Biomedical Magnetic Resonance Laboratory (BMRL)


Peng Sun

Contact Information
Washington University School of Medicine
Biomedical Magnetic Resonance Laboratory
Campus Box 8227
4525 Scott Avenue
St. Louis, MO 63110
(314) 286-2459

Current Position
Assistant Professor of Radiology

Research Interests
Diffusion MR imaging is being widely used for studying the diseases of the central nervous system (CNS). My research has been focused on the applications of diffusion MRI to investigate WM injuries in CNS, and I have been involved in a wide range of methodology developments and clinical applications on brain, spinal cord and optic nerve. This has encompassed development and implementation of novel acquisition methods and MR sequences; imaging protocol design for fast and high-resolution MR imaging; implementation of MR image post-processing pipeline. Applications include spinal cord injury (SCI), multiple sclerosis, traumatic brain injury and stroke.

Selected Peer-Reviewed Journal Publications (* Equal contribution; # Corresponding)
Complete List: 

  1. Ye Z., George A., Wu A., Niu X., Lin J., Adusumilli G., Naismith R.T., Cross A.H., Sun P.#, Song S.K., A Deep Learning based Diffusion Histology Imaging for Mulitple Scrolesis Lesion Classification, Annals of Clinical and Translational Neurology, 2020.  doi: 10.1002/acn3.51037.
  2. Samara A., Murphy T., Strain J., Rutlin J., Sun P., Neyman O., Sreevalsan N., Shimony J.S., Ances B., Song S.K., Hershey T., Eisenstein S.A., Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging. 2020. Front. Hum. Neurosci. 13:464. doi: 10.3389/fnhum.2019.00464
  3. Sun P., George A., Perantie D, Trinkaus K., Ye Z., Naismith R.T., Song S.-K., Cross A.H., Diffusion Basis Spectrum Imaging Provides Insights into Multiple Sclerosis Pathology, Neurology Neuroimmunology & Neuroinflammation, 2020, DOI: 10.1212/NXI.0000000000000655
  4. Shirani A., Sun P., Trinkaus K., Perantie D., George A., Naismith R., Song S.K., Cross A.H. Diffusion basis spectrum imaging for identifying pathologies in MS subtypes, Annals of Clinical and Translational Neurology, 2019. doi: 10.1002/acn3.50903
  5. Kim J.-W., Andersson L.J., Seifert A., Sun P., Song S.-K., Dula C.; Naismith R. T., Xu J., Incorporating non-linear alignment and multi-compartmental modeling for improved human optic nerve diffusion imaging. NeuroImage. 2019; 196: 102-13
  6. Lin TH*, Sun P.*, Hallman M, Hwang FC, Wallendorf M, Ray WZ, et al. Noninvasive Quantification of Axonal Loss in the Presence of Tissue Swelling in Traumatic Spinal Cord Injury Mice. J Neurotrauma. 2019.
  7. Spees WM, Lin TH, Sun P., Song C, George A, Gary SE, et al. MRI-based assessment of function and dysfunction in myelinated axons. PNAS. 2018;115(43):E10225-E34.
  8. Shirani A., Sun P., Schmidt R.E., Trinkaus K., Song S.K., Cross A.H. Histopathological correlation of diffusion basis spectrum imaging in human brain biopsy tissue of an inflammatory demyelinating lesion: a brief report, Multiple Sclerosis Journal, 2018, DOI: 10.1177/1352458518786072
  9. Adusumilli G., Trinkaus K., Sun P., Lancia S., Viox J., Wen J., Naismith R.T., Cross A.H., Intensity Ratio to Improve Black Hole assessment in Multiple Sclerosis, Multiple Sclerosis Journal, 2018. DOI: 10.1016/j.msard.2017.11.
  10. Strain J.F., Burdo T., Song S.K., Sun P., El-Ghazzawy O., Nelson B., Elizabeth W., Baker L., Vaida F., Ances B.M., Diffusion Basis Spectral Imaging Detects Ongoing Brain Inflammation in Virologically Well Controlled HIV+ Patients, Journal of Acquired Immune Deficiency Syndromes, 2017, PMID: 28796748
  11. Sun P., Murphy R., Gamble P., George A., Song S.K., Ray W., Diffusion Assessment of Cortical Changes, Induced by Traumatic Spinal Cord Injury. Brain Sci. 2017, 7(2), 21; doi:10.3390/brainsci7020021
  12. Murphy R., Sun P., Han R., Griffin K., Wagner J., Wright N., Dorward I., Kelly M., Riew D., Santiago P., Zebala L., Trinkaus K., Ray W., Song S.K., Fractional Anisotropy to Quantify Cervical Spondylotic Myelopathy Severity, Journal of Neurosurgical Sciences 2016, PMID: 27149369
  13. Murphy R. *, Sun P.*, Xu J., Wang Y., Sullivan S., Gamble P., Wagner J., Wright N., Dorward I., Riew D., Santiago P., Kelly M., Trinkaus K., Ray W., Song S.K., Magnetic resonance imaging biomarker of axon loss reflects cervical spondylotic myelopathy severity. Spine 2016. PMID: 26650876
  14. Wang Y., Sun P., Wang Q., Wang X., Trinkaus K., Schmidt R. E., Naismith R. T., Cross A. H., and Song S.-K., Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis, Brain Feb 2015, DOI: 10.1093/brain/awv046

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