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Optical Radiology Laboratory (ORL)

Adam T. Eggebrecht

Contact Information
Washington University School of Medicine
Department of Radiology
4515 McKinley Ave, Room 2315

Office number: 314-747-8290
Ph.D. Physics, Washington University in St. Louis
M.A. Physics, Washington University in St. Louis
B.A. Physics, Washington University in St. Louis

Research Interests
The Neurophotonics Lab of the Optical Radiology Labs is a diverse and interdisciplinary team whose research focuses on developing novel tools that extend mapping of brain function beyond current limitations. We harness the power of diffuse optics to create portable and wearable systems for unconstrained imaging of brain function including in subjects with implanted devices who are not able to be studied with MRI due to safety concerns. Our currently funded efforts are focused on three broad areas: hardware development, software and algorithm development, and applications from basic science to clinical care. Hardware development projects concentrate on optimizing signal-to-noise, image quality, subject comfort, and portability. Software and algorithm projects include Finite Element Modeling of light propagation, image reconstruction speed and accuracy, spatial registration of multiple data types, and development of a self-contained toolbox, NeuroDOT, for acquisition and analysis of diffuse optical tomography data. To further understanding of brain function in health and disease, our lab is focused on basic science and clinical applications including autism spectrum disorder, Parkinson's disease, bedside imaging in the Intensive Care Unit, language processing, and brain plasticity from childhood development throughout the lifespan. Our lab is also developing new analytical strategies for uncovering neurophysiological mechanisms that subserve behavior throughout the lifespan.

Key Publications:

1. Bergonzi KM, Burns-Yocum T, Bumstead J, Buckley E, Mannion P, Tracy C, Mennerick E, Ferradal S, Dehghani H, Eggebrecht AT, Culver JP. "Lightweight sCMOS-based High-Density Diffuse Optical Tomography." Neurophotonics. 5(3), 035006. doi: 10.1117/1.NPh.5.3.035006. 2018. PMID: 30137925. PMCID: PMC6096280.

2. Wheelock M.D., Austin N.C., Bora S., Eggebrecht A.T., Melzer T.R., Woodward L.J., and Smyser C.D. “Altered functional network connectivity relates to motor development in children born very preterm.” Neuroimage. S1053-8119 (18) 30749-3. doi: 10.1016/j.neuroimage.2018.08.051. 2018. PMID: 30144569.

3. Doulgerakis M, Eggebrecht AT, Wojtkiewicz S, Culver JP, Dehghani H. ‘Towards real time diffuse optical tomography: Accelerating light propagation modeling employing parallel computing on GPU and CPU.’ J. Biomedical Optics. 12, 1-11. 2017. doi:

10.1117/1.JBO.22.12.125001. PMID: 29197176. PMCID: PMC5709934.

4. Marrus N, Eggebrecht AT, Todorov A, Elison JT, Wolff JJ, Cole L, Gao W, Pandey J, Shen MD, Swanson MR, Emerson R, Klohr CL, Adams CM, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Constantino JN, Evans AC, Hazlett HC, Dager S, Paterson SJ, Schultz RT, Styner M, Gerig G, The IBIS Network, Schlaggar BL, Piven J, and Pruett JR, ‘Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers,’ Cerebral Cortex, 28. 750-763. 2017. doi: 10.1093/cercor/bhx313. 2017. PMID: 29186388.

5. Hassanpour MS, Eggebrecht AT, Culver JP, Peelle JE, ‘Mapping effective connectivity within cortical networks with diffuse optical tomography.’ Neurophotonics, 4(4). 2017. doi: 10.1117/1.Nph.4.4.041402. PMID: 28744475. PMCID: PMC5521306.

6. Eggebrecht AT, Elison J.T., Feczko E., Todorov A., Wolff J.J., Kandala S., Adams C.M., Snyder A.Z., Lewis J.D., Estes A.M., Zwaigenbaum L., Botteron K.N., McKinstry R.C., Constantino J.N., Evans A., Hazlett H.C., Dager S., Paterson S.J., Schultz R.T., Styner M.A., Gerig G., Das S., Kostopoulos P., The IBIS Network, Schlaggar B.L., Petersen S.E., Piven J., Pruett, Jr. J.R. ‘Joint attention and brain functional connectivity in infants and toddlers.’, Cerebral Cortex 27 (3), 1709-1720. 2017. doi: 10.1093/cercor/bhw403. PMID: 28062515. PMCID: PMC5452276.

7. Ferradal SL, Liao SM, Eggebrecht AT, Shimony JS, Inder TE, Culver JP, Smyser CD, ‘Functional imaging of the developing brain at the bedside using diffuse optical tomography.’ Cerebral Cortex pii: bhu320. 2015. PMID: 25595183. PMCID: PMC4785947.

8. Eggebrecht AT, Ferradal SL, Viehoever AR, Hassanpour MS, Dehghani H, Snyder AZ, Hershey T, Culver, JP, ‘Mapping distributed brain function and networks with diffuse optical tomography.’ Nature Photonics 8. 448-454. 2014. PMID: 25083161. PMCID: PMC4114252.

9. Eggebrecht AT, White BR, Ferradal SL, Chen C, Zhan Y, Snyder AZ, Dehghani H, Culver JP, ‘A Quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping.’ Neuroimage 61(4):1120-8. 2012. PMID: 22330315. PMCID: PMC3581336.

Complete list of published articles