MIR Research Laboratories

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Optical Radiology Laboratory (ORL)

Joseph Ippolito

Contact Information
Washington University School of Medicine
Department of Radiology
Campus Box 8131
660 S.Euclid Ave
St. Louis, MO 63110
(314) 362-2978

Current Position

Research Interests
Cancer metabolism with an emphasis on castrate resistant prostate cancer and neuroendocrine cancers, metabolic imaging with PET, MRI, and optical imaging, metabolism-directed cancer therapeutics..

Key Publications:
1. Ulrich H, Ippolito JE, Pagán OR, Eterović VA, Hann RM, Shi H, Lis JT, Eldefrawi ME, Hess GP. In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci. USA. 1998; 95(24):14051-6. PMID: 9826651. PMCID: PMC24324.
2. Hess GP, Ulrich H, Breitinger HG, Niu L, Gameiro AM, Grewer C, Srivastava S, Ippolito JE, Lee SM, Jayaraman V, Coombs SE. Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801. Proc Natl Acad Sci U S A. 2000; 97(25):13895-900. PMID: 11095713. PMCID: PMC17672.
3. Ippolito JE, Hu Y, Garabedian EM, Humphrey PA, Gordon JI. Molecular characterization of a metastatic neuroendocrine cell cancer arising in the prostates of transgenic mice. J. Biol. Chem. 2002; 277(46):44462-44474. PMID: 12228243.
4. Syder AJ, Karam SM, Mills JC, Ippolito JE, Ansari HR, Farook V, Gordon JI. A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype. Proc. Natl. Acad. Sci. USA. 2004; 101(13):4471-4476. PMID: 15070742; PMCID: PMC384771.
5. Ippolito JE, Xu J, Jain S, Moulder K, Mennerick S, Crowley JR, Townsend RR, Gordon JI. An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers. Proc. Natl. Acad. Sci. USA. 2005; 102(28):9901-9906. PMID: 15998737; PMCID: PMC1169236.
6. Giannakis M, Stappenbeck TS, Mills JC, Leip DG, Lovett M, Clifton SW, Ippolito JE, Glasscock JI, Arumugam M, Brent MR, Gordon JI. Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches. J. Biol. Chem. 2006; 281(16):11292-11300. PMID: 16464855.
Ippolito, J
7. Ippolito JE, Merritt ME, Bäckhed F, Moulder KL, Mennerick S, Manchester JK, Gammon ST, Piwnica-Worms D, Gordon JI. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc. Natl. Acad. Sci. USA. 2006; 103(33):12505-12510. PMID: 16895983; PMCID: PMC1533883.
8. Ippolito JE. Current concepts in neuroendocrine cancer metabolism. Pituitary. 2006;9(3):193-202. PMID: 17001465.
9. Ippolito JE, Piwnica-Worms D. A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. PLoS One. 2014 Feb 13;9(2):e88667. PMID: 24551133; PMCID: PMC3923810.
10. Elhammali A, Ippolito JE, Collins L, Crowley J, Marasa J, Piwnica-Worms D. A High-Throughput Fluorimetric Assay for 2-hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor. Cancer Discov. 2014 Apr 16. [Epub ahead of print] PMID: 24740997