Optical Radiology Laboratory (ORL)

Julie Prior

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8225
4525 Scott Avenue
St. Louis, MO 63110
(314) 362-9357

Current Position
Research Lab Supervisor

Research Interests
Small animal imaging, including bioluminescence, fluorescence, SPECT and PET, as a means to study molecular events in the context of cancer and other diseases, as well as for the evaluation of new therapeutics and imaging agents.

Selected Publications

  • Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD. The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol 2013, 15:677-87.
  • Chinault SL, Prior JL, Kaltenbronn KM, Penly A, Weilbaecher KN, Piwnica-Worms D, Blumer KJ. Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. Clin Cancer Res 2012, 18:4136-44.
  • Pazolli E, Alspach E, Milczarek A, Prior J, Piwnica-Worms D, Stewart SA. Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res 2012, 72:2251-61.
  • Choi J, Ritchey J, Prior JL, Holt M, Shannon WD, Deych E, Piwnica-Worms DR, DiPersio JF. In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia. Blood, 2010, 116:129-39.
  • Pichler A, Prior JL, Luker GD, Piwnica-Worms D. Generation of a highly inducible Gal4-->Fluc universal reporter mouse for in vivo bioluminescence imaging. Proc Natl Acad Sci U S A 2008, 105:15932-7.
  • Harpstrite SE, Prior JL, Rath NP, Sharma V. Metalloprobes: synthesis, characterization, potency of a novel gallium(III) complex in human epidermal carcinoma cells. J Inorg Biochem 2007, 101:1347-53.