Adam T. Eggebrecht
Contact Information
Washington University School of Medicine
Department of Radiology
4515 McKinley Ave, Room 2315
Office number: 314-747-8290
Ph.D. Physics, Washington University in St. Louis
M.A. Physics, Washington University in St. Louis
B.A. Physics, Washington University in St. Louis
Research Interests
The Neurophotonics Lab of the Optical Radiology Labs is a diverse
and interdisciplinary team whose research focuses on developing novel tools
that extend mapping of brain function beyond current limitations. We harness
the power of diffuse optics to create portable and wearable systems for
unconstrained imaging of brain function including in subjects with implanted
devices who are not able to be studied with MRI due to safety concerns. Our
currently funded efforts are focused on three broad areas: hardware
development, software and algorithm development, and applications from basic
science to clinical care. Hardware development projects concentrate on
optimizing signal-to-noise, image quality, subject comfort, and portability.
Software and algorithm projects include Finite Element Modeling of light
propagation, image reconstruction speed and accuracy, spatial registration of
multiple data types, and development of a self-contained toolbox, NeuroDOT, for
acquisition and analysis of diffuse optical tomography data. To further understanding
of brain function in health and disease, our lab is focused on basic science
and clinical applications including autism spectrum disorder, Parkinson's
disease, bedside imaging in the Intensive Care Unit, language processing, and
brain plasticity from childhood development throughout the lifespan. Our lab is
also developing new analytical strategies for uncovering neurophysiological
mechanisms that subserve behavior throughout the lifespan.
Key Publications:
1. Bergonzi KM, Burns-Yocum T, Bumstead J, Buckley E, Mannion P, Tracy C, Mennerick E, Ferradal S, Dehghani H, Eggebrecht AT, Culver JP. "Lightweight sCMOS-based High-Density Diffuse Optical Tomography." Neurophotonics. 5(3), 035006. doi: 10.1117/1.NPh.5.3.035006. 2018. PMID: 30137925. PMCID: PMC6096280.
2. Wheelock M.D., Austin N.C., Bora S., Eggebrecht A.T., Melzer T.R., Woodward L.J., and Smyser C.D. “Altered functional network connectivity relates to motor development in children born very preterm.” Neuroimage. S1053-8119 (18) 30749-3. doi: 10.1016/j.neuroimage.2018.08.051. 2018. PMID: 30144569.
3. Doulgerakis M, Eggebrecht AT, Wojtkiewicz S, Culver JP, Dehghani H. ‘Towards real time diffuse optical tomography: Accelerating light propagation modeling employing parallel computing on GPU and CPU.’ J. Biomedical Optics. 12, 1-11. 2017. doi:
10.1117/1.JBO.22.12.125001. PMID: 29197176. PMCID: PMC5709934.
4. Marrus N, Eggebrecht AT, Todorov A, Elison JT, Wolff JJ, Cole L, Gao W, Pandey J, Shen MD, Swanson MR, Emerson R, Klohr CL, Adams CM, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Constantino JN, Evans AC, Hazlett HC, Dager S, Paterson SJ, Schultz RT, Styner M, Gerig G, The IBIS Network, Schlaggar BL, Piven J, and Pruett JR, ‘Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers,’ Cerebral Cortex, 28. 750-763. 2017. doi: 10.1093/cercor/bhx313. 2017. PMID: 29186388.
5. Hassanpour MS, Eggebrecht AT, Culver JP, Peelle JE, ‘Mapping effective connectivity within cortical networks with diffuse optical tomography.’ Neurophotonics, 4(4). 2017. doi: 10.1117/1.Nph.4.4.041402. PMID: 28744475. PMCID: PMC5521306.
6. Eggebrecht AT, Elison J.T., Feczko E., Todorov A., Wolff J.J., Kandala S., Adams C.M., Snyder A.Z., Lewis J.D., Estes A.M., Zwaigenbaum L., Botteron K.N., McKinstry R.C., Constantino J.N., Evans A., Hazlett H.C., Dager S., Paterson S.J., Schultz R.T., Styner M.A., Gerig G., Das S., Kostopoulos P., The IBIS Network, Schlaggar B.L., Petersen S.E., Piven J., Pruett, Jr. J.R. ‘Joint attention and brain functional connectivity in infants and toddlers.’, Cerebral Cortex 27 (3), 1709-1720. 2017. doi: 10.1093/cercor/bhw403. PMID: 28062515. PMCID: PMC5452276.
7. Ferradal SL, Liao SM, Eggebrecht AT, Shimony JS, Inder TE, Culver JP, Smyser CD, ‘Functional imaging of the developing brain at the bedside using diffuse optical tomography.’ Cerebral Cortex pii: bhu320. 2015. PMID: 25595183. PMCID: PMC4785947.
8. Eggebrecht AT, Ferradal SL, Viehoever AR, Hassanpour MS, Dehghani H, Snyder AZ, Hershey T, Culver, JP, ‘Mapping distributed brain function and networks with diffuse optical tomography.’ Nature Photonics 8. 448-454. 2014. PMID: 25083161. PMCID: PMC4114252.
9. Eggebrecht AT, White BR, Ferradal SL, Chen C, Zhan Y, Snyder AZ, Dehghani H, Culver JP, ‘A Quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping.’ Neuroimage 61(4):1120-8. 2012. PMID: 22330315. PMCID: PMC3581336.
Complete list of published articles