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Biomedical Magnetic Resonance Laboratory (BMRL)

Joel R. Garbow

Contact Information
Washington University School of Medicine
Biomedical Magnetic Resonance Laboratory
Campus Box 8227
4525 Scott Avenue
St. Louis, MO 63110
(314) 362-9949
garbow@wustl.edu 

Current Position
Associate Laboratory Director
Professor of Radiology

Research Interests
With more than 30 years of experience in magnetic resonance imaging and spectroscopy, Garbow is well-recognized and respected for his work in magnetic resonance as applied to intact biological systems. Before joining Washington University, he spent more than 15 years at Monsanto Company, rising to the rank of Science Fellow and head of Monsanto’s MR laboratories. Garbow possesses superb communications and writing skills and is a valued collaborator at Washington University. He is an outstanding experimentalist, with extensive experience in experimental design, new technique development and pulse sequence programming. As a PI within the BMRL, Garbow’s research interests include the development and application of novel MR methodologies for the study of cancer and radiation-induced brain injury in pre-clinical, small-animal models. These efforts include the development and application of techniques for improving tumor detection and quantitatively monitoring tumor growth, the identification and validation of non-invasive imaging metrics that can serve as early surrogate markers for therapeutic response, and the development of imaging methods to characterize the development and time-to-progression of tissue injury in a novel model of radiation necrosis.

Key Publications

  1. C. J. Perez-Torres, J. A. Engelbach, J. Cates, D. Thotala, L. Yuan, R. E. Schmidt, K. M. Rich, R. E. Drzymala, J. J. H. Ackerman and J. R. Garbow. Towards Distinguishing Recurrent Tumor from Radiation Necrosis: DWI and MTC in a Gamma Knife® Irradiated Mouse Glioma Model. International Journal of Radiation Oncology, Biology, and Physics, in press (2014).
  2. X. Jiang, J. A. Engelbach, L. Yuan, J. Cates, F. Gao., R. E. Drzymala, D. E. Hallahan, K. M. Rich, R. E. Schmidt, J. J. H. Ackerman, and J. R. Garbow. Anti-vegf antibodies mitigate the development of radiation necrosis in mouse brain. Clinical Cancer Research, in press (2014), Epub 2014/03/22.
  3. X. Jiang, C. J. Perez-Torres, D. Thotala, J. A. Engelbach, L. Yuan, J. Cates, F. Gao, R. E. Drzymala, K. M. Rich, R. E. Schmidt, J. J. H. Ackerman, D. E. Hallahan, and J. R. Garbow. A GSK-3b inhibitor protects against radiation necrosis in mouse brain. International Journal of Radiation Oncology, Biology, and Physics, in press (2014).
  4. Y. Yin, T. Betsuyaku, J. R. Garbow, J. Miao, R. Govindan, D. M. Ornitz. Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3. Cancer Res 73, 5730-5741 (2013).
  5. K. I. Shoghi, J. Xu, Y. Su, J. He, D. Rowland, Y. Yan, J. R. Garbow, Z. Tu, L. A. Jones, R. Higashikubo, K. T. Wheeler, R. A. Lubet, R. Mach, M. You. Quantitative Receptor-based Imaging of Tumor Proliferation with the Sigma-2 Ligand [18F]ISO-1. PLOS ONE 8:e74188 (2013).
  6. A. S. Krupnick, V. K. Tidwell, J. A. Engelbach, V. V. Alli, A. Nehorai, M. You, H. G. Vikis, A. E. Gelman, D. Kreisel, and J. R. Garbow  Quantitative monitoring of murine lung tumors by magnetic resonance imaging. Nat Prot, 7, 128-142 (2012).
  7. V. K. Tidwell, J. R. Garbow, A. S. Krupnick, J. A. Engelbach, and A. Nehorai Quantitative analysis of tumor burden in mouse lung via MRI. Magn Reson Med, 67, 572-579 (2012).
  8. R. Avni, T. Raz, I. E. Biton, V. Kalchenko, J. R. Garbow, M. Neeman. Unique in utero identification of fetuses in multi-fetal mouse pregnancies by placental bi-directional arterial spin labeling (BD-ASL) MRI. Magn Reson in Medicine, 68, 560-570 (2012).
  9. T. Raz, R. Avni, Y. Addadi, Y. Cohen, A. J. Yaffa, B. Hemmings, J. R. Garbow, and M. Neeman. The hemodynamic basis for positional- and inter-fetal dependent effects in dual arterial supply of mouse pregnancies. PLoS ONE, 7, e52273 (2012).
  10. J. R. Garbow, J. M. Doherty, R. C. Schugar, S. Travers, M. L. Weber, A. E. Wentz, N. Ezenwajiaku, D. G. Cotter, E. M. Brunt, and P. A. Crawford. Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. Am J Physiol Gastrointest Liver Physiol, 300, G956-967 (2011). PMCID:PMC3119109
  11. J. R. Anderson, Q. Ye, J. J. Neil, J. J. Ackerman, J. R. Garbow. Diffusion effects on longitudinal relaxation in poorly mixed compartments. J. Magn Reson, 211, 30-36, (2011). PMCID: PMC3114270
  12. Z. Liu, A. Turkoz, E. N. Jackson, J. C. Corbo, J. A. Engelbach, J. R. Garbow, D. R. Piwnica-Worms, and R. Kopan. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clinical Investigation, 121, 800-08 (2010). PMCID:PMC3026721
  13. J. R. Garbow, A. C. Santeford, J. R. Anderson, J. A. Engelbach and J. M. Arbeit. Magnetic resonance imaging defines cervico-vaginal anatomy, cancer, and VEGF Trap antiangiogenic efficacy in estrogen-treated K14-HPV16 transgenic mice. Cancer Research, 69, 7945-7952 (2009).
  14. S. C. Jost, A. Hope, E. Kiehl, A. Perry, S. Travers, J. R. Garbow. A Novel Murine Model for Localized Radiation Necrosis and its Characterization using Advanced Magnetic Resonance Imaging. International Journal of Radiation Oncology, Biology, and Physics, 75, 527-533 (2009).
  15. J. R. Garbow, A. C. Santeford, J. R. Anderson, J. A. Engelbach and J. M. Arbeit. Magnetic resonance imaging defines cervico-vaginal anatomy, cancer, and VEGF Trap antiangiogenic efficacy in estrogen-treated K14-HPV16 transgenic mice. Cancer Research, 69, 7945-7952 (2009).

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For an up-to-date list of Dr. Garbow's publications please see his entry on PubMed and Scopius.