Biomedical Magnetic Resonance Laboratory (BMRL)

James D. Quirk

Contact Information
Washington University School of Medicine
Biomedical Magnetic Resonance Laboratory
Campus Box 8227
4525 Scott Avenue
St. Louis, MO 63110
(314) 362-3875

Current Position
Associate Professor of Radiology
Director, Small-Animal Magnetic Resonance Facility

Research Interests
Our main research focus is the use of hyperpolarized noble gas MRI as a biomarker for the detection and characterization of pulmonary diseases as part of a multi-disciplinary imaging team across the Departments of Radiology, Physics, and Internal Medicine.  Recent projects include measuring pulmonary ventilation and acinar microstructure in healthy controls and subjects with COPD, asthma, post-pneumonectomy, and post-lung transplantation.

We also utilize MRI to non-invasively study animal models of musculoskeletal disorders as part of an ongoing collaboration with the Washington University Musculoskeletal Research Core.  Recent projects include characterizing the onset and progression of arthritic changes in the mouse knee, phenotyping fat deposition patterns in transgenic mouse models, and measuring angiogenic changes in the rat forelimb following bone microfracture.

Key Publications

  • J. D. Quirk, Y. V. Chang, D. A. Yablonskiy, “In Vivo Lung Morphometry with Hyperpolarized 3He Diffusion MRI:  Reproducibility and the Role of Diffusion-Sensitizing Gradient Direction.”, Magnetic Resonance in Medicine, 2014, DOI: 10.1002/mrm.25241.
  • Y. V. Chang, J. D. Quirk, D. A. Yablonskiy, “In Vivo Lung Morphometry with Accelerated Hyperpolarized 3He Diffusion MRI:  A Preliminary Study.”, Magnetic Resonance in Medicine, DOI: 10.1002/mrm.25284.
  • F. Pennati, J. D. Quirk, D. A. Yablonskiy, M. Castro, A. Aliverti, J. C. Woods.  “Assessment of Regional Lung Function by Multi-Volume 1H-MRI in Health and Obstructive Lung Disease:  Comparison with 3He-MRI. Radiology 2014.  Accepted.
  • R. E. Tomlinson, A. H. Schmieder, J. D. Quirk, G. M. Lanza, M. J. Silva. “Antagonizing the alpha beta Integrin Inhibits Angiogenesis and Impairs Woven but Not Lamellar Bone Formation Induced by Mechanical Loading.” Journal of Bone and Mineral Research (2014), DOI 10.1002/jbmr.2223.
  • D. A. Yablonskiy, A. L. Sukstanskii, J.D. Quirk, J. C. Woods, M. S. Conradi, “Probing Lung Microstructure with Hyperpolarized Noble Gas Diffusion MRI:  Theoretical Models and Experimental Results.”, Magnetic Resonance in Medicine, 71 (2014), p.486-505.
  • Y.V. Chang, J.D. Quirk, I.C. Ruset, J.J. Atkinson, F.W. Hersman, J.C. Woods, “Quantification of human lung structure and physiology using hyperpolarized Xe.” Magnetic Resonance in Medicine 71 (2014), p. 339-344.
  • A. J. Hajari, D. A. Yablonskiy, A. L. Sukstanskii, J. D. Quirk, M. S. Conradi, J. C. Woods, “Morphometric Changes in the Human Pulmonary Acinus During Inflation.”, J Appl Physiol., 112 (2012), p. 937-43.
  • J. D. Quirk, B. A. Lutey, D. S. Gierada, J. C. Woods, R. M. Senior, S. S. Lefrak, A. L. Sukstanskii, M. S. Conradi, and D. A. Yablonskiy, “In Vivo Detection of Acinar Microstructural Changes in Early Emphysema with 3He Lung Morphometry.”, Radiology, 260 (2011), p. 866-874.
  • A. J. Hajari, D. A. Yablonskiy, J. D. Quirk, A. L. Sukstanskii, R. A. Pierce, G. Deslee, M. S. Conradi, and J. C. Woods, “Imaging alveolar-duct geometry during expiration via 3He lung morphometry.”  J Appl Physiol, 110 (2011), p. 1448-54.
  • E. Osmanagic, A. L. Sukstanskii, J. D. Quirk, J. C. Woods, R. A. Pierce, M. S. Conradi, E. R. Weibel, and D. A. Yablonskiy, “Quantitative assessment of lung microstructure in healthy mice using an MR-based 3He lung morphometry technique.” J Appl Physiol., 109 (2010), p. 1592-9.
  • T. K. Pilgram, J. D. Quirk, A. J. Bierhals, R. D. Yusen, S. S. Lefrak, J. D. Cooper, D. S. Gierada, “Accuracy of Emphysema Quantification Performed with Reduced Numbers of CT Sections.”, American Journal of Roentgenology, 194 (2010), p. 585-591.
  • D. A. Yablonskiy, A. L. Sukstanskii, J. C. Woods, D. S. Gierada, J. D. Quirk, J. C. Hogg, J. D. Cooper, M. S. Conradi, “Quantification of Lung Microstructure with Hyperpolarized 3He Diffusion MRI.”, Journal of Applied Physiology, 107 (2009), p.1258-1265.
  • J. D. Quirk, A. L. Sukstanskii, G. L. Bretthorst, D. A. Yablonskiy, “Optimal Decay Rate Constant Estimates From Phased Array Data Utilizing Joint Bayesian Analysis.”, Journal of Magnetic Resonance, 198 (2009), p. 49-56.
  • A. Bashir, M. S. Conradi, J. C. Woods, J. D. Quirk, D. A. Yablonskiy, “Calibration of RF Transmitter Voltages for Hyperpolarized Gas MRI.”, Magnetic Resonance in Medicine, 61 (2009), p. 239-243.
  • B. A. Lutey, S. S. Lefrak, J. C. Woods, T. Tanoli, J. D. Quirk, A. Bashir, D. A. Yablonskiy, M. S. Conradi, S. T. Bartel, T. K. Pilgram, J. D. Cooper, and D. S. Gierada, “Hyperpolarized 3He MR Imaging: Physiologic Monitoring Observations and Safety Considerations in 100 Consecutive Subjects.”, Radiology, 248 (2008), p. 655-661.
  • J. D. Quirk, A. L. Sukstanskii, D. S. Gierada, J. C. Woods, M. S. Conradi, and D. A. Yablonskiy. “Models and Applications of in vivo Lung Morphometry with Hyperpolarized 3He MRI in a Mild COPD Population”. In: Hurlimann MD, Song YQ, Fantazzini P, Bortolotti V, editors. AIP Conference Proceedings; 2008; Cambridge, MA. American Institute of Physics. p 29-31. (AIP Conference Proceedings).
  • M. W. Tengowski, J. M. Lapointe, J. D. Quirk, J. Z. Long, D. T. Stephenson, M. E. Elwell, R. A. Valdez, C. M. Matherne, J. J. Kotyk.  “Early Changes In Renal Blood Flow As Detected With DCE MRI Predict Imminent Pathology In A Rat Model Of Renal Papillary Necrosis: Developing A Drug Safety Biomarker.”  Mol Imaging Biol 7(2):119 (2005) , A146.
  • J. D. Quirk, S. J. Baldwin, M. P. Harms, F. Eckstein, M. Hudelmaier, S. Wrubel, E. C. Arner, J. J. Kotyk, “Validation of MRI Cartilage Biomarkers in Rat Knee Osteoarthritis.” Osteoarthritis and Cartilage 12(Sup. 2) (2004), pp. S32-33.
  • J. D. Quirk, S. H. Kim, J. M. Thompson, S. J. Baldwin, K. S. Chinn, K. M. Shevlin, J. R. Hartke, E. C. Arner, J. J. Kotyk, “Monitoring Disease Progression in Rat Models of Arthritis Using Magnetic Resonance Imaging”.  Mol Imaging Biol  6(2) (2004), pp. 90-91.
  • J. D. Quirk, G. L. Bretthorst, T. Q. Duong, A. Z. Snyder, C. S. Springer, J. J. H. Ackerman, J. J. Neil, "Equilibrium Water Exchange Between the Intra- and Extracellular Spaces of Mammalian Brain".   Magnetic Resonance in Medicine.  50 (2003), pp. 493-9.

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For an up-to-date list of Dr. Quirk's publications please see his entry on PubMed.