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Biomedical Magnetic Resonance Laboratory (BMRL)

Peng Sun

Contact Information
Washington University School of Medicine
Biomedical Magnetic Resonance Laboratory
Campus Box 8227
4525 Scott Avenue
St. Louis, MO 63110
(314) 286-2459
pengsun@wustl.edu

Current Position
Assistant Professor of Radiology

Research Interests
Diffusion MR imaging is being widely used for studying the diseases of the central nervous system (CNS). My research has been focused on the applications of diffusion MRI to investigate WM injuries in CNS, and I have been involved in a wide range of methodology developments and clinical applications on brain, spinal cord and optic nerve. This has encompassed development and implementation of novel acquisition methods and MR sequences; imaging protocol design for fast and high-resolution MR imaging; implementation of MR image post-processing pipeline. Applications include spinal cord injury (SCI), multiple sclerosis, traumatic brain injury and stroke.

Key Publications

  1. Strain J.F., Burdo T., Song S.K., Sun P., El-Ghazzawy O., Nelson B., Elizabeth W., Baker L., Vaida F., Ances B.M., Diffusion Basis Spectral Imaging Detects Ongoing Brain Inflammation in Virologically Well Controlled HIV+ Patients, Journal of Acquired Immune Deficiency Syndromes, 2017, PMID: 28796748
  2. Lin T.H., Chiang C.W., Perez-Torres C.J., Sun P., Wallendorf M., Schmidt R.E., Cross, A.H., Song S.W., Diffusion MRI quantifies early axonal loss in the presence of nerve swelling, Journal of Neuroinflammation, 2017 Apr 7;14(1):78. doi: 10.1186/s12974-017-0852-3.
  3. Sun P., Murphy R., Gamble P., George A., Song S.K., Ray W., Diffusion Assessment of Cortical Changes, Induced by Traumatic Spinal Cord Injury. Brain Sci. 2017, 7(2), 21; doi:10.3390/brainsci7020021
  4. Murphy R., Sun P., Han R., Griffin K., Wagner J., Wright N., Dorward I., Kelly M., Riew D., Santiago P., Zebala L., Trinkaus K., Ray W., Song S.K., Fractional Anisotropy to Quantify Cervical Spondylotic Myelopathy Severity, Journal of Neurosurgical Sciences 2016,  PMID: 27149369
  5. Murphy R., Sun P.* (equal contribution), Xu J., Wang Y., Sullivan S., Gamble P., Wagner J., Wright N., Dorward I., Riew D., Santiago P., Kelly M., Trinkaus K., Ray W., Song S.K., Magnetic resonance imaging biomarker of axon loss reflects cervical spondylotic myelopathy severity. Spine 2016. PMID: 26650876
  6. Wang Y., Sun P., Wang Q., Wang X., Trinkaus K., Schmidt R. E., Naismith R. T., Cross A. H., and Song S.-K., Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis, Brain Feb 2015, DOI: 10.1093/brain/awv046
  7. Chiang C.W., Wang Y., Sun P., Lin T.H., Trinkaus K., Cross A.H., Song S.K., Quantifying white matter tract diffusion parameters in the presence of increased extra-fiber cellularity and vasogenic edema. NeuroImage 2014. DOI: 10.1016/j.neuroimage.2014.06.064
  8. Wang X. , Cusick M.F. , Wang Y., Sun P., Libbey J.E., Fujinami R.S. Song S.K., Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice, NMR in biomedicine 2014.  doi: 10.1002/nbm.3129
  9. Lin T.-H., Chiang C.-W., Trinkaus K., Spees W. M., Sun P. and Song, S.-K., Manganese-enhanced MRI (MEMRI) via topical loading of Mn2+ significantly impairs mouse visual acuity: a comparison with intravitreal injection. NMR Biomed. 2014 doi: 10.1002/nbm.3073
  10. Zhang X., Sun P*.( equal contribution), Wang J., Wang Q., Song S.K., Diffusion Tensor imaging detects retinal ganglion cell axon damage in the mouse model of optic nerve crush, Invest Ophthalmol Vis Sci. 2011 Sep 1;52(9):7001-6.
  11. Wang Y., Wang Q., Haldar J.P., Yeh F.C., Xie M., Sun P., Tu T.W., Trinkaus K., Klein R.S., Cross A.H., Song S.K., Quantification of increased cellularity during inflammatory demyelination, Brain. 2011 Dec;134(Pt 12):3590-601
  12. Özcan A., Quirk J.D., Wang Y., Wang Q., Sun P., Spees W.M., Song S.K., The Validation of Complete Fourier Direct MR Method for Diffusion MRI via Biological and Numerical Phantoms, Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3756-9
  13. Spees W.M., Buhl N., Sun P., Ackerman J.J., Neil J.J., Garbow J.R., J Quantification and compensation of eddy-current-induced magnetic-field gradients, Magn Reson. 2011 Sep;212(1):116-23

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