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Electronic Radiology Laboratory (ERL)

As part of our imaging informatics activities, we are actively engaged in and offer a set of services to support multi-center clinical trials. Current trials include:

  • ECP Registry.The purposes of this prospective cohort Extracorporeal Photopheresis (ECP) Registry study are to determine the efficacy and tolerability of ECP for the treatment of progressive BOS after lung transplantation in a large patient series.  In compliance with the Centers for Medicare and Medicaid Services’ (CMS) Coverage with Evidence Development (CED) decision, the study will collect specified demographic, comorbidity, treatment, and outcome data exclusively for Medicare beneficiaries treated with ECP for Bronchiolitis Obliterans Syndrome (BOS).  ERL in conjunction with Interventional Radiology acting as an Academic Research Organization (ARO) is supporting this study.  ERL is responsible for creating and managing the study website and electronic case report forms (CRFs) to be completed by the medical institution participating in the study.  ERL will perform CRF data entry validation and assist in training the sites to use the study website along with the CRFs.
    • Principal Investigator: George Depotis, MD
    • Clinical Coordinating Center: Suresh Vedantham, MD
    • Grant: Industry Contract, Therakos, Inc (PI: Despotis),  ERL role:  Data Coordinating Center
       
  • LVIS. The Low-profile Visualized Intraluminal Support (LVIS) study purpose is to evaluate the safety and efficacy of the LVIS Device when used to facilitate endovascular coiling of wide-neck intracranial aneurysms.  ERL is responsible for receiving, removing Protected Health Information and archival of radiological imaging data to a dedicated research picture-archiving and communication system (PACS) for storage.  ERL notifies the radiologist to read the x-ray angiography images and ERL submits the radiologist’s electronic case report form data to MicroVention, Inc.
  • IRAC. The Imaging and Response Assessment Core (IRAC) is a shared resource available to Siteman Cancer Center members. IRAC provides analysis and quality control for conventional imaging studies used in response evaluation for cancer clinical trials. ERL provides transfer of radiological imaging data to a dedicated research picture-archiving and communication system (PACS) for processing and storage of images (including measurement details). All measurement results are reviewed by board-certified radiologists.  IRAC is a part of the Center for Clinical Imaging Research. 
  • SAMMPRIS.The purpose of the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) study is to evaluate treatments for preventing stroke in patients with narrowed brain blood vessels. ERL is responsible for receiving, removing Protected Health Information and archival of radiological imaging data to a dedicated research picture-archiving and communication system (PACS) for storage.
  • DIAN TU.The Dominantly Inherited Alzheimer Network Trial (DIAN TU) is an international study to assess the safety, tolerability, and biomarker efficacy of the drugs gantenerumab and solanexumab in individuals who have a genetic mutation for autosomal-dominant Alzheimer’s disease.  All imaging sessions done for the DIAN TU are stored in the DIAN Central Archive (DCA).  ERL working with the Neuroinformatics Research Group (NRG) insures all appropriate users are trained and certified to use the DCA.