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Biomedical Magnetic Resonance Laboratory (BMRL)

Dmitriy Yablonskiy

Contact Information
Washington University School of Medicine
Biomedical Magnetic Resonance Laboratory
Campus Box 8227
4525 Scott Avenue
St. Louis, MO 63110
(314) 362-1815

Current Position
Professor of Radiology

Research Interests
I am an MRI physicist with 20 years of experience in developing theoretical biophysical models of biological tissue structure and functioning. We use these models for designing new MRI techniques and applying them to study structure and functioning of different human organs in health and in disease. I have authored and co-authored about 200 papers in peer-review journals in the areas of MRI, physiology, and theoretical physics.

My lab has developed several advanced quantitative MRI-based methods for in vivo studying of humans and animals, which include the in vivo lung morphometry with hyperpolarized 3He MRI, the Gradient Echo Plural Contrast Imaging (GEPCI), and the quantitative BOLD (qBOLD).  These, and other methods developed in my lab allow early detection and diagnosis of changes in lung microstructure in health and diseases, quantification of tissue damage in multiple sclerosis, Alzheimer and other CNS diseases, thus providing safe and non-invasive in vivo biomarkers for monitoring disease progression. This opens a door to improving longitudinal studies in clinical and research trials.

Key Publications (selected from more than 200 peer review papers)

  • Yablonskiy DA, Haacke EM. Theory of NMR signal behavior in magnetically inhomogeneous tissues: the static dephasing regime. Magn Reson Med 1994;32(6):749-763.
  • Yablonskiy DA, Ackerman JJ, Raichle ME. Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation. Proc Natl Acad Sci USA 2000;97(13):7603-7608.
  • Yablonskiy DA, Sukstanskii AL, Leawoods JC, Gierada DS, Bretthorst GL, Lefrak SS, Cooper JD, Conradi MS. Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI. Proc Natl Acad Sci U S A 2002;99(5):3111-3116.
  • Zhu M, Ackerman JJ, Sukstanskii AL, Yablonskiy DA. How the body controls brain temperature: the temperature shielding effect of cerebral blood flow. J Appl Physiol 2006;101(5):1481-1488.
  • He X, Yablonskiy DA. Quantitative BOLD: mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: default state. Magn Reson Med 2007;57(1):115-126.
  • He X, Yablonskiy DA. Biophysical mechanisms of phase contrast in gradient echo MRI. Proc Natl Acad Sci U S A 2009;106(32):13558-13563.
  • Yablonskiy DA, Sukstanskii AL, Woods JC, Gierada DS, Quirk JD, Hogg JC, Cooper JD, Conradi MS. Quantification of lung microstructure with hyperpolarized 3He diffusion MRI. J Appl Physiol 2009;107(4):1258-1265.
  • Sati P, Cross AH, Luo J, Hildebolt CF, Yablonskiy DA. In vivo quantitative evaluation of brain tissue damage in multiple sclerosis using gradient echo plural contrast imaging. Neuroimage 2010;51(3):1089-1097.
  • Luo J, Jagadeesan BD, Cross AH, Yablonskiy DA. Gradient Echo Plural Contrast Imaging - Signal model and derived contrasts: T2*, T1, Phase, SWI, T1f, FST2*and T2*-SWI. Neuroimage 2012;60(2):1073-1082.
  • Yablonskiy DA, Luo J, Sukstanskii AL, Iyer A, Cross AH. Biophysical mechanisms of MRI signal frequency contrast in multiple sclerosis. Proc Natl Acad Sci U S A 2012;109(35):14212-14217.
  • Yablonskiy DA, Sukstanskii AL. Theoretical models of the diffusion weighted MR signal. NMR Biomed 2010;23(7):661-681.
  • Quirk JD, Lutey BA, Gierada DS, Woods JC, Senior RM, Lefrak SS, Sukstanskii AL, Conradi MS, Yablonskiy DA. In vivo detection of acinar microstructural changes in early emphysema with 3He lung morphometry. Radiology 2011;260(3):866-874.
  • Yablonskiy DA, Sukstanskii AL, He X. Blood oxygenation level-dependent (BOLD)-based techniques for the quantification of brain hemodynamic and metabolic properties - theoretical models and experimental approaches. NMR Biomed 2013;26(8):963-986.
  • Yablonskiy DA, Sukstanskii AL, Luo J, Wang X. Voxel spread function method for correction of magnetic field inhomogeneity effects in quantitative gradient-echo MRI. Magn Reson Med 2013;70(5):1283-1292.
  • Yablonskiy DA, Sukstanskii AL, Quirk JD, Woods JC, Conradi MS. Probing lung microstructure with hyperpolarized noble gas diffusion MRI: theoretical models and experimental results. Magn Reson Med 2013;71(2):486-505.
  • Luo J, Yablonskiy DA, Hildebolt CF, Lancia S, Cross AH. Gradient echo magnetic resonance imaging correlates with clinical measures and allows visualization of veins within multiple sclerosis lesions. Mult Scler 2014;20(3):349-355.
  • Wen J, Cross AH, Yablonskiy DA. On the role of physiological fluctuations in quantitative gradient echo MRI: implications for GEPCI, QSM, and SWI. Magn Reson Med 2014.
  • Yablonskiy DA, He X, Luo J, Sukstanskii AL. Lorentz sphere versus generalized Lorentzian approach: What would lorentz say about it? Magn Reson Med 2014;72(1):4-7.
  • Yablonskiy DA, Sukstanskii AL. Biophysical mechanisms of myelin-induced water frequency shifts. Magn Reson Med 2014;71(6):1956-1958.

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