R, Xu B, Ju X, Pestell RG, et al. Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity. Scientific reports. 2013;3:1697. Epub 2013/04/23. doi: 10.1038/srep01697. PubMed PMID: 23603888; PubMed Central PMCID: PMC3631771.
12. Sarder P, Yazdanfar S, Akers WJ, Tang R, Sudlow GP, Egbulefu C, et al. All-near-infrared multiphoton microscopy interrogates intact tissues at deeper imaging depths than conventional single- and two-photon near-infrared excitation microscopes. Journal of biomedical optics. 2013;18(10):106012. Epub 2013/10/24. doi: 10.1117/1.JBO.18.10.106012. PubMed PMID: 24150231; PubMed Central PMCID: PMC3805921.
13. Sarder P, Gullicksrud K, Mondal S, Sudlow GP, Achilefu S, Akers WJ. Dynamic optical projection of acquired luminescence for aiding oncologic surgery. Journal of biomedical optics. 2013;18(12):120501. Epub 2013/11/29. doi: 10.1117/1.JBO.18.12.120501. PubMed PMID: 24284472.
14. Pu Y, Xue J, Wang W, Xu B, Gu Y, Tang R, et al. Native fluorescence spectroscopy reveals spectral differences among prostate cancer cell lines with different risk levels. Journal of biomedical optics. 2013;18(8):87002. Epub 2013/08/06. doi: 10.1117/1.JBO.18.8.087002. PubMed PMID: 23912761; PubMed Central PMCID: PMC3763931.
15. Ntziachristos V, Achilefu S, Wang YP, Lin M. Special section on fluorescence molecular imaging honoring Prof. Roger Tsien, a pioneer in biomedical optics. Journal of biomedical optics. 2013;18(10):101301. Epub 2013/10/31. doi: 10.1117/1.JBO.18.10.101301. PubMed PMID: 24169645.
16. Ntziachristos V, Achilefu S, Wang YP, Lin M. Special section guest editorial: special section on fluorescence molecular imaging honoring prof. Roger tsien, a pioneer in biomedical optics. Journal of biomedical optics. 2013;18(10):101301. Epub 2013/10/31. doi: 10.1117/1.JBO.18.10.101301. PubMed PMID: 24169645.
17. Liu Y, Zhao YM, Akers W, Tang ZY, Fan J, Sun HC, et al. First in-human intraoperative imaging of HCC using the fluorescence goggle system and transarterial delivery of near-infrared fluorescent imaging agent: a pilot study. Translational research : the journal of laboratory and clinical medicine. 2013. Epub 2013/06/12. doi: 10.1016/j.trsl.2013.05.002. PubMed PMID: 23747795.
18. Liu Y, Solomon M, Achilefu S. Perspectives and potential applications of nanomedicine in breast and prostate cancer. Medicinal research reviews. 2013;33(1):3-32. Epub 2012/12/15. doi: 10.1002/med.20233. PubMed PMID: 23239045.
19. Liu Y, Njuguna R, Matthews T, Akers WJ, Sudlow GP, Mondal S, et al. Near-infrared fluorescence goggle system with complementary metal-oxide-semiconductor imaging sensor and see-through display. Journal of biomedical optics. 2013;18(10):101303. Epub 2013/06/04. doi: 10.1117/1.JBO.18.10.101303. PubMed PMID: 23728180; PubMed Central PMCID: PMC3667841.
20. Liu Y, Akers WJ, Bauer AQ, Mondal S, Gullicksrud K, Sudlow GP, et al. Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging. The Analyst. 2013;138(8):2254-7. Epub 2013/03/08. doi: 10.1039/c3an00165b. PubMed PMID: 23467534; PubMed Central PMCID: PMC3650133.
21. Lee H, Berezin MY, Tang R, Zhegalova N, Achilefu S. Pyrazole-substituted near-infrared cyanine dyes exhibit pH-dependent fluorescence lifetime properties. Photochemistry and photobiology. 2013;89(2):326-31. Epub 2012/10/26. doi: 10.1111/php.12009. PubMed PMID: 23094959; PubMed Central PMCID: PMC3578979.
22. Kotagiri N, Niedzwiedzki DM, Ohara K, Achilefu S. Activatable probes based on distance-dependent luminescence associated with Cerenkov radiation. Angew Chem Int Ed Engl. 2013;52(30):7756-60. Epub 2013/06/15. doi: 10.1002/anie.201302564. PubMed PMID: 23765506.
23. Gustafson TP, Dergunov SA, Akers WJ, Cao Q, Magalotti S, Achilefu S, et al. Blood Triggered Rapid Release Porous Nanocapsules. RSC advances. 2013;3(16):5547-55. Epub 2013/04/23. doi: 10.1039/C3RA22693J. PubMed PMID: 23606942; PubMed Central PMCID: PMC3627417.
24. Du C, Deng D, Shan L, Wan S, Cao J, Tian J, et al. A pH-sensitive doxorubicin prodrug based on folate-conjugated BSA for tumor-targeted drug delivery. Biomaterials. 2013;34(12):3087-97. Epub 2013/02/05. doi: 10.1016/j.biomaterials.2013.01.041. PubMed PMID: 23374705.
25. Dreger T, Watson JT, Akers W, Molligan J, Achilefu S, Schon LC, et al. Intravenous Application of CD271-selected Mesenchymal Stem Cells during Fracture Healing. Journal of orthopaedic trauma. 2013. Epub 2014/01/01. doi: 10.1097/BOT.0000000000000063. PubMed PMID: 24378433.
26. Deng D, Zhang D, Li Y, Achilefu S, Gu Y. Gold nanoparticles based molecular beacons for in vitro and in vivo detection of the matriptase expression on tumor. Biosensors & bioelectronics. 2013;49:216-21. Epub 2013/06/19. doi: 10.1016/j.bios.2013.05.018. PubMed PMID: 23770391.
27. Deng D, Qu L, Achilefu S, Gu Y. Broad spectrum photoluminescent quaternary quantum dots for cell and animal imaging. Chem Commun (Camb). 2013. Epub 2013/09/10. doi: 10.1039/c3cc45751f. PubMed PMID: 24013163.
28. Deng D, Cao J, Qu L, Achilefu S, Gu Y. Highly luminescent water-soluble quaternary Zn-Ag-In-S quantum dots for tumor cell-targeted imaging. Physical chemistry chemical physics : PCCP. 2013;15(14):5078-83. Epub 2013/03/02. doi: 10.1039/c3cp00046j. PubMed PMID: 23450151.
29. Cui S, Yin D, Chen Y, Di Y, Chen H, Ma Y, et al. In vivo targeted deep-tissue photodynamic therapy based on near-infrared light triggered upconversion nanoconstruct. ACS nano. 2013;7(1):676-88. Epub 2012/12/21. doi: 10.1021/nn304872n. PubMed PMID: 23252747.
30. Chen H, Zhang X, Dai S, Ma Y, Cui S, Achilefu S, et al. Multifunctional Gold Nanostar Conjugates for Tumor Imaging and Combined Photothermal and Chemo-therapy. Theranostics. 2013;3(9):633-49. Epub 2013/09/11. doi: 10.7150/thno.6630. PubMed PMID: 24019851; PubMed Central PMCID: PMC3767113.
31. Zhang X, Bloch S, Akers W, Achilefu S. Near-infrared molecular probes for in vivo imaging. Current protocols in cytometry / editorial board, J Paul Robinson, managing editor  [et al]. 2012;Chapter 12:Unit12 27. Epub 2012/04/04. doi: 10.1002/0471142956.cy1227s60. PubMed PMID: 22470154; PubMed Central PMCID: PMC3334312.
32. Ye Y, Akers W, Xu B, Bloch S, Odonkor C, Achilefu S. Near-infrared fluorescent divalent RGD ligand for integrin alphavbeta(3)-targeted optical imaging. Bioorganic & medicinal chemistry letters. 2012;22(17):5405-9. Epub 2012/08/09. doi: 10.1016/j.bmcl.2012.07.044. PubMed PMID: 22871580; PubMed Central PMCID: PMC3423536.
33. Xue B, Deng DW, Cao J, Liu F, Li X, Akers W, et al. Synthesis of NAC capped near infrared-emitting CdTeS alloyed quantum dots and application for in vivo early tumor imaging. Dalton Trans. 2012;41(16):4935-47. Epub 2012/03/28. doi: 10.1039/c2dt12436j. PubMed PMID: 22451225.
34. Xu X, Sarder P, Kotagiri N, Achilefu S, Nehorai A. Performance Analysis and Design of Position-Encoded Microsphere Arrays Using the Ziv-Zakai Bound. IEEE transactions on nanobioscience. 2012. Epub 2012/12/27. doi: 10.1109/TNB.2012.2230116. PubMed PMID: 23268386.
35. Xu M, Rettig MP, Sudlow G, Wang B, Akers WJ, Cao D, et al. Preclinical evaluation of Mab CC188 for ovarian cancer imaging. International Journal of Cancer. 2012;131(6):1351-9. doi: Doi 10.1002/Ijc.27380. PubMed PMID: ISI:000306735700035.
36. Wang J, Moore J, Laulhe S, Nantz M, Achilefu S, Kang KA. Fluorophore-gold nanoparticle complex for sensitive optical biosensing and imaging. Nanotechnology. 2012;23(9):095501. Epub 2012/02/14. doi: 10.1088/0957-4484/23/9/095501. PubMed PMID: 22327387.
37. Tu ZZ, Ma YX, Tian JM, Li H, Akers W, Achilefu S, et al. Estrogen receptor beta potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells. Journal of cancer research and clinical oncology. 2012;138(7):1091-103. doi: DOI 10.1007/s00432-011-1145-3. PubMed PMID: ISI:000305196200002.
38. Tu Z, Ma Y, Tian J, Li H, Akers W, Achilefu S, et al. Estrogen receptor beta potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells. Journal of cancer research and clinical oncology. 2012;138(7):1091-103. Epub 2012/03/09. doi: 10.1007/s00432-011-1145-3. PubMed PMID: 22398780.
39. Tu Z, Li H, Ma Y, Tang B, Tian J, Akers W, et al. The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor beta expression. Molecular and cellular biochemistry. 2012;366(1-2):111-22. Epub 2012/04/06. doi: 10.1007/s11010-012-1288-9. PubMed PMID: 22476901.
40. Tsen SW, Chapa T, Beatty W, Tsen KT, Yu D, Achilefu S. Inactivation of enveloped virus by laser-driven protein aggregation. Journal of biomedical optics. 2012;17(12):128002. Epub 2012/12/12. doi: 10.1117/1.JBO.17.12.128002. PubMed PMID: 23224114; PubMed Central PMCID: PMC3518210.
41. Tang R, Lee H, Achilefu S. Induction of pH sensitivity on the fluorescence lifetime of quantum dots by NIR fluorescent dyes. Journal of the American Chemical Society. 2012;134(10):4545-8. Epub 2012/03/01. doi: 10.1021/ja300276s. PubMed PMID: 22360301; PubMed Central PMCID: PMC3303939.
42. Solomon M, Nothdruft RE, Akers WJ, Edwards WB, Liang K, Xu B, et al. Multimodal video-rate fluorescence DOT and SPECT/CT for small animals. Biomedical Optics, OSA Technical Digest  Optical Society of America. 2012.
43. Shan L, Cui S, Du C, Wan S, Qian Z, Achilefu S, et al. A paclitaxel-conjugated adenovirus vector for targeted drug delivery for tumor therapy. Biomaterials. 2012;33(1):146-62. Epub 2011/10/01. doi: 10.1016/j.biomaterials.2011.09.025. PubMed PMID: 21959006.
44. Nothdurft R, Sarder P, Bloch S, Culver J, Achilefu S. Fluorescence lifetime imaging microscopy using near-infrared contrast agents. Journal of microscopy. 2012;247(2):202-7. Epub 2012/07/14. doi: 10.1111/j.1365-2818.2012.03634.x. PubMed PMID: 22788550; PubMed Central PMCID: PMC3607809.
45. Liu Y, York T, Akers W, Sudlow G, Gruev V, Achilefu S. Complementary fluorescence-polarization microscopy using division-of-focal-plane polarization imaging sensor. Journal of biomedical optics. 2012;17(11):116001. Epub 2012/11/03. doi: 10.1117/1.JBO.17.11.116001. PubMed PMID: 23117796; PubMed Central PMCID: PMC3484265.
46. Li H, Tu Z, An L, Qian Z, Achilefu S, Gu Y. Inhibitory effects of ERbeta on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells--prognostication for the use of ERbeta-selective therapy. Pharmaceutical biology. 2012;50(7):839-49. Epub 2012/04/11. doi: 10.3109/13880209.2011.637506. PubMed PMID: 22486657.
47. Li H, Tu Z, An L, Qian Z, Achilefu S, Gu Y. Inhibitory effects of ERbeta on proliferation, invasion, and tumor formation of MCF-7 breast cancer cells-prognostication for the use of ERbeta-selective therapy. Pharmaceutical biology. 2012;50(7):839-49. Epub 2012/04/11. doi: 10.3109/13880209.2011.637506. PubMed PMID: 22486657.
48. Lee H, Berezin MY, Tang R, Zhegalova N, Achilefu S. Pyrazole-substituted Near-infrared Cyanine Dyes Exhibit pH-dependent Fluorescence Lifetime Properties. Photochemistry and photobiology. 2012. Epub 2012/10/26. doi: 10.1111/php.12009. PubMed PMID: 23094959; PubMed Central PMCID: PMC3578979.
49. Korotcov AV, Ye Y, Chen Y, Zhang F, Huang S, Lin S, et al. Glucosamine-linked near-infrared fluorescent probes for imaging of solid tumor xenografts. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2012;14(4):443-51. Epub 2011/10/06. doi: 10.1007/s11307-011-0520-4. PubMed PMID: 21971932; PubMed Central PMCID: PMC3288187.
50. Kang KA, Wang J, O'Toole MG, Nantz M, Moore JD, Laulhe S, et al. Sensitivity enhancement of NIR fluorescence contrast agent utilizing gold nanoparticles. Advances in experimental medicine and biology. 2012;737:285-91. Epub 2012/01/20. doi: 10.1007/978-1-4614-1566-4_42. PubMed PMID: 22259115.
51. Gustafson TP, Yan Y, Newton P, Hunter DA, Achilefu S, Akers WJ, et al. A NIR dye for development of peripheral nerve targeted probes. Medchemcomm. 2012;3(6):685-90. doi: Doi 10.1039/C2md00297c. PubMed PMID: ISI:000304659600008.
52. Gustafson TP, Cao Q, Achilefu S, Berezin MY. Defining a polymethine dye for fluorescence anisotropy applications in the near-infrared spectral range. Chemphyschem : a European journal of chemical physics and physical chemistry. 2012;13(3):716-23. Epub 2012/02/04. doi: 10.1002/cphc.201100916. PubMed PMID: 22302715.
53. Guo K, Achilefu S, Berezin MY. Dating bloodstains with fluorescence lifetime measurements. Chemistry. 2012;18(5):1303-5. Epub 2012/01/13. doi: 10.1002/chem.201102935. PubMed PMID: 22238188; PubMed Central PMCID: PMC3494294.
54. Guo J, Du C, Shan L, Zhu H, Xue B, Qian Z, et al. Comparison of near-infrared fluorescent deoxyglucose probes with different dyes for tumor diagnosis in vivo. Contrast media & molecular imaging. 2012;7(3):289-301. Epub 2012/04/28. doi: 10.1002/cmmi.496. PubMed PMID: 22539399.
55. Gildersleeve JC, Wang B, Achilefu S, Tu Z, Xu M. Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies. Bioorganic & medicinal chemistry letters. 2012;22(22):6839-43. Epub 2012/10/16. doi: 10.1016/j.bmcl.2012.09.055. PubMed PMID: 23063402; PubMed Central PMCID: PMC3478784.
56. Deng DW, Chen YQ, Cao J, Tian JM, Qian ZY, Achilefu S, et al. High-Quality CuInS2/ZnS Quantum Dots for In vitro and In vivo Bioimaging. Chem Mater. 2012;24(15):3029-37. doi: Doi 10.1021/Cm3015594. PubMed PMID: ISI:000307478400022.
57. Cui SS, Chen HY, Zhu HY, Tian JM, Chi XM, Qian ZY, et al. Amphiphilic chitosan modified upconversion nanoparticles for in vivo photodynamic therapy induced by near-infrared light. J Mater Chem. 2012;22(11):4861-73. doi: Doi 10.1039/C2jm16112e. PubMed PMID: ISI:000300571400046.
58. Craft JM, De Silva RA, Lears KA, Andrews R, Liang K, Achilefu S, et al. In vitro and in vivo evaluation of a 64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer. Nuclear medicine and biology. 2012;39(5):609-16. Epub 2012/01/21. doi: 10.1016/j.nucmedbio.2011.12.004. PubMed PMID: 22261146; PubMed Central PMCID: PMC3341490.
59. Chen J, Chen HY, Cui SS, Xue B, Tian JM, Achilefu S, et al. Glucosamine derivative modified nanostructured lipid carriers for targeted tumor delivery. J Mater Chem. 2012;22(12):5770-83. doi: Doi 10.1039/C2jm15830b. PubMed PMID: ISI:000300838100070.
60. Chen H, Li S, Li B, Ren X, Mahounga DM, Cui S, et al. Folate-modified gold nanoclusters as near-infrared fluorescent probes for tumor imaging and therapy. Nanoscale. 2012;4(19):6050-64. Epub 2012/08/30. doi: 10.1039/c2nr31616a. PubMed PMID: 22930451.
61. Ardeshirpour Y, Chernomordik V, Zielinski R, Capala J, Griffiths G, Vasalatiy O, et al. In vivo fluorescence lifetime imaging monitors binding of specific probes to cancer biomarkers. PloS one. 2012;7(2):e31881. Epub 2012/03/03. doi: 10.1371/journal.pone.0031881. PubMed PMID: 22384092; PubMed Central PMCID: PMC3285647.
62. Akers WJ, Xu B, Lee H, Sudlow GP, Fields GB, Achilefu S, et al. Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe. Bioconjugate chemistry. 2012;23(3):656-63. Epub 2012/02/09. doi: 10.1021/bc300027y. PubMed PMID: 22309692; PubMed Central PMCID: PMC3310325.
63. Akers WJ, Edwards WB, Kim C, Xu B, Erpelding TN, Wang LV, et al. Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography. Translational research : the journal of laboratory and clinical medicine. 2012;159(3):175-81. Epub 2012/02/22. doi: 10.1016/j.trsl.2011.09.006. PubMed PMID: 22340767; PubMed Central PMCID: PMC3286037.
64. Achilefu S, Raghavachari R, SPIE (Society). Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications IV : 23-25 January 2012, San Francisco, California, United States. Bellingham, Wash.: SPIE; 2012.
65. Achilefu S. Rapid response activatable molecular probes for intraoperative optical image-guided tumor resection. Hepatology. 2012;56(3):1170-3. Epub 2012/06/28. doi: 10.1002/hep.25807. PubMed PMID: 22736321.
66. Ye Y, Xu B, Nikiforovich GV, Bloch S, Achilefu S. Exploring new near-infrared fluorescent disulfide-based cyclic RGD peptide analogs for potential integrin-targeted optical imaging. Bioorganic & medicinal chemistry letters. 2011;21(7):2116-20. Epub 2011/02/26. doi: 10.1016/j.bmcl.2011.01.133. PubMed PMID: 21349709; PubMed Central PMCID: PMC3056947.
67. Wang J, O'Toole M, Massey A, Biswas S, Nantz M, Achilefu S, et al. Highly specific, NIR fluorescent contrast agent with emission controlled by gold nanoparticle. Advances in experimental medicine and biology. 2011;701:149-54. Epub 2011/03/30. doi: 10.1007/978-1-4419-7756-4_21. PubMed PMID: 21445782.
68. Wang J, Achilefu S, Nantz M, Kang KA. Gold nanoparticle-fluorophore complex for conditionally fluorescing signal mediator. Analytica chimica acta. 2011;695(1-2):96-104. Epub 2011/05/24. doi: 10.1016/j.aca.2011.03.058. PubMed PMID: 21601036.
69. Solomon M, White BR, Nothdruft RE, Akers W, Sudlow G, Eggebrecht AT, et al. Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging. Biomedical optics express. 2011;2(12):3267-77. Epub 2011/12/14. doi: 10.1364/BOE.2.003267. PubMed PMID: 22162817; PubMed Central PMCID: PMC3233246.
70. Solomon M, Liu Y, Berezin MY, Achilefu S. Optical imaging in cancer research: basic principles, tumor detection, and therapeutic monitoring. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2011;20(5):397-415. Epub 2011/07/16. doi: 10.1159/000327655. PubMed PMID: 21757928.
71. Solomon M, Guo K, Sudlow GP, Berezin MY, Edwards WB, Achilefu S, et al. Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe. Journal of biomedical optics. 2011;16(6):066019. Epub 2011/07/05. doi: 10.1117/1.3594153. PubMed PMID: 21721820; PubMed Central PMCID: PMC3138800.
72. Shan L, Xue J, Guo J, Qian Z, Achilefu S, Gu Y. Improved targeting of ligand-modified adenovirus as a new near infrared fluorescence tumor imaging probe. Bioconjugate chemistry. 2011;22(4):567-81. Epub 2011/03/16. doi: 10.1021/bc100245t. PubMed PMID: 21401110.
73. Pu Y, Wang WB, Xu M, Tang GC, Budansky Y, Sharanov M, et al. Near infrared photonic finger imager for prostate cancer screening. Technology in cancer research & treatment. 2011;10(6):507-17. Epub 2011/11/10. PubMed PMID: 22066592.
74. Pu Y, Wang WB, Achilefu S, Alfano RR. Study of rotational dynamics of receptor-targeted contrast agents in cancerous and normal prostate tissues using time-resolved picosecond emission spectroscopy. Applied optics. 2011;50(10):1312-22. Epub 2011/04/05. doi: 10.1364/AO.50.001312. PubMed PMID: 21460894.
75. Liu Y, Bauer AQ, Akers WJ, Sudlow G, Liang K, Shen D, et al. Hands-free, wireless goggles for near-infrared fluorescence and real-time image-guided surgery. Surgery. 2011;149(5):689-98. Epub 2011/04/19. doi: 10.1016/j.surg.2011.02.007. PubMed PMID: 21496565; PubMed Central PMCID: PMC3079879.
76. Li W, Cai X, Kim C, Sun G, Zhang Y, Deng R, et al. Gold nanocages covered with thermally-responsive polymers for controlled release by high-intensity focused ultrasound. Nanoscale. 2011;3(4):1724-30. Epub 2011/02/16. doi: 10.1039/c0nr00932f. PubMed PMID: 21321760; PubMed Central PMCID: PMC3079502.
77. Lee H, Akers W, Bhushan K, Bloch S, Sudlow G, Tang R, et al. Near-infrared pH-activatable fluorescent probes for imaging primary and metastatic breast tumors. Bioconjugate chemistry. 2011;22(4):777-84. Epub 2011/03/11. doi: 10.1021/bc100584d. PubMed PMID: 21388195; PubMed Central PMCID: PMC3080440.
78. Lears KA, Ferdani R, Liang K, Zheleznyak A, Andrews R, Sherman CD, et al. In vitro and in vivo evaluation of 64Cu-labeled SarAr-bombesin analogs in gastrin-releasing peptide receptor-expressing prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2011;52(3):470-7. Epub 2011/02/16. doi: 10.2967/jnumed.110.082826. PubMed PMID: 21321264; PubMed Central PMCID: PMC3088991.
79. Kang KA, Wang J, Jasinski JB, Achilefu S. Fluorescence manipulation by gold nanoparticles: from complete quenching to extensive enhancement. Journal of nanobiotechnology. 2011;9:16. Epub 2011/05/17. doi: 10.1186/1477-3155-9-16. PubMed PMID: 21569249; PubMed Central PMCID: PMC3112388.
80. Berezin MY, Zhan C, Lee H, Joo C, Akers WJ, Yazdanfar S, et al. Two-photon optical properties of near-infrared dyes at 1.55 mum excitation. The journal of physical chemistry B. 2011;115(39):11530-5. Epub 2011/08/27. doi: 10.1021/jp207618e. PubMed PMID: 21866928; PubMed Central PMCID: PMC3233988.
81. Berezin MY, Guo K, Akers W, Northdurft RE, Culver JP, Teng B, et al. Near-infrared fluorescence lifetime pH-sensitive probes. Biophysical journal. 2011;100(8):2063-72. Epub 2011/04/21. doi: 10.1016/j.bpj.2011.02.050. PubMed PMID: 21504743; PubMed Central PMCID: PMC3077686.
82. Berezin MY, Guo K, Akers W, Livingston J, Solomon M, Lee H, et al. Rational approach to select small peptide molecular probes labeled with fluorescent cyanine dyes for in vivo optical imaging. Biochemistry. 2011;50(13):2691-700. Epub 2011/02/19. doi: 10.1021/bi2000966. PubMed PMID: 21329363; PubMed Central PMCID: PMC3068226.
83. Basak S, Tiwari V, Fan JD, Achilefu S, Sethi V, Biswas P. Single step aerosol synthesis of nanocomposites by aerosol routes: gamma-Fe2O3/SiO2 and their functionalization. J Mater Res. 2011;26(10):1225-33. doi: Doi 10.1557/Jmr.2011.97. PubMed PMID: ISI:000292831300006.
84. Bai M, Achilefu S. Synthesis and spectroscopy of near infrared fluorescent dyes for investigating dichromic fluorescence. Bioorganic & medicinal chemistry letters. 2011;21(1):280-4. Epub 2010/11/26. doi: 10.1016/j.bmcl.2010.11.024. PubMed PMID: 21106373; PubMed Central PMCID: PMC3010286.
85. Ardeshirpour Y, Chernomordik V, Capala J, Hassan M, Zielinsky R, Griffiths G, et al. Using in-vivo fluorescence imaging in personalized cancer diagnostics and therapy, an image and treat paradigm. Technology in cancer research & treatment. 2011;10(6):549-60. Epub 2011/11/10. PubMed PMID: 22066595.
86. Akers WJ, Kim C, Berezin M, Guo K, Fuhrhop R, Lanza GM, et al. Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. ACS nano. 2011;5(1):173-82. Epub 2010/12/22. doi: 10.1021/nn102274q. PubMed PMID: 21171567; PubMed Central PMCID: PMC3026895.
87. Achilefu S, Raghavachari R, SPIE (Society). Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications III : 24-26 January 2011, San Francisco, California, United States. Bellingham, Wash.: SPIE; 2011.
88. Zhang Z, Kao J, D'Avignon A, Achilefu S. Understanding Dichromic Fluorescence Manifested in Certain ICG Analogs. Pure and applied chemistry Chimie pure et appliquee. 2010;82(1):307-11. Epub 2010/08/17. doi: 10.1351/PAC-CON-08-12-07. PubMed PMID: 20711422; PubMed Central PMCID: PMC2920612.
89. Zhan C, Joo C, Li Q, Berezin MY, Akers WJ, Ye Y, et al., editors. Multimodal nonlinear microscopy at 1.5 μm. 2010; San Francisco, CA.
90. Yen TC, Wey SP, Liao CH, Yeh CH, Shen DW, Achilefu S, et al. Measurement of the binding parameters of annexin derivative-erythrocyte membrane interactions. Analytical biochemistry. 2010;406(1):70-9. Epub 2010/07/06. doi: 10.1016/j.ab.2010.06.048. PubMed PMID: 20599633; PubMed Central PMCID: PMC2926222.
91. Yazdanfar S, Joo C, Zhan C, Berezin MY, Akers WJ, Achilefu S. Multiphoton microscopy with near infrared contrast agents. Journal of biomedical optics. 2010;15(3):030505. Epub 2010/07/10. doi: 10.1117/1.3420209. PubMed PMID: 20614991; PubMed Central PMCID: PMC2881927.
92. Xu M, Wang F, Gildersleeve JC, Achilefu S. MAb L9E10 to blood group H2 antigen binds to colon cancer stem cells and inhibits tumor cell migration and invasion. Hybridoma (Larchmt). 2010;29(4):355-9. Epub 2010/08/19. doi: 10.1089/hyb.2010.0020. PubMed PMID: 20715995; PubMed Central PMCID: PMC3132943.
93. Wang J, Nantz MH, Achilefu S, Kang KA. FRET-like fluorophore-nanoparticle complex for highly specific cancer localization. Advances in experimental medicine and biology. 2010;662:407-13. Epub 2010/03/06. doi: 10.1007/978-1-4419-1241-1_59. PubMed PMID: 20204823.
94. Sun G, Berezin MY, Fan J, Lee H, Ma J, Zhang K, et al. Bright fluorescent nanoparticles for developing potential optical imaging contrast agents. Nanoscale. 2010;2(4):548-58. Epub 2010/07/21. doi: 10.1039/b9nr00304e. PubMed PMID: 20644758.
95. Smith BA, Akers WJ, Leevy WM, Lampkins AJ, Xiao S, Wolter W, et al. Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc(II)-dipicolylamine probe for anionic cell surfaces. Journal of the American Chemical Society. 2010;132(1):67-9. Epub 2009/12/18. doi: 10.1021/ja908467y. PubMed PMID: 20014845; PubMed Central PMCID: PMC2805267.
96. Liu Y, Solomon M, Achilefu S. Perspectives and potential applications of nanomedicine in breast and prostate cancer. Medicinal research reviews. 2010. Epub 2010/11/11. doi: 10.1002/med.20233. PubMed PMID: 21064186.
97. Liu F, Deng D, Chen X, Qian Z, Achilefu S, Gu Y. Folate-polyethylene glycol conjugated near-infrared fluorescence probe with high targeting affinity and sensitivity for in vivo early tumor diagnosis. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2010;12(6):595-607. Epub 2010/04/09. doi: 10.1007/s11307-010-0305-1. PubMed PMID: 20376571.
98. Kim C, Erpelding TN, Maslov K, Jankovic L, Akers WJ, Song L, et al. Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes. Journal of biomedical optics. 2010;15(4):046010. Epub 2010/08/31. doi: 10.1117/1.3469829. PubMed PMID: 20799812; PubMed Central PMCID: PMC2937045.
99. Guo K, Berezin MY, Zheng J, Akers W, Lin F, Teng B, et al. Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging. Chem Commun (Camb). 2010;46(21):3705-7. Epub 2010/04/15. doi: 10.1039/c000536c. PubMed PMID: 20390151; PubMed Central PMCID: PMC2975539.
100. Chen R, Parry JJ, Akers WJ, Berezin MY, El Naqa IM, Achilefu S, et al. Multimodality imaging of gene transfer with a receptor-based reporter gene. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010;51(9):1456-63. Epub 2010/08/20. doi: 10.2967/jnumed.109.063586. PubMed PMID: 20720053; PubMed Central PMCID: PMC2981350.
101. Berezin MY, Achilefu S. Fluorescence lifetime measurements and biological imaging. Chemical reviews. 2010;110(5):2641-84. Epub 2010/04/02. doi: 10.1021/cr900343z. PubMed PMID: 20356094; PubMed Central PMCID: PMC2924670.
102. Bai MF, Achilefu S. Synthesis of functional near infrared pyrrolopyrrole cyanine dyes for optical and photoacoustic imaging. Heterocycl Commun. 2010;16(4-6):213-6. doi: Doi 10.1515/Hc.2010.006. PubMed PMID: ISI:000297077500002.
103. Akers WJ, Zhang Z, Berezin M, Ye Y, Agee A, Guo K, et al. Targeting of alpha(nu)beta(3)-integrins expressed on tumor tissue and neovasculature using fluorescent small molecules and nanoparticles. Nanomedicine (Lond). 2010;5(5):715-26. Epub 2010/07/29. doi: 10.2217/nnm.10.38. PubMed PMID: 20662643; PubMed Central PMCID: PMC2914325.
104. Achilefu SI, Raghavachari R, SPIE (Society). Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applicaitons II : 25-27 January 2010, San Francisco, California, United States. Bellingham, Wash.: SPIE; 2010.
105. Achilefu S, Xu M. Monoclonal Antibody L9E10 to Blood Group H2 Antigen. Hybridoma. 2010;29(4):374-. doi: DOI 10.1089/hyb.2010.0046.MAb. PubMed PMID: ISI:000280990500019.
106. Achilefu S. Introduction to concepts and strategies for molecular imaging. Chemical reviews. 2010;110(5):2575-8. Epub 2010/04/27. doi: 10.1021/cr1001113. PubMed PMID: 20415501.
107. Achilefu S. The insatiable quest for near-infrared fluorescent probes for molecular imaging. Angew Chem Int Ed Engl. 2010;49(51):9816-8. Epub 2010/11/20. doi: 10.1002/anie.201005684. PubMed PMID: 21089086; PubMed Central PMCID: PMC3046463.
108. Zhang Z, Fan J, Cheney PP, Berezin MY, Edwards WB, Akers WJ, et al. Activatable molecular systems using homologous near-infrared fluorescent probes for monitoring enzyme activities in vitro, in cellulo, and in vivo. Molecular pharmaceutics. 2009;6(2):416-27. Epub 2009/09/01. doi: 10.1021/mp800264k. PubMed PMID: 19718795; PubMed Central PMCID: PMC2913166.
109. Wei L, Ye Y, Wadas TJ, Lewis JS, Welch MJ, Achilefu S, et al. (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity. Nuclear medicine and biology. 2009;36(3):277-85. Epub 2009/03/28. doi: 10.1016/j.nucmedbio.2008.12.008. PubMed PMID: 19324273; PubMed Central PMCID: PMC2692938.
110. Qian H, Gu Y, Wang M, Achilefu S. Optimization of the near-infrared fluorescence labeling for in vivo monitoring of a protein drug distribution in animal model. Journal of fluorescence. 2009;19(2):277-84. Epub 2008/09/02. doi: 10.1007/s10895-008-0413-3. PubMed PMID: 18758925.
111. Odonkor CA, Achilefu S. Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy. Cancer investigation. 2009;27(4):417-29. Epub 2009/02/26. doi: 10.1080/07357900802438585. PubMed PMID: 19241192; PubMed Central PMCID: PMC2914624.
112. Nothdurft RE, Patwardhan SV, Akers W, Ye Y, Achilefu S, Culver JP. In vivo fluorescence lifetime tomography. Journal of biomedical optics. 2009;14(2):024004. Epub 2009/05/02. doi: 10.1117/1.3086607. PubMed PMID: 19405734.
113. Lee H, Berezin MY, Guo K, Kao J, Achilefu S. Near-infrared fluorescent pH-sensitive probes via unexpected barbituric acid mediated synthesis. Organic letters. 2009;11(1):29-32. Epub 2008/12/09. doi: 10.1021/ol802363x. PubMed PMID: 19061361; PubMed Central PMCID: PMC2725187.
114. Lee H, Akers WJ, Cheney PP, Edwards WB, Liang K, Culver JP, et al. Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe. Journal of biomedical optics. 2009;14(4):040507. Epub 2009/09/04. doi: 10.1117/1.3207156. PubMed PMID: 19725712; PubMed Central PMCID: PMC2916017.
115. Kelly TS, Ferdani R, Liang K, Andrews R, Sherman CD, Achilefu S, et al. EVALUATION OF A Cu-64-LABELED SarAr CONJUGATED BOMBESIN ANALOG FOR DETECTION OF GASTRIN-RELEASING PEPTIDE RECEPTOR POSITIVE TUMORS. J Labelled Compd Rad. 2009;52:S352-S. PubMed PMID: ISI:000268724900353.
116. Hsu KM, Pratt JR, Akers WJ, Achilefu SI, Yokoyama WM. Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. The Journal of general virology. 2009;90(Pt 1):33-43. Epub 2008/12/18. doi: 10.1099/vir.0.006668-0. PubMed PMID: 19088270; PubMed Central PMCID: PMC2762738.
117. Goiffon RJ, Akers WJ, Berezin MY, Lee H, Achilefu S. Dynamic noninvasive monitoring of renal function in vivo by fluorescence lifetime imaging. Journal of biomedical optics. 2009;14(2):020501. Epub 2009/05/02. doi: 10.1117/1.3095800. PubMed PMID: 19405707; PubMed Central PMCID: PMC2914690.
118. Fiamengo AL, Ye Y, Achilefu S, Anderson CJ. In Vitro and in Vivo Evaluation of Structurally Diverse Cu-64-Labeled Rgd Peptides for Pet Imaging of Alpha V Beta 3 Expression. J Labelled Compd Rad. 2009;52:S33-S. PubMed PMID: ISI:000268724900034.
119. Edwards WB, Akers WJ, Ye Y, Cheney PP, Bloch S, Xu B, et al. Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide. Molecular imaging. 2009;8(2):101-10. Epub 2009/04/29. PubMed PMID: 19397855; PubMed Central PMCID: PMC2975541.
120. Berezin MY, Lee H, Akers W, Guo K, Goiffon RJ, Almutairi A, et al. Engineering NIR dyes for fluorescent lifetime contrast. Conference proceedings :  Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2009;2009:114-7. Epub 2009/12/08. doi: 10.1109/IEMBS.2009.5334834. PubMed PMID: 19964923.
121. Berezin MY, Kao J, Achilefu S. pH-dependent optical properties of synthetic fluorescent imidazoles. Chemistry. 2009;15(14):3560-6. Epub 2009/02/13. doi: 10.1002/chem.200801784. PubMed PMID: 19212987; PubMed Central PMCID: PMC2844652.
122. Berezin MY, Guo K, Teng B, Edwards WB, Anderson CJ, Vasalatiy O, et al. Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye. Journal of the American Chemical Society. 2009;131(26):9198-200. Epub 2009/06/12. doi: 10.1021/ja903685b. PubMed PMID: 19514722; PubMed Central PMCID: PMC2715832.
123. Berezin MY, Akers WJ, Guo K, Fischer GM, Daltrozzo E, Zumbusch A, et al. Long fluorescence lifetime molecular probes based on near infrared pyrrolopyrrole cyanine fluorophores for in vivo imaging. Biophysical journal. 2009;97(9):L22-4. Epub 2009/11/04. doi: 10.1016/j.bpj.2009.08.022. PubMed PMID: 19883579; PubMed Central PMCID: PMC2770609.
124. Akers WJ, Berezin MY, Lee H, Achilefu S, editors. In Vivoimaging with near-infrared fluorescence lifetime contrast. 2009; San Jose, CA.
125. Achilefu S, Raghavachari R, SPIE (Society). Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications : 26-29 January 2009, San Jose, California, United States. Bellingham, Wash.: SPIE; 2009.
126. Zhang Z, Berezin MY, Kao JL, d'Avignon A, Bai M, Achilefu S. Near-infrared dichromic fluorescent carbocyanine molecules. Angew Chem Int Ed Engl. 2008;47(19):3584-7. Epub 2008/04/04. doi: 10.1002/anie.200800475. PubMed PMID: 18386274.
127. Ye Y, Bloch S, Xu B, Achilefu S. Novel near-infrared fluorescent integrin-targeted DFO analogue. Bioconjugate chemistry. 2008;19(1):225-34. Epub 2007/11/28. doi: 10.1021/bc7003022. PubMed PMID: 18038965; PubMed Central PMCID: PMC2631379.
128. Ye Y, Bloch S, Achilefu S, editors. Novel optical contrast agents containing both DFO and multi-RGD peptides. 2008; Beijing.
129. Xu M, Yuan Y, Xia Y, Achilefu S. Monoclonal antibody CC188 binds a carbohydrate epitope expressed on the surface of both colorectal cancer stem cells and their differentiated progeny. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008;14(22):7461-9. Epub 2008/11/18. doi: 10.1158/1078-0432.CCR-07-4430. PubMed PMID: 19010863.
130. Wadas TJ, Eiblmaier M, Zheleznyak A, Sherman CD, Ferdani R, Liang K, et al. Preparation and biological evaluation of 64Cu-CB-TE2A-sst2-ANT, a somatostatin antagonist for PET imaging of somatostatin receptor-positive tumors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008;49(11):1819-27. Epub 2008/10/18. doi: 10.2967/jnumed.108.054502. PubMed PMID: 18927338; PubMed Central PMCID: PMC2794832.
131. Pu Y, Wang WB, Das BB, Achilefu S, Alfano RR. Time-resolved fluorescence polarization dynamics and optical imaging of Cytate: a prostate cancer receptor-targeted contrast agent. Applied optics. 2008;47(13):2281-9. Epub 2008/05/02. PubMed PMID: 18449292.
132. Odonkor CA, Achilefu S. Differential activity of caspase-3 regulates susceptibility of lung and breast tumor cell lines to Paclitaxel. The open biochemistry journal. 2008;2:121-8. Epub 2009/02/25. doi: 10.2174/1874091X00802010121. PubMed PMID: 19238186; PubMed Central PMCID: PMC2627519.
133. Lee H, Mason JC, Achilefu S. Synthesis and spectral properties of near-infrared aminophenyl-, hydroxyphenyl-, and phenyl-substituted heptamethine cyanines. The Journal of organic chemistry. 2008;73(2):723-5. Epub 2007/12/22. doi: 10.1021/jo701793h. PubMed PMID: 18095702.
134. Lee H, Berezin MY, Henary M, Strekowski L, Achilefu S. Fluorescence lifetime properties of near-infrared cyanine dyes in relation to their structures. Journal of photochemistry and photobiology A, Chemistry. 2008;200(2-3):438-44. Epub 2009/12/18. doi: 10.1016/j.jphotochem.2008.09.008. PubMed PMID: 20016664; PubMed Central PMCID: PMC2630462.
135. Hirche TO, Benabid R, Deslee G, Gangloff S, Achilefu S, Guenounou M, et al. Neutrophil elastase mediates innate host protection against Pseudomonas aeruginosa. J Immunol. 2008;181(7):4945-54. Epub 2008/09/20. PubMed PMID: 18802098.
136. Fiamengo AL, Ye YP, Achilefu S, Anderson CJ. NUCL 37-Binding affinity and cellular internalization of alpha v beta 3 targeting ligands for molecular imaging of cancer and cardiovascular disease. Abstr Pap Am Chem S. 2008;236. PubMed PMID: ISI:000270256305739.
137. Edwards WB, Xu B, Akers W, Cheney PP, Liang K, Rogers BE, et al. Agonist-antagonist dilemma in molecular imaging: evaluation of a monomolecular multimodal imaging agent for the somatostatin receptor. Bioconjugate chemistry. 2008;19(1):192-200. Epub 2007/11/21. doi: 10.1021/bc700291m. PubMed PMID: 18020401; PubMed Central PMCID: PMC2539107.
138. Culver J, Akers W, Achilefu S. Multimodality molecular imaging with combined optical and SPECT/PET modalities. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008;49(2):169-72. Epub 2008/01/18. doi: 10.2967/jnumed.107.043331. PubMed PMID: 18199608.
139. Almutairi A, Guillaudeu SJ, Berezin MY, Achilefu S, Frechet JM. Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging. Journal of the American Chemical Society. 2008;130(2):444-5. Epub 2007/12/20. doi: 10.1021/ja078147e. PubMed PMID: 18088125.
140. Almutairi A, Akers WJ, Berezin MY, Achilefu S, Frechet JM. Monitoring the biodegradation of dendritic near-infrared nanoprobes by in vivo fluorescence imaging. Molecular pharmaceutics. 2008;5(6):1103-10. Epub 2009/05/13. PubMed PMID: 19434857; PubMed Central PMCID: PMC2772156.
141. Akers WJ, Berezin MY, Lee H, Achilefu S. Predicting in vivo fluorescence lifetime behavior of near-infrared fluorescent contrast agents using in vitro measurements. Journal of biomedical optics. 2008;13(5):054042. Epub 2008/11/22. doi: 10.1117/1.2982535. PubMed PMID: 19021422; PubMed Central PMCID: PMC2744956.
142. Achilefu S, Ye YP, Zhang ZR, Lee H, Fan JD, Liang KX, et al. INOR 438-Chemical and biochemical contrast strategies for optical imaging of molecular processes in vivo. Abstr Pap Am Chem S. 2008;236. PubMed PMID: ISI:000270256306422.
143. Achilefu S, Bornhop DJ, Raghavachari R, SPIE (Society). Molecular probes for biomedical applications II : 21-22 January 2008, San Jose, California, USA. Bellingham, Wash.: SPIE; 2008.
144. Achilefu S, Berezin M, Akers W, Lee H, Bai MF, Bloch S, et al. ANYL 272-Fluorescence lifetime imaging of tumors using near infrared fluorescent molecular probes. Abstr Pap Am Chem S. 2008;236. PubMed PMID: ISI:000270256301315.
145. Sprague JE, Kitaura H, Zou W, Ye Y, Achilefu S, Weilbaecher KN, et al. Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2007;48(2):311-8. Epub 2007/02/03. PubMed PMID: 17268030; PubMed Central PMCID: PMC2711534.
146. Shen D, Liang K, Ye Y, Tetteh E, Achilefu S. Modulation of nuclear internalization of Tat peptides by fluorescent dyes and receptor-avid peptides. FEBS letters. 2007;581(9):1793-9. Epub 2007/04/10. doi: 10.1016/j.febslet.2007.03.067. PubMed PMID: 17416362; PubMed Central PMCID: PMC1934384.
147. Pu Y, Wang WB, Achilefu S, Das BB, Tang GC, Sriramoju V, et al. Time-resolved fluorescence polarization anisotropy and optical imaging of Cybesin in cancerous and normal prostate tissues. Opt Commun. 2007;274(1):260-7. doi: DOI 10.1016/j.optcom.2007.01.078. PubMed PMID: ISI:000246191500041.
148. Nikiforovich GV, Marshall GR, Achilefu S. Molecular modeling suggests conformational scaffolds specifically targeting five subtypes of somatostatin receptors. Chemical biology & drug design. 2007;69(3):163-9. Epub 2007/04/20. doi: 10.1111/j.1747-0285.2007.00493.x. PubMed PMID: 17441902.
149. Berezin MY, Lee H, Akers W, Nikiforovich G, Achilefu S. Ratiometric analysis of fluorescence lifetime for probing binding sites in albumin with near-infrared fluorescent molecular probes. Photochemistry and photobiology. 2007;83(6):1371-8. Epub 2007/11/22. doi: 10.1111/j.1751-1097.2007.00173.x. PubMed PMID: 18028211.
150. Berezin MY, Lee H, Akers W, Achilefu S. Near infrared dyes as lifetime solvatochromic probes for micropolarity measurements of biological systems. Biophysical journal. 2007;93(8):2892-9. Epub 2007/06/19. doi: 10.1529/biophysj.107.111609. PubMed PMID: 17573433; PubMed Central PMCID: PMC1989699.
151. Berezin M, Achilefu S. Novel synthon for incorporating 1,3-dimethyl imidazolium group into molecular architecture. Tetrahedron letters. 2007;48(7):1195-9. Epub 2007/04/10. doi: 10.1016/j.tetlet.2006.12.051. PubMed PMID: 17417670; PubMed Central PMCID: PMC1849869.
152. Almutairi A, Rossin R, Berezin M, Achilefu S, Welch MJ, Wooley KL, et al. AEI 124-Designing biocompatible and activatable nanoscale carriers for bioactive agents. Abstr Pap Am Chem S. 2007;234. PubMed PMID: ISI:000207593900035.
153. Almutairi A, Berezin M, Rossin R, Achilefu S, Welch MJ, Hawker CJ, et al. COLL 39-Nanoscale carriers for diagnosis and therapy. Abstr Pap Am Chem S. 2007;234. PubMed PMID: ISI:000207593902231.
154. Akers W, Lesage F, Holten D, Achilefu S. In vivo resolution of multiexponential decays of multiple near-infrared molecular probes by fluorescence lifetime-gated whole-body time-resolved diffuse optical imaging. Molecular imaging. 2007;6(4):237-46. Epub 2007/08/23. PubMed PMID: 17711779.
155. Achilefu S, Society of Photo-optical Instrumentation Engineers. Genetically engineered and optical probes for biomedical applications IV : 23-24 January 2007, San Jose, California, USA. Bellingham, Wash.: SPIE; 2007.
156. Achilefu S. Biophotonics - Unravelling animal anatomy. Nat Photonics. 2007;1(9):496-7. doi: DOI 10.1038/nphoton.2007.153. PubMed PMID: ISI:000249609100006.
157. Ye Y, Bloch S, Xu B, Achilefu S. Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. Journal of medicinal chemistry. 2006;49(7):2268-75. Epub 2006/03/31. doi: 10.1021/jm050947h. PubMed PMID: 16570923; PubMed Central PMCID: PMC2525663.
158. Ye Y, Bloch S, Xu B, Achilefu S, editors. Synthesis and evaluation of two NIR fluorescent cyclic RGD penta-peptides for targeting integrins. 2006; San Jose, CA.
159. Wadas TJ, Sprague JE, Deng H, Ye Y, Achilefu S, Weilbaecher K, et al. Targeting the alpha(v)beta(3) integrin on osteoclasts using 64CU-CB-TE2A-C(RGDYK) for MicroPET/microCT imaging of osteolytic bone metastases. Cancer Treat Rev. 2006;32:S20-S. PubMed PMID: ISI:000243154100030.
160. Wadas TJ, Sprague JE, Deng H, Ye Y, Achilefu S, Weilbaecher K, et al. Monitoring the effects of bisphosphonate treatment in a mouse model of osteolytic bone disease using microPET and microCT. Eur J Nucl Med Mol I. 2006;33:S227-S. PubMed PMID: ISI:000202967400677.
161. Sprague JE, Li WP, Liang K, Achilefu S, Anderson CJ. In vitro and in vivo investigation of matrix metalloproteinase expression in metastatic tumor models. Nuclear medicine and biology. 2006;33(2):227-37. Epub 2006/03/21. doi: 10.1016/j.nucmedbio.2005.10.011. PubMed PMID: 16546677.
162. Shen D, Liang K, Ye Y, Tetteh E, Achilefu S, editors. Preliminary study on the inhibition of nuclear internalization of Tat peptides by conjugation with a receptor-specific peptide and fluorescent dyes. 2006; San Jose, CA.
163. Patwardhan SV, Bloch S, Achilefu S, Culver JP. Quantitative small animal fluorescence tomography using an ultrafast gated image intensifier. Conference proceedings :  Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2006;1:2675-8. Epub 2007/10/20. doi: 10.1109/IEMBS.2006.259942. PubMed PMID: 17946130.
164. Lee H, Mason JC, Achilefu S. Heptamethine cyanine dyes with a robust C-C bond at the central position of the chromophore. The Journal of organic chemistry. 2006;71(20):7862-5. Epub 2006/09/26. doi: 10.1021/jo061284u. PubMed PMID: 16995699.
165. Bloch S, Xu BG, Ye YP, Liang KX, Nikiforovich GV, Achilefu S. Targeting beta-3 integrin using a linear hexapeptide labeled with a near-infrared fluorescent molecular probe. Molecular pharmaceutics. 2006;3(5):539-57. doi: Doi 10.1021/Mp0600642. PubMed PMID: ISI:000203539700009.
166. Bloch S, Xu B, Ye Y, Liang K, Nikiforovich GV, Achilefu S. Targeting Beta-3 integrin using a linear hexapeptide labeled with a near-infrared fluorescent molecular probe. Molecular pharmaceutics. 2006;3(5):539-49. Epub 2006/10/03. doi: 10.1021/mp0600642. PubMed PMID: 17009853.
167. Bloch S, Xu B, Ye Y, Liang K, Nikiforovich GV, Achilefu S. The linear grd peptide labeled with a fluorescent problem interacts with beta 3 integrin. J Pept Sci. 2006;12:230-. PubMed PMID: ISI:000239905600584.
168. Bloch S, Xu B, Ye Y, Liang K, Achilefu S, editors. Internalization of RGD peptide conjugates of near-infrared fluorescent probes in different cell lines occurs via different integrin receptor subtypes. 2006; San Jose, CA.
169. Achilefu S, Bornhop DJ, Raghavachari R, Society of Photo-optical Instrumentation Engineers. Optical molecular probes for biomedical applications : 22 -24 January 2006, San Jose, California, USA. Bellingham, Wash.: SPIE; 2006.
170. Zhang Z, Liang K, Bloch S, Berezin M, Achilefu S. Monomolecular multimodal fluorescence-radioisotope imaging agents. Bioconjugate chemistry. 2005;16(5):1232-9. Epub 2005/09/22. doi: 10.1021/bc050136s. PubMed PMID: 16173803.
171. Zhang Z, Achilefu S. Spectral properties of pro-multimodal imaging agents derived from a NIR dye and a metal chelator. Photochemistry and photobiology. 2005;81(6):1499-504. Epub 2005/08/27. doi: 10.1562/2005-06-08-RA-568. PubMed PMID: 16120005.
172. Zhang Z, Achilefu S. Design, synthesis and evaluation of near-infrared fluorescent pH indicators in a physiologically relevant range. Chem Commun (Camb). 2005(47):5887-9. Epub 2005/12/01. doi: 10.1039/b512315a. PubMed PMID: 16317464.
173. Ye Y, Bloch S, Kao J, Achilefu S. Multivalent carbocyanine molecular probes: synthesis and applications. Bioconjugate chemistry. 2005;16(1):51-61. Epub 2005/01/20. doi: 10.1021/bc049790i. PubMed PMID: 15656575.
174. Pu Y, Wang WB, Tang GC, Zeng F, Achilefu S, Vitenson JH, et al. Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent. Technology in cancer research & treatment. 2005;4(4):429-36. Epub 2005/07/21. PubMed PMID: 16029061.
175. Patwardhan S, Bloch S, Achilefu S, Culver J. Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice. Optics express. 2005;13(7):2564-77. Epub 2005/04/04. PubMed PMID: 19495147.
176. Chen Y, Gryshuk A, Achilefu S, Ohulchansky T, Potter W, Zhong T, et al. A novel approach to a bifunctional photosensitizer for tumor imaging and phototherapy. Bioconjugate chemistry. 2005;16(5):1264-74. Epub 2005/09/22. doi: 10.1021/bc050177o. PubMed PMID: 16173807.
177. Bloch S, Lesage F, McIntosh L, Gandjbakhche A, Liang K, Achilefu S. Whole-body fluorescence lifetime imaging of a tumor-targeted near-infrared molecular probe in mice. Journal of biomedical optics. 2005;10(5):054003. Epub 2005/11/19. doi: 10.1117/1.2070148. PubMed PMID: 16292963.
178. Achilefu S, Contag CH, Savitsky AP, Weissleder R. Chemical and genetic sensors in biomedical research. Journal of biomedical optics. 2005;10(4). doi: Artn 041201
Doi 10.1117/1.2011409. PubMed PMID: ISI:000232799200001.
179. Achilefu S, Bloch S, Markiewicz MA, Zhong T, Ye Y, Dorshow RB, et al. Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(22):7976-81. Epub 2005/05/25. doi: 10.1073/pnas.0503500102. PubMed PMID: 15911748; PubMed Central PMCID: PMC1142399.
180. Zhang Z, Achilefu S. Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes. Organic letters. 2004;6(12):2067-70. Epub 2004/06/05. doi: 10.1021/ol049258a. PubMed PMID: 15176820.
181. Ye YP, Achilefu S. Novel fluorescent carbocyanine-based molecular beacons: Synthesis and metal binding properties. Abstr Pap Am Chem S. 2004;228:U872-U. PubMed PMID: ISI:000223712803646.
182. Ye Y, Bloch S, Achilefu S. Polyvalent carbocyanine molecular beacons for molecular recognitions. Journal of the American Chemical Society. 2004;126(25):7740-1. Epub 2004/06/24. doi: 10.1021/ja049441z. PubMed PMID: 15212497.
183. Sprague JE, Peng Y, Sun X, Weisman GR, Wong EH, Achilefu S, et al. Preparation and biological evaluation of copper-64-labeled tyr3-octreotate using a cross-bridged macrocyclic chelator. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004;10(24):8674-82. Epub 2004/12/30. doi: 10.1158/1078-0432.CCR-04-1084. PubMed PMID: 15623652.
184. Achilefu S, Ye YP, Bloch S, Zhang ZR, Berezin M, Liang KX. Development of contrast effectors for optical and multimodal imaging of tumors. Abstr Pap Am Chem S. 2004;228:U824-U. PubMed PMID: ISI:000223712803344.
185. Achilefu S. Lighting up tumors with receptor-specific optical molecular probes. Technology in cancer research & treatment. 2004;3(4):393-409. Epub 2004/07/24. PubMed PMID: 15270591.
186. Ye Y, Li WP, Anderson CJ, Kao J, Nikiforovich GV, Achilefu S. Synthesis and characterization of a macrocyclic near-infrared optical scaffold. Journal of the American Chemical Society. 2003;125(26):7766-7. Epub 2003/06/26. doi: 10.1021/ja034186o. PubMed PMID: 12822971.
187. Dalm VA, van Hagen PM, van Koetsveld PM, Achilefu S, Houtsmuller AB, Pols DH, et al. Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells. American journal of physiology Endocrinology and metabolism. 2003;285(2):E344-53. Epub 2003/04/10. doi: 10.1152/ajpendo.00048.2003. PubMed PMID: 12684217.
188. Chen Y, Zheng G, Zhang ZH, Blessington D, Zhang M, Li H, et al. Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studies. Optics letters. 2003;28(21):2070-2. Epub 2003/11/01. PubMed PMID: 14587818.
189. Achilefu S, Srinivasan A, Schmidt MA, Jimenez HN, Bugaj JE, Erion JL. Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors. Journal of medicinal chemistry. 2003;46(15):3403-11. Epub 2003/07/11. doi: 10.1021/jm030081k. PubMed PMID: 12852770.
190. Lewis JS, Achilefu S, Garbow JR, Laforest R, Welch MJ. Small animal imaging. current technology and perspectives for oncological imaging. Eur J Cancer. 2002;38(16):2173-88. Epub 2002/10/22. PubMed PMID: 12387842.
191. Achilefu S, Jimenez HN, Dorshow RB, Bugaj JE, Webb EG, Wilhelm RR, et al. Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents. Journal of medicinal chemistry. 2002;45(10):2003-15. Epub 2002/05/03. PubMed PMID: 11985468.
192. Achilefu S, Dorshow RB. Dynamic and continuous monitoring of renal and hepatic functions with exogenous markers. Top Curr Chem. 2002;222:31-72. PubMed PMID: ISI:000177591600002.
193. Bugaj JE, Achilefu S, Dorshow RB, Rajagopalan R. Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform. Journal of biomedical optics. 2001;6(2):122-33. Epub 2001/05/29. doi: 10.1117/1.1352748. PubMed PMID: 11375721.
194. Rajagopalan R, Uetrecht P, Bugaj JE, Achilefu SA, Dorshow RB. Stabilization of the optical tracer agent indocyanine green using noncovalent interactions. Photochemistry and photobiology. 2000;71(3):347-50. Epub 2000/03/25. PubMed PMID: 10732454.
195. Achilefu S, Wilhelm RR, Jimenez HN, Schmidt MA, Srinivasan A. A new method for the synthesis of tri-tert-butyl diethylenetriaminepentaacetic acid and its derivatives. The Journal of organic chemistry. 2000;65(5):1562-5. Epub 2000/05/18. PubMed PMID: 10814125.
196. Achilefu S, Dorshow RB, Bugaj JE, Rajagopalan R. Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging. Investigative radiology. 2000;35(8):479-85. Epub 2000/08/18. PubMed PMID: 10946975.
197. Nair AC, Yu SJ, Welsh WJ, Achilefu S. Computational study of somatostatin analogs: 3-D QSAR prediction of somatostatin receptor subpipe 2 (SST2) binding affinities. Abstr Pap Am Chem S. 1999;218:U506-U. PubMed PMID: ISI:000082033901540.
198. Gerardin-Charbonnier C, Auberger S, Molina L, Achilefu S, Manresa MA, Vinardell P, et al. Preparation and antibiotic activity of monobactam analogues of nocardicins. Preparative biochemistry & biotechnology. 1999;29(3):257-72. Epub 1999/08/04. doi: 10.1080/10826069908544928. PubMed PMID: 10431930.
199. Bugaj JE, Erion JL, Schmidt MA, Wilhelm RR, Achilefu SI, Srinivasan A. Biodistribution and radiotherapy studies using samarium-153 and lutetium-177 DTPA conjugates of Y-3-Octreotate. Journal of Nuclear Medicine. 1999;40(5):223p-4p. PubMed PMID: ISI:000080105800911.
200. Molina L, Perani A, Infante MR, Manresa MA, Maugras M, Achilefu S, et al. Bioactive Surfactants Containing a Beta-Lactam Group - Synthesis and Properties. J Chem Soc Chem Comm. 1995(12):1279-80. doi: Doi 10.1039/C39950001279. PubMed PMID: ISI:A1995RE94400042.
201. Achilefu S, Mansuy L, Selve C, Thiebaut S. Synthesis of 2h,2h-Perfluoroalkyl and 2h-Perfluoroalkenyl Carboxylic-Acids and Amides. J Fluorine Chem. 1995;70(1):19-26. doi: Doi 10.1016/0022-1139(94)03084-D. PubMed PMID: ISI:A1995QA06800005.
202. Achilefu SA, White DJ, Matondo SOC, Jones WB, Ashcroft MJ, Maw SJ, et al. From Pockets Full of Metals to Empty Pockets. Abstr Pap Am Chem S. 1994;207:455-INOR. PubMed PMID: ISI:A1994MY95403215.
203. Achilefu S, Selve C, Stebe MJ, Ravey JC, Delpuech JJ. Monodisperse Perfluoroalkyl Oxyethylene Nonionic Surfactants with Methoxy Capping - Synthesis and Phase-Behavior of Water Surfactant Binary-Systems. Langmuir. 1994;10(7):2131-8. doi: Doi 10.1021/La00019a019. PubMed PMID: ISI:A1994NY16300019.
204. Achilefu SA, Slade P, Snodin M, Cooper SR. Self-Emulsifying Tripodal Fluoroalkyl Surfactants for Artificial Blood - a Convergent Synthesis. Abstr Pap Am Chem S. 1993;205:51-Coll. PubMed PMID: ISI:A1993KQ98101360.
205. Wassermann H, Azim E, Coudert G, Achilefu S, Selve C. Symmetrical Di-Alkyl or Tetra-Alkyl Substituted Monodisperse Polyoxyethyleneglycols - Synthesis and Surface-Properties. J Chem Soc Perk T 2. 1992(11):2043-7. doi: Doi 10.1039/P29920002043. PubMed PMID: ISI:A1992JY85600030.
206. Selve C, Delestre C, Achilefu S, Maugras M, Attioui F. Synthesis and Evaluation of the Properties of Fluorinated Amphiphilic Amides of 2,2-Bis(Hydroxymethyl)Propionic Acid. J Chem Soc Chem Comm. 1991(13):863-4. doi: Doi 10.1039/C39910000863. PubMed PMID: ISI:A1991FV83500014.
207. Selve C, Achilefu S, Mansuy L. A Novel Procedure for the Synthesis of Ether-Bridged Perfluoro Nonionic Surfactants. Synthetic Commun. 1990;20(6):799-807. doi: Doi 10.1080/00397919008052325. PubMed PMID: ISI:A1990DA72800003.
208. Selve C, Achilefu S. Synthesis of Monodisperse Perfluoroalkyl Oxyethylene Surfactants with Methoxy Capping - Surfactants of High Chemical Inertness. J Chem Soc Chem Comm. 1990(13):911-2. doi: Doi 10.1039/C39900000911. PubMed PMID: ISI:A1990DM89800010.

Berezin Publications
2014
Zhegalova, NG., He, S.,  Zhou, H., Kim, DM and Berezin, MY "Minimization of self-quenching fluorescence on dyes conjugated to biomolecules with multiple labeling sites via asymmetrically charged NIR fluorophores," Contrast Media and Molecular Imaging (accepted Nov  2013)
2013
Zhegalova NG., Gonzales G., and Berezin MY., Synthesis of nitric oxide probes with fluorescence lifetime sensitivity" Organic & Biomolecular Chemistry, 2013, 11 (47), 8228 - 8234
Cao Q., Zhegalova NG., Wang ST., Akers WJ., Berezin MY., Multi-spectral imaging in the extended NIR window based on endogenous chromophores, J. Biomed. Optics, 2013, 18(10), 101318
Mathieu L., Viger ML., Sheng W., McFearin CL., Berezin MY., Almutairi A., Application of Time-Resolved Fluorescence for Direct and Continuous Probing of Release from Polymeric Delivery Vehicles, Journal of Controlled Release, 2013, 171(3), 308–314
Wang W., Zhegalova NG., Gustafson TP.,  Zhou A., Sher J., Achilefu S., Berezin OY., Berezin MY.  Sensitivity of activatable reactive oxygen species probes by fluorescence spectroelectrochemistry, Analyst, 2013, 138, 4363-4369
Gustafson TP., Dergunov SA.,  Akers WJ., Chen Q.,  Magalotti S.,  Achilefu S.,  Pinkhassik E., Berezin MY., Blood Triggered Rapid Release Porous Nanocapsules,  RCS Advances, 2013,3, 5547-5555
Magalotti S., Gustafson TP., Cao Q., Abendschein D.,  Pierce R., Berezin MY., Akers  WJ. Evaluation of Inflammatory Response to Acute Ischemia Using Near-Infrared Fluorescent Reactive Oxygen Sensors, Mol Imaging Biol , 2013, 15 (4),  page 423-430
Gustafson T., Cao Q., Wang S., Berezin MY. Design of Irreversible Optical Nanothermometers for Thermal Ablations, Chem Commun, 2013,49, 680-682
Lee H., Berezin MY., Tang R., Zhegalova N., Achilefu S. Pyrazole-substituted Near-infrared Cyanine Dyes Exhibit pH-dependent Fluorescence Lifetime Properties, Photochem Photobiology, 2013, 89 (2) pages 326–331
2012
Gustafson TP., Yan P., Newton P., Hunter DA., Achilefu S., Akers WJ., Mackinnon SE., Johnson PJ., Berezin MY. A NIR Dye for Development of Peripheral Nerve Targeted Probes, MedChemCommun, 2012 3, 685-690.
Gustafson TP., Cao Q., Achilefu S., Berezin MY. Defining a Polymethine Dye for Fluorescence Anisotropy Applications in the NIR Spectral Range, ChemPhysChem, 2012, (3):716-23.
Guo K., Achilefu, S., Berezin MY. Dating Bloodstains with Fluorescence Lifetime Measurements, Chemistry, Eur. J., 2012, 18 (5), 1303–1305.
2011
Berezin MY., Zhan C., Lee H., Joo C., Akers WJ., Yazdanfar S., Achilefu S. Two-photon optical properties of near-infrared dyes at 1.55 μm excitation. J. Phys. Chem. B. 2011, 115(39):11530-5.
Akers, W., Kim, C., Berezin, M., Guo, K., Fuhrhop, R, Lanza, G., Fischer, G., Daltrozzo, E., Zumbusch, A., Cai, X., Wang, L., Achilefu, S. Non-invasive Photoacoustic and Fluorescence Sentinel Lymph Node Identification using Dye-loaded Perfluorocarbon Nanoparticles, ACS Nano, 2011, 5(1):173-82).
Berezin M., Guo K., Akers W., Livingston J., Solomon M., Lee H., Liang K, Agee A.,. and Achilefu S., Rational Approach to Select Small Peptide Molecular Probes Labeled with Fluorescent Cyanine Labels Dyes for in vivo Optical Imaging, Biochemistry, 2011; 50(13):2691-700).
Liu Y., Bauer AQ., Akers WJ., Sudlow G., Liang K., Shen D., Berezin MY., Culver JP., Achilefu S. Hands-free, Wireless Goggles for Near-infrared Fluorescence and Real-time Image-guided Surgery, Surgery, 2011, 149(5):689-98.
Berezin M.., Guo K., Akers W., Northdurft RE., Culver JP., Teng B., Vasalatiy O., Barbacow K., Gandjbakhche A., Griffiths GL., Achilefu S. Near-Infrared Fluorescence Lifetime pH-Sensitive Probes. Biophys. J, 2011, 20; 100(8):2063-72.
Solomon, M., Liu, Y., Berezin, MY., Achilefu, S. Optical Imaging in Cancer Research: Basic Principles, Tumor Detection, and Therapeutic Monitoring, Medical Principles and Practice, 2011, 20(5):397-415
Solomon M., Guo K., Sudlow G., Berezin MY., Edwards W., Achilefu S., Akers W., Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer–based molecular probe, J. Biomed. Optics, 2011, 16(6).
2010
Sun, G., Berezin, M., Fan, J., Lee, H., Zhang, K., Achilefu, S., Wooley, K. Bright Fluorescent Nanoparticles for Developing of Potential Optical Imaging Contrast Agents, Nanoscale, 2010, 2, 548-558
Akers W., Zhang Z., Fuhrhop R., Berezin MY., Ye Y., Agee A., Guo K., Lanza G., Achilefu S. Targeting of ανβ3-Integrins Expressed on Tumor Tissue and Neovasculature Using  Fluorescent Small Molecules and Nanoparticles, Nanomedicine, 2010, 5 (5), 715-26.
Berezin MY., Achilefu S. Fluorescence Lifetime Measurements and Biological Imaging, Chem. Rev., 2010, 110 (5), 2641–2684.
Guo G., Berezin MY., Zheng J, Akers W., Lin F., Teng B., Vasalatiy O., Gandjbakhche A., Griffiths G. L., Achilefu  S. Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T(1) relaxivity for in vivo multimodal imaging. Chem. Commun. 2010, 46, 3705-3707.
Yazdanfar S., Joo C., Zhan C., Berezin MY., Akers W., Ye Y., Achilefu, S. Multiphoton microscopy of near infrared contrast agents, J. Biomed. Optics, 2010, 15, 030505.
Chen R., Parry J., Akers W., Berezin MY., El Naqal I., Achilefu S., Edwards B., Rogers B. Multimodality Imaging of Gene Transfer Using a Receptor-Based Reporter Gene, J. Nucl. Med. 2010, 51, (9) 1456-1463.
2009
Lee, H., Berezin, M., Guo, K., Kao, J., Achilefu, S. Near-infrared pH-Fluorescent Probes via Unexpected Barbituric Acid Mediated Synthesis Org. Lett. 2009 11(1), 29-32
Berezin, M., Kao, J., Achilefu, S. pH Dependent Optical Properties of Synthetic Fluorescent Imidazoles Chem. Eur. J. 2009, 15(14):3560-6.
Zhang, Z., Fan, J., Cheney, P., Berezin, M, Akers, W., Shen, D., Edwards, W., Culver, J., Achilefu, S. Activatable molecular systems using homologous near-infrared fluorescent probes for monitoring enzyme activities in vitro, in cellulo, and in vivo  Mol. Pharmaceutics. 2009 6(2) 416-27.
Goiffon, R., Akers, W., Berezin, M., Lee, H., Achilefu, S. Detecting Renal Function In Vivo with Fluorescence Lifetime Imaging J. Biomed. Optics, 2009,  14 (2), pp. 020501-3
Berezin, M, Guo, K., Teng, B., Edwards, W., Anderson, C., Vasalatiy, O., Gandjbakhche, A., Griffiths, G., Achilefu, S. Radioactivity Synchronized Fluorescence Enhancement using a Radionuclide Fluorescence-Quenched Dye J. Am. Chem. Soc. 2009, 131(26): 9198-200;. The paper has been featured in Science:  J. Yeston,  Nuclear glow, (editorial choice), 2009, 324, 1619-1621.
Berezin, M., Lee, H., Akers, W. , Guo, K., Goiffon, R.J., Almutairi, A., Fréchet, J., Achilefu, S. Engineering NIR Dyes for Fluorescent Lifetime Contrast, Conf Proc IEEE Eng Med Biol Soc. 2009;1:114-7.
Berezin, M., Akers, W., Guo, K, Fischer, G. M., Daltrozzo, E., Zumbusch, A., Achilefu, S.  Long Fluorescence Lifetime Molecular Probes Based on Near Infrared Pyrrolopyrrole Cyanine Fluorophores for in vivo imaging, Biophys. J. 2009, 97, L22-L24
2008
Zhang, Z., Berezin, M., Kao, J., d’Avignon, A., Achilefu, S. Near-Infrared Dichromic Fluorescent Carbocyanine Molecules. Angew. Chem. Int. Ed. Engl. 2008; 47(19)  3584-7
Almutairi, A., Guillaudeu, S. J., Berezin, M. Y., Achilefu, S., Frechet, J. M. Biodegradable pH-Sensing Dendritic Nanoprobes for Near-Infrared Fluorescence Lifetime and Intensity Imaging. J. Am. Chem. Soc., 2008; 130(2),  444-445.
Akers, W., Berezin, M., Lee, H., Achilefu, S. Predicting In Vivo Fluorescence Lifetime Behavior of NIR Fluorescent Contrast Agents Using In Vitro Measurements, J. Biomed. Optics, 2008, 13(5), 0540421-9.
Lee, H., Berezin, M., Henary, M., Strekowski, L. Achilefu, S. Fluorescence lifetime properties of near-infrared cyanine dyes in relation to their structures J. Photochem Photobiol. A: Chemistry. 2008, 200, 438-444.
Almutairi, A., Walter J. Akers W., Berezin M., Achilefu, S., Frechet, J.M. Monitoring the biodegradation of dendritic near infrared nanoprobes by in vivo fluorescence imaging. Mol. Pharmaceutics, 2008 5 (6) 1103-1110.
2007 and before
Berezin, M., Achilefu S. Novel synthon for incorporating 1,3-dimethyl-imidazolium group into molecular architecture. Tetrahedron Lett. 2007, 48(7) 1195-1199.
Berezin, M., Lee, H., Akers, W., Nikiforovich, G., Achilefu, S., Ratiometric Analysis of Fluorescence Lifetime for Probing Binding Sites in Albumin with Near Infrared Fluorescent Molecular Probes. Photochem. Photobiol. 2007, 83, 1-8.
Berezin, M., Lee, H. Akers, W. Achilefu, S., Near Infrared Dyes as Lifetime Solvatochromic Probes for Micropolarity Measurements of Biological Systems. Biophys. J., 2007, 93, 2892-2899.
Zhang, Z., Liang, K., Bloch, S., Berezin, M., Achilefu, S. Monomolecular Multimodal Fluorescence-Radioisotope Imaging Agents.   Bioconjug. Chem. 2005, 16(5), 1232-1239.
Berezin, M., Dzenitis, J.M., Hughes, B.M., Ho, S.V. Separation of Sterols Using Zeolites.  Phys. Chem., Chem. Phys. 2001, 3, 2184-2189.
Berezin, M., Wan, K.-T., Friedman, R. M., Orth, R. G., Raman, S. N., Ho, S. V., Ebner J. R Thiol Protected Platinum Black and Palladium Black Catalysts in Oxidation Catalysis.  J. Mol. Catal. A. Chem. 2000, 158(2), 567-576.
 
Akers Publications
(1-52)
1. Solomon M, Nothdruft RE, Akers W, Edwards WB, Liang K, Xu B, et al. Multimodal fluorescence-mediated tomography and SPECT/CT for small-animal imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013;54(4):639-46. Epub 2013/03/01. doi: 10.2967/jnumed.112.105742. PubMed PMID: 23447655.
2. Sevick-Muraca EM, Akers WJ, Joshi BP, Luker GD, Cutler CS, Marnett LJ, et al. Advancing the translation of optical imaging agents for clinical imaging. Biomedical optics express. 2013;4(1):160-70. Epub 2013/01/11. doi: 10.1364/BOE.4.000160. PubMed PMID: 23304655; PubMed Central PMCID: PMC3539189.
3. Sarder P, Yazdanfar S, Akers WJ, Tang R, Sudlow GP, Egbulefu C, et al. All-near-infrared multiphoton microscopy interrogates intact tissues at deeper imaging depths than conventional single- and two-photon near-infrared excitation microscopes. Journal of biomedical optics. 2013;18(10):106012. Epub 2013/10/24. doi: 10.1117/1.JBO.18.10.106012. PubMed PMID: 24150231; PubMed Central PMCID: PMC3805921.
4. Sarder P, Gullicksrud K, Mondal S, Sudlow GP, Achilefu S, Akers WJ. Dynamic optical projection of acquired luminescence for aiding oncologic surgery. Journal of biomedical optics. 2013;18(12):120501. Epub 2013/11/29. doi: 10.1117/1.JBO.18.12.120501. PubMed PMID: 24284472.
5. Magalotti S, Gustafson TP, Cao Q, Abendschein DR, Pierce RA, Berezin MY, et al. Evaluation of inflammatory response to acute ischemia using near-infrared fluorescent reactive oxygen sensors. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2013;15(4):423-30. Epub 2013/02/05. doi: 10.1007/s11307-013-0614-2. PubMed PMID: 23378226.
6. Liu Y, Zhao YM, Akers W, Tang ZY, Fan J, Sun HC, et al. First in-human intraoperative imaging of HCC using the fluorescence goggle system and transarterial delivery of near-infrared fluorescent imaging agent: a pilot study. Translational research : the journal of laboratory and clinical medicine. 2013;162(5):324-31. Epub 2013/06/12. doi: 10.1016/j.trsl.2013.05.002. PubMed PMID: 23747795; PubMed Central PMCID: PMC3805674.
7. Liu Y, Njuguna R, Matthews T, Akers WJ, Sudlow GP, Mondal S, et al. Near-infrared fluorescence goggle system with complementary metal-oxide-semiconductor imaging sensor and see-through display. Journal of biomedical optics. 2013;18(10):101303. Epub 2013/06/04. doi: 10.1117/1.JBO.18.10.101303. PubMed PMID: 23728180; PubMed Central PMCID: PMC3667841.
8. Liu Y, Akers WJ, Bauer AQ, Mondal S, Gullicksrud K, Sudlow GP, et al. Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging. The Analyst. 2013;138(8):2254-7. Epub 2013/03/08. doi: 10.1039/c3an00165b. PubMed PMID: 23467534; PubMed Central PMCID: PMC3650133.
9. Gustafson TP, Dergunov SA, Akers WJ, Cao Q, Magalotti S, Achilefu S, et al. Blood Triggered Rapid Release Porous Nanocapsules. RSC advances. 2013;3(16):5547-55. Epub 2013/04/23. doi: 10.1039/C3RA22693J. PubMed PMID: 23606942; PubMed Central PMCID: PMC3627417.
10. Cao Q, Zhegalova NG, Wang ST, Akers WJ, Berezin MY. Multispectral imaging in the extended near-infrared window based on endogenous chromophores. Journal of biomedical optics. 2013;18(10):101318. Epub 2013/08/13. doi: 10.1117/1.JBO.18.10.101318. PubMed PMID: 23933967; PubMed Central PMCID: PMC3739874.
11. Zhang X, Bloch S, Akers W, Achilefu S. Near-infrared molecular probes for in vivo imaging. Current protocols in cytometry / editorial board, J Paul Robinson, managing editor  [et al]. 2012;Chapter 12:Unit12 27. Epub 2012/04/04. doi: 10.1002/0471142956.cy1227s60. PubMed PMID: 22470154; PubMed Central PMCID: PMC3334312.
12. Ye Y, Akers W, Xu B, Bloch S, Odonkor C, Achilefu S. Near-infrared fluorescent divalent RGD ligand for integrin alphavbeta(3)-targeted optical imaging. Bioorganic & medicinal chemistry letters. 2012;22(17):5405-9. Epub 2012/08/09. doi: 10.1016/j.bmcl.2012.07.044. PubMed PMID: 22871580; PubMed Central PMCID: PMC3423536.
13. Xue B, Deng DW, Cao J, Liu F, Li X, Akers W, et al. Synthesis of NAC capped near infrared-emitting CdTeS alloyed quantum dots and application for in vivo early tumor imaging. Dalton Trans. 2012;41(16):4935-47. Epub 2012/03/28. doi: 10.1039/c2dt12436j. PubMed PMID: 22451225.
14. Xu M, Rettig MP, Sudlow G, Wang B, Akers WJ, Cao D, et al. Preclinical evaluation of Mab CC188 for ovarian cancer imaging. International journal of cancer Journal international du cancer. 2012;131(6):1351-9. Epub 2011/12/02. doi: 10.1002/ijc.27380. PubMed PMID: 22130973; PubMed Central PMCID: PMC3339045.
15. Tu Z, Ma Y, Tian J, Li H, Akers W, Achilefu S, et al. Estrogen receptor beta potentiates the antiproliferative effect of raloxifene and affects the cell migration and invasion in HCT-116 colon cancer cells. Journal of cancer research and clinical oncology. 2012;138(7):1091-103. Epub 2012/03/09. doi: 10.1007/s00432-011-1145-3. PubMed PMID: 22398780.
16. Tu Z, Li H, Ma Y, Tang B, Tian J, Akers W, et al. The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor beta expression. Molecular and cellular biochemistry. 2012;366(1-2):111-22. Epub 2012/04/06. doi: 10.1007/s11010-012-1288-9. PubMed PMID: 22476901.
17. Liu Y, York T, Akers W, Sudlow G, Gruev V, Achilefu S. Complementary fluorescence-polarization microscopy using division-of-focal-plane polarization imaging sensor. Journal of biomedical optics. 2012;17(11):116001. Epub 2012/11/03. doi: 10.1117/1.JBO.17.11.116001. PubMed PMID: 23117796; PubMed Central PMCID: PMC3484265.
18. Akers WJ, Xu B, Lee H, Sudlow GP, Fields GB, Achilefu S, et al. Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe. Bioconjugate chemistry. 2012;23(3):656-63. Epub 2012/02/09. doi: 10.1021/bc300027y. PubMed PMID: 22309692; PubMed Central PMCID: PMC3310325.
19. Akers WJ, Edwards WB, Kim C, Xu B, Erpelding TN, Wang LV, et al. Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography. Translational research : the journal of laboratory and clinical medicine. 2012;159(3):175-81. Epub 2012/02/22. doi: 10.1016/j.trsl.2011.09.006. PubMed PMID: 22340767; PubMed Central PMCID: PMC3286037.
20. Solomon M, White BR, Nothdruft RE, Akers W, Sudlow G, Eggebrecht AT, et al. Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging. Biomedical optics express. 2011;2(12):3267-77. Epub 2011/12/14. doi: 10.1364/BOE.2.003267. PubMed PMID: 22162817; PubMed Central PMCID: PMC3233246.
21. Solomon M, Guo K, Sudlow GP, Berezin MY, Edwards WB, Achilefu S, et al. Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe. Journal of biomedical optics. 2011;16(6):066019. Epub 2011/07/05. doi: 10.1117/1.3594153. PubMed PMID: 21721820; PubMed Central PMCID: PMC3138800.
22. Lee H, Akers W, Bhushan K, Bloch S, Sudlow G, Tang R, et al. Near-infrared pH-activatable fluorescent probes for imaging primary and metastatic breast tumors. Bioconjugate chemistry. 2011;22(4):777-84. Epub 2011/03/11. doi: 10.1021/bc100584d. PubMed PMID: 21388195; PubMed Central PMCID: PMC3080440.
23. Berezin MY, Zhan C, Lee H, Joo C, Akers WJ, Yazdanfar S, et al. Two-photon optical properties of near-infrared dyes at 1.55 mum excitation. The journal of physical chemistry B. 2011;115(39):11530-5. Epub 2011/08/27. doi: 10.1021/jp207618e. PubMed PMID: 21866928; PubMed Central PMCID: PMC3233988.
24. Berezin MY, Guo K, Akers W, Northdurft RE, Culver JP, Teng B, et al. Near-infrared fluorescence lifetime pH-sensitive probes. Biophysical journal. 2011;100(8):2063-72. Epub 2011/04/21. doi: 10.1016/j.bpj.2011.02.050. PubMed PMID: 21504743; PubMed Central PMCID: PMC3077686.
25. Berezin MY, Guo K, Akers W, Livingston J, Solomon M, Lee H, et al. Rational approach to select small peptide molecular probes labeled with fluorescent cyanine dyes for in vivo optical imaging. Biochemistry. 2011;50(13):2691-700. Epub 2011/02/19. doi: 10.1021/bi2000966. PubMed PMID: 21329363; PubMed Central PMCID: PMC3068226.
26. Akers WJ, Kim C, Berezin M, Guo K, Fuhrhop R, Lanza GM, et al. Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. ACS nano. 2011;5(1):173-82. Epub 2010/12/22. doi: 10.1021/nn102274q. PubMed PMID: 21171567; PubMed Central PMCID: PMC3026895.
27. Yazdanfar S, Joo C, Zhan C, Berezin MY, Akers WJ, Achilefu S. Multiphoton microscopy with near infrared contrast agents. Journal of biomedical optics. 2010;15(3):030505. Epub 2010/07/10. doi: 10.1117/1.3420209. PubMed PMID: 20614991; PubMed Central PMCID: PMC2881927.
28. Smith BA, Akers WJ, Leevy WM, Lampkins AJ, Xiao S, Wolter W, et al. Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc(II)-dipicolylamine probe for anionic cell surfaces. Journal of the American Chemical Society. 2010;132(1):67-9. Epub 2009/12/18. doi: 10.1021/ja908467y. PubMed PMID: 20014845; PubMed Central PMCID: PMC2805267.
29. Kim C, Erpelding TN, Maslov K, Jankovic L, Akers WJ, Song L, et al. Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes. Journal of biomedical optics. 2010;15(4):046010. Epub 2010/08/31. doi: 10.1117/1.3469829. PubMed PMID: 20799812; PubMed Central PMCID: PMC2937045.
30. Guo K, Berezin MY, Zheng J, Akers W, Lin F, Teng B, et al. Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging. Chem Commun (Camb). 2010;46(21):3705-7. Epub 2010/04/15. doi: 10.1039/c000536c. PubMed PMID: 20390151; PubMed Central PMCID: PMC2975539.
31. Chen R, Parry JJ, Akers WJ, Berezin MY, El Naqa IM, Achilefu S, et al. Multimodality imaging of gene transfer with a receptor-based reporter gene. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010;51(9):1456-63. Epub 2010/08/20. doi: 10.2967/jnumed.109.063586. PubMed PMID: 20720053; PubMed Central PMCID: PMC2981350.
32. Akers WJ, Zhang Z, Berezin M, Ye Y, Agee A, Guo K, et al. Targeting of alpha(nu)beta(3)-integrins expressed on tumor tissue and neovasculature using fluorescent small molecules and nanoparticles. Nanomedicine (Lond). 2010;5(5):715-26. Epub 2010/07/29. doi: 10.2217/nnm.10.38. PubMed PMID: 20662643; PubMed Central PMCID: PMC2914325.
33. Zhang Z, Fan J, Cheney PP, Berezin MY, Edwards WB, Akers WJ, et al. Activatable molecular systems using homologous near-infrared fluorescent probes for monitoring enzyme activities in vitro, in cellulo, and in vivo. Molecular pharmaceutics. 2009;6(2):416-27. Epub 2009/09/01. doi: 10.1021/mp800264k. PubMed PMID: 19718795; PubMed Central PMCID: PMC2913166.
34. Nothdurft RE, Patwardhan SV, Akers W, Ye Y, Achilefu S, Culver JP. In vivo fluorescence lifetime tomography. Journal of biomedical optics. 2009;14(2):024004. Epub 2009/05/02. doi: 10.1117/1.3086607. PubMed PMID: 19405734.
35. Lee H, Akers WJ, Cheney PP, Edwards WB, Liang K, Culver JP, et al. Complementary optical and nuclear imaging of caspase-3 activity using combined activatable and radio-labeled multimodality molecular probe. Journal of biomedical optics. 2009;14(4):040507. Epub 2009/09/04. doi: 10.1117/1.3207156. PubMed PMID: 19725712; PubMed Central PMCID: PMC2916017.
36. Hsu KM, Pratt JR, Akers WJ, Achilefu SI, Yokoyama WM. Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. The Journal of general virology. 2009;90(Pt 1):33-43. Epub 2008/12/18. doi: 10.1099/vir.0.006668-0. PubMed PMID: 19088270; PubMed Central PMCID: PMC2762738.
37. Goiffon RJ, Akers WJ, Berezin MY, Lee H, Achilefu S. Dynamic noninvasive monitoring of renal function in vivo by fluorescence lifetime imaging. Journal of biomedical optics. 2009;14(2):020501. Epub 2009/05/02. doi: 10.1117/1.3095800. PubMed PMID: 19405707; PubMed Central PMCID: PMC2914690.
38. Edwards WB, Akers WJ, Ye Y, Cheney PP, Bloch S, Xu B, et al. Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide. Molecular imaging. 2009;8(2):101-10. Epub 2009/04/29. PubMed PMID: 19397855; PubMed Central PMCID: PMC2975541.
39. Berezin MY, Lee H, Akers W, Guo K, Goiffon RJ, Almutairi A, et al. Engineering NIR dyes for fluorescent lifetime contrast. Conference proceedings :  Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2009;2009:114-7. Epub 2009/12/08. doi: 10.1109/IEMBS.2009.5334834. PubMed PMID: 19964923.
40. Berezin MY, Akers WJ, Guo K, Fischer GM, Daltrozzo E, Zumbusch A, et al. Long fluorescence lifetime molecular probes based on near infrared pyrrolopyrrole cyanine fluorophores for in vivo imaging. Biophysical journal. 2009;97(9):L22-4. Epub 2009/11/04. doi: 10.1016/j.bpj.2009.08.022. PubMed PMID: 19883579; PubMed Central PMCID: PMC2770609.
41. Edwards WB, Xu B, Akers W, Cheney PP, Liang K, Rogers BE, et al. Agonist-antagonist dilemma in molecular imaging: evaluation of a monomolecular multimodal imaging agent for the somatostatin receptor. Bioconjugate chemistry. 2008;19(1):192-200. Epub 2007/11/21. doi: 10.1021/bc700291m. PubMed PMID: 18020401; PubMed Central PMCID: PMC2539107.
42. Culver J, Akers W, Achilefu S. Multimodality molecular imaging with combined optical and SPECT/PET modalities. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008;49(2):169-72. Epub 2008/01/18. doi: 10.2967/jnumed.107.043331. PubMed PMID: 18199608.
43. Almutairi A, Akers WJ, Berezin MY, Achilefu S, Frechet JM. Monitoring the biodegradation of dendritic near-infrared nanoprobes by in vivo fluorescence imaging. Molecular pharmaceutics. 2008;5(6):1103-10. Epub 2009/05/13. PubMed PMID: 19434857; PubMed Central PMCID: PMC2772156.
44. Akers WJ, Berezin MY, Lee H, Achilefu S. Predicting in vivo fluorescence lifetime behavior of near-infrared fluorescent contrast agents using in vitro measurements. Journal of biomedical optics. 2008;13(5):054042. Epub 2008/11/22. doi: 10.1117/1.2982535. PubMed PMID: 19021422; PubMed Central PMCID: PMC2744956.
45. Berezin MY, Lee H, Akers W, Nikiforovich G, Achilefu S. Ratiometric analysis of fluorescence lifetime for probing binding sites in albumin with near-infrared fluorescent molecular probes. Photochemistry and photobiology. 2007;83(6):1371-8. Epub 2007/11/22. doi: 10.1111/j.1751-1097.2007.00173.x. PubMed PMID: 18028211.
46. Berezin MY, Lee H, Akers W, Achilefu S. Near infrared dyes as lifetime solvatochromic probes for micropolarity measurements of biological systems. Biophysical journal. 2007;93(8):2892-9. Epub 2007/06/19. doi: 10.1529/biophysj.107.111609. PubMed PMID: 17573433; PubMed Central PMCID: PMC1989699.
47. Akers W, Lesage F, Holten D, Achilefu S. In vivo resolution of multiexponential decays of multiple near-infrared molecular probes by fluorescence lifetime-gated whole-body time-resolved diffuse optical imaging. Molecular imaging. 2007;6(4):237-46. Epub 2007/08/23. PubMed PMID: 17711779.
48. Haidekker MA, Akers WJ, Fischer D, Theodorakis EA. Optical fiber-based fluorescent viscosity sensor. Optics letters. 2006;31(17):2529-31. Epub 2006/08/12. PubMed PMID: 16902608.
49. Akers WJ, Haidekker MA. Precision assessment of biofluid viscosity measurements using molecular rotors. Journal of biomechanical engineering. 2005;127(3):450-4. Epub 2005/08/03. PubMed PMID: 16060351.
50. Akers WJ, Cupps JM, Haidekker MA. Interaction of fluorescent molecular rotors with blood plasma proteins. Biorheology. 2005;42(5):335-44. Epub 2005/11/26. PubMed PMID: 16308465.
51. Haidekker MA, Brady TP, Chalian SH, Akers W, Lichlyter D, Theodorakis EA. Hydrophilic molecular rotor derivatives-synthesis and characterization. Bioorganic chemistry. 2004;32(4):274-89. Epub 2004/06/24. doi: 10.1016/j.bioorg.2004.04.002. PubMed PMID: 15210341.
52. Akers W, Haidekker MA. A molecular rotor as viscosity sensor in aqueous colloid solutions. Journal of biomechanical engineering. 2004;126(3):340-5. Epub 2004/09/03. PubMed PMID: 15341170.

Shokeen Publications

1. Jiang, M.; Ferdani, R.; Shokeen, M. and Anderson, C.J.  “Comparison of two cross-bridged macrocyclic chelators for the evaluation of 64Cu-labeled-LLP2A, a peptidomimetic ligand targeting VLA-4-positive tumors” Nucl Med Biol 2013, 40(2): 245-51. PMID: 23265977
2. Beaino, W.; Schwarz, J. K.; Zahner, M.; Zheleznyak, A.; Shokeen, M.; Jiang, M.; Anderson, C. J., “Molecular imaging of the premetastatic niche in the lungs of a metastatic mouse model of breast cancer” Journal of Nuclear Medicine (JNM) 2013, 54 (Suppl. 1): 3-4. ISSN: 0161-5505
3. Soodgupta, D.; Hurchla, M. A.; Jiang, M.; Zheleznyak, A.; Weilbaecher, K. N.; Anderson, C. J.; Tomasson, M. H.*; Shokeen, M.*, “Very late antigen-4 (alpha(4)beta(1) Integrin) targeted PET imaging of multiple myeloma” PLoS One 2013, 8(2): e5584. PMID: 23409060 (*Corresponding author)
4. Shokeen, M.; Zheleznyak, M.; Wilson, J. M.; Jiang, M.; Liu, R.; Ferdani, R.; Lam, K.; Schwarz, JK; Anderson, C. J., “Molecular Imaging of Very Late Antigen-4 (α4β1 integrin) in the Pre-Metastatic Niche.” Journal of Nuclear Medicine (JNM) 2012, 53(2): 779-86. PMID: 22496586
5. Shokeen, M.; Pressly, E.; Connal, L.; Liu, Y.; Hawker, C.J.; Woodard, PK; Anderson, C.J.; Achilefu, S.; Welch, M.J., “Multi-modal in cellulo evaluation of NPR-C targeted C-ANF-peptide and C-ANF-comb nanoparticles.” Proceedings of SPIE 2012, 8233 (1).
6. Shokeen, M. and Wadas, T.J., “The Development of Copper Radiopharmaceuticals for Imaging and Therapy.” Medicinal Chemistry 2011; 7(5):413-29. PMID: 21711219
7. Shokeen, M.; Pressly, E.; Hagooly, A.;Zheleznyak, A.; Ramos, N.; Welch, M. J.; Hawker, C. J.; Anderson, C. J., “Evaluation of multivalent, functional polymeric nanoparticles for imaging applications.” ACSnano 2011, 5(2), 738-47. PMID: 21275414
8. Anderson, C.J.; Bulte, J.W.; Chen, K.; Chen, X.; Khaw, B.A.; Shokeen, M.; Wooley, K.L.; Vanbrocklin, H.F., “Design of Targeted Cardiovascular Molecular Imaging Probes.” Journal of Nuclear Medicine (JNM) 2010, April 15, 51, 1S-15S.PMID: 20395345
9. Shokeen, M.; Anderson, C. J., "Molecular Imaging of Cancer with Copper-64 Radiopharmaceuticals and Positron Emission Tomography (PET)."Accounts of Chemical Research 2009, 42(7), 832-41. PMID: 19530674
10. Almutairi, A.; Rossin, R.; Shokeen, M.; Hagooly, A.; Ananth, A.; Capoccia, B.; Guillaudeu, S.; Abendschein, D.; Anderson, C. J.; Welch, M. J.; Fréchet, J. M. J., “Biodegradable dendridic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis.” Proceedings of the National Academy of Sciences 2009, 106(3), 685-690. PMID: 19129498
11. Shokeen, M.; Fettig, N. M.; Rossin, R., “Synthesis, in vitro and in vivo evaluation of radiolabeled nanoparticles.” The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2008, 52(3), 267-77. PMID: 18475250
12. Hagooly, A.; Almutairi, A.; Rossin, R.; Shokeen, M.; Hagooly, A.; Ananth, A.; Abendschein, D.; Anderson, C. J.; Fréchet, J. M. J.; Welch, M. J., “Evaluation of a RGD-dendrimer labeled with 76Br in hindlimb ischemia mouse model.” Journal of Nuclear Medicine 2008; 49 (Supplement 1):184P.
13. Shokeen, M.; Schwarz, JK, Zheleznyak, M.; Wilson, J. M.; Nguyen, K.; Liu, R.; Collins, L.; Ferdani, R.; Piwnica-Worms, D.; Lam, K., Anderson, C. J., “Imaging Sites of Metastasis Before They Happen: Targeting the Premetastatic Niche.” Journal of Women’s Health 2009, 18(10), 1494.
14. Bleeke, J. R.; Shokeen, M.; Wise, E. S.; Rath, N. P.,“Pentadienyl-Metal-Phosphine Chemistry. 33. Thiapentadienyl-Rhodium-Phosphine Chemistry.”  Organometallics 2006, 25 (10), 2486-2500.
15. Bleeke, J. R.; Wise, E. S.; Shokeen, M.; Rath, N. P.,“Synthesis, Structure, and Spectroscopy of (Thiapentadienyl)rhodium Phosphine Complexes.”  Organometallics 2005, 24, 805-808.
16. Bleeke, J. R.; Hinkle, P. V.; Shokeen, M.; Rath, N. P., “Metallacyclohexadiene and Metallabenzene Chemistry. Part 18. Synthesis, Structure, Spectroscopy, and Reactivity of a Neutral Iridathiabenzene.” Organometallics 2004, 23, 4139-4149.