Tsen-Hsuan (Abby) Lin
Washington University School of Medicine
Biomedical Magnetic Resonance Laboratory
Campus Box 8227
4525 Scott Avenue
St. Louis, MO 63110
Instructor in Radiology
Abby Lin’s research interests focus on white-matter function and pathology using advanced diffusion MRI. White matter bundle tracts play a key role to process sensory and cognitive information in the brain, and white matter tracts are the primary injury targets of many neurodegenerative diseases or traumatic injury. Abby collaborates with her colleagues, Drs. Song, Spees, and Sun, to develop and introduce
(1) diffusion fMRI: Previously, they reported ~27% ADC⊥ decreased in healthy mouse optic nerve during visual stimulation. Such axonal-activation ADC decrease was independent of vascular effects, which was a major different from conventional BOLD fMRI. In the subsequent study, they demonstrated that reduced ADC⊥ decrease in optic neuritis mice and correlated with the injury severity. Meanwhile, dfMRI was employed to assess mouse corpus callosum with electrical stimulation at S1BF cortex or mechanical whisker-deflection. dfMRI differentiated functional deficits in CC of cuprizone mice. After 5-week cuprizone feeding, mice developed severe demyelination at CC.
(2) Diffusion basis spectrum imaging (DBSI): DBSI was able to identify coexisting pathology in white or gray matter. Abby with her team have demonstrated that DBSI could detect inflammation, myelin damage, axonal injury, tissue loss in the mouse models of multiple sclerosis, traumatic brain injury, and Huntington’s disease, etc.
(3) Functional assessment with DBSI: Currently, Abby applies DBSI/dfMRI to study optic nerve and corpus callosum of EAE, cuprizone, traumatic brain injury (TBI), and Huntington’s disease mice to understand interplay of function deficits and pathology in CNS. Meanwhile, Abby and her team are translating DBSI with checkerboard visual stimulation to MS patients with optic neuritis and glaucoma patients. Their imaging methods can serve as outcome measures to assess optic nerve function/pathology and follow disease progression, validate treatment efficacy, and compensate the limitation of optic coherence tomography (OCT).
Selected Peer-reviewed Publications
- Lin TH, Sun P, Hallman M, Hwang FC, Wallendorf M, Ray WZ, Spees WM, Song SK. Noninvasive Quantification of Axonal Loss in the Presence of Tissue Swelling in Traumatic Spinal Cord Injury Mice. J Neurotrauma. 2019 Jan 11; PubMed PMID: 30501460.
- Zhan J, Lin TH, Libbey JE, Sun P, Ye Z, Song C, Wallendorf M, Gong H, Fujinami R, Song SK. Diffusion Basis Spectrum and Diffusion Tensor Imaging Detect Hippocampal Inflammation and Dendritic Injury in a Virus-Induced Mouse Model of Epilepsy. Frontiers in Neuroscience 2018 Feb.15; 12(77); PMID:29497358
- Spees WM, Lin TH, Sun P, Song C, George A, Gary SE, Yang HC, Song SK. MRI-based assessment of function and dysfunction in myelinated axons. Proc Natl Acad Sci. USA 2018 Oct. 23; 115(43): E10225-E12345; PubMed PMID: 30297414.
- Lin TH, Chiang CW, Perez-Torres CJ, Sun P, Wallendorf M, Schmidt RE, Cross AH, Song SK. Diffusion MRI quantifies early axonal loss in the presence of nerve swelling. J Neuroinflammation. 2017 Apr 7;14(1):78; PubMed PMID: 28388913.
- Lin TH, Spees WM, Chiang CW, Trinkaus K, Cross AH, Song SK. Diffusion fMRI detects white-matter dysfunction in mice with acute optic neuritis. Neurobio Dis. 2014 July 67;1-8. PubMed PMID: 24632420.
- Lin TH, Chiang CW, Trinkaus K, Spees WM, Sun P, Song SK: “Manganese-Enhanced MRI (MEMRI) via topical loading of Mn2+ significantly impairs mouse visual acuity: a comparison with intravitreal injection,” NMR in Biomedicine (2014) 27: 390-398 PMID: 24436112;
- Lin TH, Kim JH, Perez-Torres C, Chiang CW, Trinkaus K, Cross AH, Song SK: “Axonal transport decreased at the onset of optic neuritis in EAE mice,” NeuroImage (2014) 100: 244-253 PMID: 24936685;
- Spees WM, Lin TH, Song SK. White-matter diffusion fMRI of mouse optic nerve. Neuroimage. 2013 Jan 15; 65:209-15. PubMed PMID: 23085108; PubMed Central PMCID: PMC3513522.
Selected Peer-reviewed Conference Abstracts
- Lin TH, Spees WM, Wallendorf M, Shih YY Ian, Cross AH, Song SK: “Diffusion fMRI of Mouse Optic Nerve with Antidromic Electrical Stimulation”, Proceedings of the 25th Annual Meeting of the International Society for Magnetic Resonance in Medicine; 22 – 27 April 2017; Hawaii, USA: Traditional Poster (abstract # 2274).
- Lin TH, Spees WM, Wallendorf M, Shih YY Ian, Cross AH, Song SK: “Functional Response of Corpus Callosum to Electrical Stimulation of S1 Cortex in Mice”, Proceedings of the 25th Annual Meeting of the International Society for Magnetic Resonance in Medicine; 22 – 27 April 2017; Hawaii, USA: 463 (Oral presentation)
- Lin TH, Yang RM, Zhan J, Song C, Sun P, Wallendorf M, Cross AH, Song SK. “Assessing Fingolimod Axonal Protection Efficacy in Mouse Optic Neuritis Using Diffusion Basis Spectrum Imaging” Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum, 1 – 3 February 2018, San Diego, California: Poster & Oral presentation (abstract #117).
- Lin TH, Sauerbeck AD, Kummer TT, Song SK. “Assessing Mild Traumatic Brain Injury (TBI) Induced Optic Neuropathy in Novel Closed-head Injury Mouse Model Using Diffusion Basis Spectrum Imaging (DBSI)” Proceedings of the 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine; 16 – 21 June 2018; Paris, France: Oral (abstract # 3896).
- Lin TH, Shui YB, Liu Y, Yang HC, Wallendorf M, Siegfried CJ, Song SK. “Optical Coherence Tomography Detected Axonal Loss Failed to Identify Acute Optic Nerve Axonal Injury: A Diffusion MRI Study” 2018 The Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, Global Connections in Vision Research; 29 April – 3 May 2018; Honolulu, Hawaii: Oral presentation (abstract # 2907880).
- Lin TH, Sun P, Spees WM, George A, Yang HC, Wallendorf M, Cross AH, Xu J, Song SK: “Assessing Human Optic Nerve Function using Diffusion Basis Spectrum Imaging (DBSI)” Proceedings of the 27th Annual Meeting of the International Society for Magnetic Resonance in Medicine; 11 – 16 May 2019; Montreal, Canada: Oral (abstract # 5566).
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