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Cardiovascular Imaging Laboratory (CVIL)

Jie Zheng, Ph.D.

Current Position

Associate Professor of Radiology

 

Contact Information

Washington University School of Medicine
Department of Radiology
Campus Box 8225
4525 Scott Avenue
St. Louis, MO 63110
(314) 747-4608
zhengj@mir.wustl.edu

 

Research Interests

Quantitative myocardial functional imaging (perfusion and oxygenation) and coronary artery imaging. Non-invasive imaging of atherosclerotic plaques and associated with quantitative measurements of stress and strain. Skeletal muscle perfusion and oxygenation imaging in lower extremities in patients with diabetes and aging subjects.

 

Education

B.S. Electrical Engineering, Beijing University, PR China
Ph.D. Medical Physics, University of Cincinnati, Ohio

 

Honors/Awards

  • 1997: Zheng J, Li D, Haacke ME. “Three-Dimensional Contrast Enhanced Coronary Artery Imaging”. First Prize Poster Award, Fast Imaging Workshop, October, Montreal, CA.
  • 2004: Zhang H, Zheng J. “Steady-State Measurements of Myocardial Blood Flow in A Canine Model with Coronary Artery Stenosis”. Young Investigator Awards, AHA/NASCI, Cardiovascular Imaging, 32nd Annual Meeting & Scientific Sessions of the North American Society for Cardiac Imaging, Amelia Island, FL.
  • 2007: McCommis K, Goldstein TA, Zhang H, Misselwitz B, Gropler RJ, Zheng J. "Quantification of Myocardial Blood Volume During Dipyridamole and Dobutamine Stress: A Perfusion MRI Study." J Cardiovasc Magn Reson, 2007; 9:785-792. Second Place, Pohost Best JCMR Paper of 2007 Award.
  • 2008: McCommis K, Goldstein TA, Gropler RJ, Zheng J. "Detection of Changes in Myocardial Blood Flow and Volume: A CMR Study in a Canine Model of Coronary Artery Stenosis." First Place, Young Investigator Award in Basic Science. SCMR, February, Los Angeles, CA.

 

Disclosure of Financial Interest with Industry

None relevant to research.

 

Other

Mentor for biomedical engineering, biology, and medical students.

 

Key Publications

  1. Zheng J, Li D, Maggioni F, Klocke FJ, Abendschein D, Simonetti OP, Laub G, Gropler RJ, Finn JP, Cavagna FM. "Single Session MR Coronary Angiography and Myocardial Perfusion Imaging Using the New Blood Pool Compound B-22956 (Gadocoletic Acid): Initial Experience in a Porcine Model of Coronary Artery Disease." Invest Radiol, 2005; 40: 604-613.
  2. McCommis KS, Zhang HS, Goldstein TA, Misselwitz B, Abendschein D, Gropler RJ, Zheng J. "Myocardial Blood Volume Is Associated with Myocardial Oxygen Consumption: An Experimental Study with CMR in a Canine Model". JACC Cardiovasc Imaging, 2009; 2: 1313-1320.
  3. McCommis KS, Goldstein TA, Abendschein DR, Herrero P, Misselwitz B, Gropler RJ, Zheng J. "Quantification of Regional Myocardial Oxygenation by Magnetic Resonance Imaging: Validation with Positron Emission Tomography." Circ Cardiovasc Imaging, 2009; 3: 41-46.
  4. Tang D, Teng Z, Canton G, Yang C, Ferguson M, Huang X, Zheng J, Woodard PK, Yuan C. "Sites of Rupture in Human Atherosclerotic Carotid Plaques Are Associated With High Structural Stresses. An In Vivo MRI-Based 3D Fluid-Structure Interaction Study." Stroke, 2009; 40: 3258-3263.
  5. McCommis KS, Goldstein TA, Abendschein D, Misselwitz B, Pilgram T, Gropler RJ, Zheng J. "Roles of Myocardial Blood Volume and Flow in Coronary Artery Disease:  An Experimental MRI Study at Rest and During Hyperemia." European Radiology, 2010; 20: 2005 – 2012.
  6. McCommis KS, O‘Connor R, Donna L, Woodard PK, Gropler RJ, Zheng J. "Quantification of Global and Regional Myocardial Oxygenation in Humans: Initial Experiences." J Cardiovasc Magn Reson, 2010; 12:34.
  7. Vogel-Claussen J, Skrok J, Shehata ML, Singh S, Sibley CT, Boyce DM, Lechtzin N, Girgis RE, Mathai SC, Goldstein TA, Zheng J, Lima JA, Bluemke DA, Hassoun PM. "Right and Left Ventricular Myocardial Perfusion Reserves Correlate with Right Ventricular Function and Pulmonary Hemodynamics in Patients with Pulmonary Arterial Hypertension." Radiology, 2011; 258:119-127.
  8. Tang D, Yang C, Zheng J, Canton G, Bach R, Hatsukami TS, Wang L, Yang D, Billiar KL, Yuan C. "Image-Based Modeling and Precision Medicine: Patient-Specific Carotid and Coronary Plaque Assessment and Predictions." IEEE Trans Biomed Eng, 2013; 60:643-651.
  9. Zheng J. “Myocardial Oxygenation Imaging: New Methods for Ischemia Detection”. Curr Cardiovasc Imaging Rep, 2011; 2:159–164.
  10. Zheng J, Hasting MK, Zhang X, Coggan A, An H, Snozek D, Curci J, Mueller MJ. "Regional Perfusion and Oxygenation in Calf Muscles Are Attenuated in Diabetes: Pilot Outcomes From a Novel, Non-Invasive Measure." J Vas Surg, 2014; 59:419-426.