Cornelius von Morze
Washington University School of Medicine
Biomedical Magnetic Resonance Laboratory
Campus Box 8227
4525 Scott Avenue
St. Louis, MO 63110
Instructor in Radiology
Dr. von Morze has joined the Department of Radiology at Washington University to lead a new program in hyperpolarized (HP) 13C MRI research, applying the method of dissolution dynamic nuclear polarization (DNP) first described in 2003 by Ardenkjaer-Larsen et al. The transformative signal enhancement provided by this approach (up to five orders of magnitude) offers unique potential for probing pathophysiologic metabolic changes in vivo. Primary interests are-- 1) MR engineering: Pulse sequences for localized direct and indirect detection of HP 13C magnetization, design and construction of novel radiofrequency coils for HP 13C studies and other MR hardware. 2) Development and characterization of metabolically active HP 13C probes, including associated kinetic models needed to capture fundamental metabolic information. 3) NAFLD: Supported by a new NIDDK R01 (role: co-PI), Dr. von Morze is particularly interested in applying HP 13C as well as other new MR technologies toward outstanding diagnostic problems in non-alcoholic fatty liver and steatohepatitis.
- von Morze C, Reed G, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME. “In vivo hyperpolarization transfer in a clinical MRI scanner”. Magnetic Resonance in Medicine. 2018 Aug;80(2):480-487.
- von Morze C, Allu PK, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D. “Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo”. Scientific Reports. 2018; 8(2088).
- von Morze C, Merritt ME. “Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon-13 MRI technology” (review). NMR in Biomedicine. 2018 Jun. e3937.
- von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. “Direct assessment of renal mitochondrial redox state using hyperpolarized 13C-acetoacetate”. Magnetic Resonance in Medicine. 2018 Apr;79(4):1862-1869.
- von Morze C, Larson PEZ, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. “Imaging of blood flow using hyperpolarized [13C]urea in preclinical cancer models”. Journal of Magnetic Resonance Imaging. 2011 Mar;33(3):692-7.
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