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Optical Radiology Laboratory (ORL)

Adam T. Eggebrecht

Contact Information
Washington University School of Medicine
Department of Radiology
4515 McKinley Ave, Room 2315
St. Louis, MO 63110
(314) 747-8290
aeggebre@wustl.edu

Current Position
Instructor

Education
Ph.D. Physics, Washington University in St. Louis
M.A. Physics, Washington University in St. Louis
B.A. Physics, Washington University in St. Louis

Research Interests
The Neurophotonics Lab of the Optical Radiology Labs is a diverse and interdisciplinary team whose research focuses on developing novel tools that extend mapping of brain function beyond current limitations. We harness the power of diffuse optics to create portable and wearable systems for unconstrained imaging of brain function including in subjects with implanted devices who are not able to be studied with MRI due to safety concerns. Our efforts are focused on three broad areas: hardware development, software and algorithm development, and applications from basic science to clinical care. Hardware development projects concentrate on optimizing signal-to-noise, image quality, subject comfort, and portability. Software and algorithm projects include Finite Element Modeling of light propagation, image reconstruction speed and accuracy, spatial registration of multiple data types, and development of a self-contained toolbox, NeuroDOT, for acquisition and analysis of diffuse optical tomography data. To further understanding of brain function in health and disease, our lab is focused on basic science and clinical applications including autism spectrum disorder, Parkinson's disease, bedside imaging in the Intensive Care Unit, language processing, and brain plasticity from childhood development throughout the lifespan.

Key Publications:
1. Eggebrecht AT, White BR, Ferradal SL, Chen C, Zhan Y, Snyder AZ, Dehghani H, Culver JP, "A Quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping." Neuroimage 61(4):1120-8. 2012. PMID: 22330315.

2. Zhan Y, Eggebrecht AT, Culver JP, Dehghani H, "Image quality analysis of high density diffuse optical tomography incorporating a subject-specific head model." Frontiers in Neuroenergetics 4. 1-9. 2012. PMID: 22654754.

3. Ferradal SL, Eggebrecht AT, Hassanpour M, Snyder AZ, Culver JP, “Atlas-based high-density diffuse optical tomography: in vivo validation against functional MRI.” Neuroimage 85, Part 1: 117-126. 2014. PMID: 23578579

4. Hassanpour MS, White BR, Eggebrecht AT, Ferradal SL, Snyder AZ, Culver JP, “Statistical analysis of high density diffuse optical tomography”, NeuroImage, Volume 85, Part 1: 104–116. 2014. PMID: 23732886.

5. Eggebrecht AT, Ferradal SL, Viehoever AR, Hassanpour MS, Dehghani H, Snyder AZ, Hershey T, Culver, JP, “Mapping distributed brain function and networks with diffuse optical tomography.” Nature Photonics 8. 448-454. 2014. PMID: 25083161.

6. Wu X, Eggebrecht AT, Ferradal SL, Culver JP, Dehghani H, “Quantitative evaluation of atlas-based high-density diffuse optical tomography for imaging of the human visual cortex.” J. Biomedical Optics Express (11), 3882-3900, 2014. PMID: 25426318.

7. Ferradal SL, Liao SM, Eggebrecht AT, Shimony JS, Inder TE, Culver JP, Smyser CD, “Functional imaging of the developing brain at the bedside using diffuse optical tomography.” Cerebral Cortex pii: bhu320. 2015. PMID: 25595183.

8. Hassanpour MS, Eggebrecht AT, Culver JP, Peelle JE, “Mapping cortical responses to speech using high-density diffuse optical tomography.” Neuroimage 117. 319-326. 2015. PMID: 26026816.

9. Wu X, Eggebrecht AT, Ferradal SL, Culver JP, Dehghani H, “Evaluation of rigid registration methods for whole head imaging in diffuse optical tomography.” Neurophotonics (in press), 2015. PMID: pending.

Complete list of published articles:
http://www.ncbi.nlm.nih.gov/pubmed/?term=eggebrecht+at