Elucidating the Biology and Biophysics of Living Systems: From Mouse to Man
The Biomedical Magnetic Resonance Laboratory (BMRL) and its collaborators advance and apply magnetic resonance spectroscopy (MRS) and imaging (MRI) for the study of biological systems. BMRL scientists allow and motivate a “mouse to man” translation of MR methods developed through preclinical MR imaging. A major area of BMRL research is the improvement of MR techniques and data analysis procedures to provide a more complete understanding of the complex microstructure and governing biophysical and physiologic determinants of healthy and diseased mammalian tissues in the intact functioning state. The BMRL develops and makes available an extensive software toolbox of Bayesian probability-theory-based algorithms for application to a variety of problems encountered in MRI and MRS. The BMRL and the Small-Animal Magnetic Resonance Facility provide the intellectual, instrumentation and peripheral resources to support state-of-the-art preclinical MR imaging to the Washington University, St. Louis region, national and international research communities.