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Benzinger Research Group

Research Projects

Imaging tauopathy using T807 Positron Emission Tomography (PET)
Tau pathology, consisting of neurofibrillary tangles (NFTs) is a late hallmark of multiple neurodegenerative diseases.  We are studying T807 PET in symptomatic and preclinical (pre-symptomatic) Alzheimer’s disease (AD), autosomal dominant inherited AD, frontotemporal dementia (FTD), and amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease).


Knight ADRC Research Imaging Program
The Adult Children's Study (ACS)

  • NIH/NIA AG026276
  • This is a longitudinal study of aging, beginning at age 45. Imaging includes MRI, amyloid PIB-PET, and tau T807 PET.

Collaborators Andrei Vlassenko and Marc Raichle are also performing [15]O and FDG metabolic PET in this cohort; David Balota is performing task functional MRI.

For more information.


Healthy Aging and Senile Dementia (HASD)

  • NIH/NIA AG003991 and Avid Radiopharmaceuticals, a wholly owned subsidiary of Eli Lilly
  • This is a longitudinal study of aging, beginning at age 65. Imaging includes MRI, amyloid AV45-PET, and tau T807 PET.

For more information.

Knight Alzheimer's Disease Research Center (ADRC)
International collaborations
Dominantly Inherited Alzheimer Network (DIAN) Imaging Core Lab

  • NIH/NIA 2UF1AG032438
  • This is an international study of families with autosomal dominant Alzheimer’s Diseases (AD).  Imaging includes MRI, amyloid PIB and AV45 PET, and tau T807 PET.

For more information.

Dominantly Inherited Alzheimer Network (DIAN-TU) Imaging Core Lab

  • NIA/NINDA 5U01Ag042791-02 Phase II
  • NIH/NIA 1R01AG046179 Phase III
  • This is an international study of families with autosomal dominant AD. Imaging includes MRI, amyloid PIB and AV45 PET, and tau T807 PET.

For more information.

Closed to enrollment

  • Pediatric white matter trials
  • Brain tumor imaging studies