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Biomedical Magnetic Resonance Laboratory (BMRL)

Jie Wen

Contact Information
Washington University School of Medicine
Biomedical Magnetic Resonance Laboratory
Campus Box 8227
4525 Scott Avenue
St. Louis, MO 63110
(314) 273-1650
jiewen@wustl.edu

Current Position
Instructor in Radiology

Research Interests
Our research interests focus on developing and applying quantitative MRI methods to study various diseases, including multiple sclerosis (MS), schizophrenia & bipolar disorder, traumatic brain injury (TBI), Alzheimer's disease (AD) and cancer. We have developed a method to correct physiological fluctuation induced artifacts. This method has been successfully applied to improve the quality of many imaging techniques, including susceptibility weighted imaging (SWI), quantitative susceptibility mapping (QSM) and gradient echo plural contrast imaging (GEPCI). We also developed and validated a quantitative MRI technique – simultaneous multi-angular relaxometry of tissue with magnetic resonance imaging (SMART MRI), which provides multiple quantitative relaxometry measurements. Our recent projects include using quantitative GEPCI technique to study multiple sclerosis and developing a B1 mapping technique for SMART MRI.

Key Publications

  1. Sukstanskii AL, Wen J, Cross AH, Yablonskiy DA. Simultaneous multi-angular relaxometry of tissue with MRI (SMART MRI): Theoretical background and proof of concept. Magn Reson Med. 2016 Mar 15. doi: 10.1002/mrm.26176. PubMed PMID: 26991525.
  2. Zhao Y, Wen J, Cross AH, Yablonskiy DA. On the relationship between cellular and hemodynamic properties of the human brain cortex throughout adult lifespan. Neuroimage. 2016 Jun;133:417-29. doi: 10.1016/j.neuroimage.2016.03.022. PubMed PMID: 26997360; PubMed Central PMCID: PMC4889562.
  3. Mamah D, Wen J, Luo J, Ulrich X, Barch DM, Yablonskiy D. Subcomponents of brain T2* relaxation in schizophrenia, bipolar disorder and siblings: A Gradient Echo Plural Contrast Imaging (GEPCI) study. Schizophr Res. 2015 Dec;169(1-3):36-45. doi: 10.1016/j.schres.2015.10.004. PubMed PMID: 26603058; PubMed Central PMCID: PMC4681636.
  4. Wen J, Yablonskiy DA, Luo J, Lancia S, Hildebolt C, Cross AH. Detection and quantification of regional cortical gray matter damage in multiple sclerosis utilizing gradient echo MRI. Neuroimage Clin. 2015 Aug 18;9:164-75. doi: 10.1016/j.nicl.2015.08.003. PubMed PMID: 27330979; PubMed Central PMCID: PMC4907986.
  5. Wen J, Cross AH, Yablonskiy DA. On the role of physiological fluctuations in quantitative gradient echo MRI: implications for GEPCI, QSM, and SWI. Magn Reson Med. 2015 Jan;73(1):195-203. doi: 10.1002/mrm.25114. PubMed PMID: 24482009; PubMed Central PMCID: PMC4116475.
  6. Wen J, Zhou P, Wu J. Efficient acquisition of high-resolution 4-D diagonal-suppressed methyl-methyl NOESY for large proteins. J Magn Reson. 2012 May;218:128-32. doi: 10.1016/j.jmr.2012.02.021. PubMed PMID: 22464875; PubMed Central PMCID: PMC3625671.
  7. Wen J, Wu J, Zhou P. Sparsely sampled high-resolution 4-D experiments for efficient backbone resonance assignment of disordered proteins. J Magn Reson. 2011 Mar;209(1):94-100. doi: 10.1016/j.jmr.2010.12.012. PubMed PMID: 21277815; PubMed Central PMCID: PMC3048770.

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