MIR Research Laboratories

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Samuel Achilefu, PhD

Contact Information
Washington University School of Medicine
Malllinckrodt Institute of Radiology
Department of Radiology,
4525 Scott Avenue, St. Louis, MO 63110
Phone: 314-362-8599
E-mail: achilefus@mir.wustl.edu

Current Position
Professor of Radiology, Biochemistry and Molecular Biophysics, & Biomedical Engineering
Chief, Optical Radiology Laboratory
Director, Molecular Imaging Center
Co-Leader, Oncologic Imaging Program of the NCI-designated Siteman Cancer Center of Excellence
Michel M. Ter-Pogossian Endowed Chair in Radiology

Research Interests
Our research interests are in the design, development, and biochemical evaluation of molecular imaging agents and drugs in cells and living organisms.Through highly multidisciplinary research, we also develop new imaging systems for clinical applications. Our most recent accomplishments include the discovery of a broad spectrum cancer imaging agent, a portable goggle device for image-guided surgery, a depth-independent photo therapeutic platform for treating diseases and a reporter molecular system for reporting kinase activities. The ultimate goal is to validate new research concepts in the lab and translate them to humans.

Publications  (Chronological order) for additional publications access PubMED

  1. Ippolito JE, Brandenburg MW, Ge X, Crowley JR, Kirmess KM, Som A, D'Avignon DA, Arbeit JM, Achilefu S, Yarasheski KE, Milbrandt J. Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide. PloS one. 2016;11(7):e0159675. doi: 10.1371/journal.pone.0159675. PubMed PMID: 27438712; PubMed Central PMCID: PMC4954648.
  2. Liu Z, Achilefu S. Editorial: Nanoscale approaches for cancer diagnosis and treatment. Nanoscale. 2016;8(25):12391-3. doi: 10.1039/c6nr90111e. PubMed PMID: 27304229.
  3. Som A, Bloch S, Ippolito JE, Achilefu S. Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo. Scientific reports. 2016;6:27803. doi: 10.1038/srep27803. PubMed PMID: 27302093; PubMed Central PMCID: PMC4908587.
  4. McKenzie M, Betts D, Suh A, Bui K, Tang R, Liang K, Achilefu S, Kwon GS, Cho H. Proof-of-Concept of Polymeric Sol-Gels in Multi-Drug Delivery and Intraoperative Image-Guided Surgery for Peritoneal Ovarian Cancer. Pharmaceutical research. 2016;33(9):2298-306. doi: 10.1007/s11095-016-1968-3. PubMed PMID: 27283829.
  5. Miller JP, Egbulefu C, Prior JL, Zhou M, Achilefu S. Gradient-Based Algorithm for Determining Tumor Volumes in Small Animals Using Planar Fluorescence Imaging Platform. Tomography : a journal for imaging research. 2016;2(1):17-25. doi: 10.18383/j.tom.2016.00100. PubMed PMID: 27200417; PubMed Central PMCID: PMC4869719.
  6. Molligan J, Mitchell R, Schon L, Achilefu S, Zahoor T, Cho Y, Loube J, Zhang Z. Influence of Bone and Muscle Injuries on the Osteogenic Potential of Muscle Progenitors: Contribution of Tissue Environment to Heterotopic Ossification. Stem cells translational medicine. 2016;5(6):745-53. doi: 10.5966/sctm.2015-0082. PubMed PMID: 27112178; PubMed Central PMCID: PMC4878324.
  7. de la Puente P, Quan N, Hoo RS, Muz B, Gilson RC, Luderer M, King J, Achilefu S, Salama NN, Vij R, Azab AK. Newly established myeloma-derived stromal cell line MSP-1 supports multiple myeloma proliferation, migration, and adhesion and induces drug resistance more than normal-derived stroma. Haematologica. 2016;101(7):e307-11. doi: 10.3324/haematol.2016.142190. PubMed PMID: 27081175.
  8. Tsen SD, Kibler K, Jacobs B, Fay JC, Podolnikova NP, Ugarova TP, Achilefu S, Tsen KT. Selective photonic disinfection of cell culture using a visible ultrashort pulsed laser. IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society. 2016;22(3). doi: 10.1109/JSTQE.2015.2498920. PubMed PMID: 27013847; PubMed Central PMCID: PMC4800335.
  9. Som A, Raliya R, Tian L, Akers W, Ippolito JE, Singamaneni S, Biswas P, Achilefu S. Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo. Nanoscale. 2016;8(25):12639-47. doi: 10.1039/c5nr06162h. PubMed PMID: 26745389; PubMed Central PMCID: PMC4919221.
  10. N. Kotagiri, Z. Li, X. Xu, S. Mondal, A. Nehorai, S. Achilefu: Antibody quantum dot conjugates developed via copper free click chemistry for rapid analysis of biological samples using a microfluidic microsphere array system. Bioconjugate Chem  dx.doi.org/10.1021/bc500139u (2014)
  11. Z. Tu, Y. Ma, W. Akers, S. Achilefu, Y. Gu:  Therapeutic effect of the treatment for colorectal cancer with adenoviral vectors mediated estrogen receptor β gene therapy combined with thermotherapy. J Cancer Res Clin Oncol 140   623-632 (2014)
  12. S.W. Tsen, D.H. Kingsley, C. Poweleit, S. Achilefu, D.S. Soroka, T. WU, K.T. Tsen: Studies of inactivation mechanism of non-enveloped icosahedral virus by a visible ultrashort pulsed laser. Virol  J 11  1-9 (2014)
  13. D. Hu, P. Sarder, P. Ronhovde, S. Orthaus, S. Achilefu, Z. Nussinov:  Automatic segmentation of fluorescence lifetime microscopy images of cells using multiresolution community detection-a first study.  J  Microsc 253 54-64 (2014)
  14. N. Gandra, C. Portz, L. Tian, R. Tang, B. Xu, S. Achilefu, S. Singamaneni: Probing distance-dependent plasmon-enhanced near-infrared fluorescence using polyelectrolyte multilayers as dielectric spacers. Angew Chem Int Ed Engl 53 866-870 (2014)
  15. X. Li, D. Deng, J. Xue, L. Qu, S. Achilefu, Y. Gu: Quantum dots based molecular beacons for in vitro and in vivo detection of MMP-2 on tumor. Biosens Bioelectron 61 5120519 (2014)
  16. Y. Pu, R. Tang, J. Xue, W.B. Wang, B. Xu, S. Achilefu: Synthesis of dye conjugates to visualize the cancer cells using fluorescence microcopy. Applied Optics 53 2345-2351 (2014)
  17. S. Palantavida, R. Tang, G.P. Sudlow, W.J. Akers, S. Achilefu, I. Sokolov: Ultrabright NIR fluorescent mesoporous silica nanoparticles.  J. Mater. Chem. B 2 3107-3114 (2014)
  18. H. Chen, X. Chi, B. Li, M. Zhang, Y. Ma, S. Achilefu, Y. Gu: Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy. Biomater Sci 2 996-1006 (2014)