Postdoctoral Research Associate (PRTC, Chaney Lab)
The Chaney lab in the Mallinckrodt Institute of Radiology (MIR) at Washington University School of Medicine, St. Louis is seeking a highly motivated Postdoctoral Research Scholar to perform translational molecular imaging studies investigating the role of the immune system in neurological disease.
The emerging role of inflammation in the pathogenesis of neurodegenerative diseases is shifting the way we think about diagnosis and treatment of these conditions. Unfortunately, current approaches to probe immune function in vivo are limited. The Chaney lab focuses on developing and evaluating novel imaging biomarkers to investigate the inflammatory component of neurodegenerative diseases – an area at the interface of neuroscience, radiology and immunology. The overall goal is to enhance understanding of the immune system’s role in neurodegenerative diseases, and thus improve diagnosis and treatment of patients.
The successful applicant will have the opportunity to work on multidisciplinary and translational projects, utilize state-of-the-art imaging facilities and be exposed to a richly collaborative environment. They will have the opportunity to acquire and develop new skills spanning neuroscience, radiology and immunology, including clinical and preclinical neuroimaging and data analysis, autoradiography, immunohistochemistry and flow cytometry of CNS tissues. Leading projects, writing manuscripts, and applying for independent grants will be strongly encouraged and supported. The Chaney lab is a part of the Precision Radiotheranostics Translation Center within the Mallinckrodt Institute of Radiology (MIR).
Information on being a postdoc at Washington University in St. Louis can be found at https://postdoc.wustl.edu/prospective-postdocs-2/.
Primary Duties & Responsibilities
• Assists in the design and performance of studies pertaining to inflammation in neurological disease.
• Develops expertise in preclinical evaluation of PET tracers in animal models of inflammatory and neurological disease.
• Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
• Manages their own project, which should lead to a first author publication.
• Clinical image analysis of PET tracer uptake.
• Performance of immune profiling assays (e.g., flow cytometry, cytokines analyses).
• Protocol development and refinement.
• Assists with grant preparation and reporting.
• Conscientious discharge of research responsibilities.
• Maintains conformity with ethical standards in research.
• Maintains compliance with good laboratory practice including the maintenance of adequate research records.
• Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
• Maintains collegial conduct towards co-trainees, staff members and members of the research group.
• Adheres to all applicable university policies, procedures and regulations. All data, research records and materials and other intellectual property generated in university laboratories remain the property of the university.
Ph.D., M.D. or equivalent terminal or doctoral degree.
• Ph.D. in biomedical imaging, neuroscience, engineering, chemistry, immunology or related fields.
• Experience with small animal (PET/CT, MRI) or clinical imaging and analysis (PET/CT, MRI).
• Proficiency in statistics and statistical software.
• Detail-oriented and thorough scientific approach.
• Strong publication record or experience with writing grant applications.
• Highly motivated with excellent analytical, interpersonal, and communication skills.
• Excellent organizational skills and demonstrated ability to accurately complete detailed work.
• General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
• Experience with animal models of neurodegeneration.
• Ability to work independently and as part of a team with colleagues and collaborators.
• Ability to effectively communicate.
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Base pay is commensurate with experience.