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Radiology Clinical Trials Physician

Funding: Non-Industry
Research Focus: Autism (Pediatric)
Tittle: “A Longitudinal MRI Study of Infants at Risk for Autism”
Purpose: To better understand the brain behavior development in autism during Infancy and the long-term behavior of infants at high risk for autism (i.e., siblings of autistic individuals). The focus of the autism research is on the causes and best treatment of autism.

Funding:  Industry
Research Focus:  Brain (Adult)
Title“Pipeline device in treatment of brain aneurysms”
Purpose:  To prove that using the designated pipeline device in preferred aneurysms has best outcome

Funding: Industry
Research Focus: Brain (Adult)
Title“Randomized trial of coils in treatment of brain aneurysms”
Purpose:  Compare use between two types of coils to see which has best outcome

Funding: Non-Industry
Research Focus: Brain (Pediatric)
Title: “Darbepoetin Administration in Newborns Undergoing Cooling for Encephalopathy (DANCE)”
Purpose: To study newborn brain injury patterns using MRI techniques to assess severity of anatomic injury to improve treatment and patient care.  

Funding: Non-Industry
Research Focus: Brain (Pediatric)
Title “Spectroscopy Ratios as Markers of Normal Maturation”
Purpose:  The use of Spectroscopy Ratios could add another tool to help the radiologist diagnose brain anomalies in the neonatal age group with increase sensitivity and specificity

Funding: Non-Industry
Research Focus: Brain (Pediatric)
Title: “Neuroimaging in Early Onset Depression: Longitudinal Assessment of Brain”
Purpose:  To study the brain development and changes in the function and structure of brain networks which are key to emotion processing. Children with preschool onset of Major Depressive Disorder (PO-MDD) participate as they transition from school age to early adolescence.

Funding:  Industry
Research Focus:  Cancer (Breast)
Title:   “Phase Contrast Mammography”
Purpose:  Looking at a new type of imaging compared to standard specimen mammography.

Funding: Non- Industry
Research Focus:  Cancer (Adult)
Title“Comparison with Breast Tomo. and Conventional Mammography”
Purpose:  To prove the effectiveness of Breast Tomography for visualization of breast masses in comparison to Conventional Mammography.

Funding: Non-industry
Research Focus: Cancer (Adult)
Title“Role of Digital Breast Tomosynthesis in the Diagnostic Workup of Breast Asymmetries and Architectural Distortion”
Purpose: More efficient way to do diagnostic workup of common breast abnormalities, with less radiation dose. Also, this study will help clarify in which groups of patients DT may be useful in diagnostic workups.

Funding:  Industry
Research Focus:  Cancer (Adult)
Title:   “Staging and Diagnosis of cholangiocarcinoma with contrast enhanced MRI comparing Eovist vs. Gadolinium contrast agents”
Purpose:  To see if the liver shows better on a MRI with Eovist

Funding: Industry and Non-Industry
Research Focus: Cancer (Adult and Pediatrics)
Title: “Imaging Response Assessment Core”
Purpose:  To assess patient response to cancer treatment and ensure that imaging methods for response prediction or early response assessment are incorporated into therapeutic clinical trials.

Funding: Non-industry
Research Focus: Cancer (Adult)
Title: “Neuroendocrine tumors of the gastroenteropancreatic system: a retrospective correlative study of imaging and pathology with clinical outcome”
Purpose: CT and/or MR are commonplace in the workup of nonspecific symptoms as well as suspected carcinoid syndrome or malignancy. The results of this study will increase the radiologists’ awareness of the varied appearances of neuroendocrine tumor, leading to appropriate consideration of this entity in the differential diagnosis. This study may further increase the contribution of radiologic findings to patient care if a correlation between radiologic findings and tumor grading is determined, as tumor grading is a factor in disease prognosis.

Funding: Industry
Research Focus: Cancer (Adult)
Title: “Laser Ablation After Stereotactic Radiosurgery”
Purpose: information learned from this research study will benefit other patients with brain tumors in the future by helping us to learn how to better utilize available resources, including the NeuroBlate System, in their medical care.

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title “Intraoperative Brain Mapping Using Electrocorticography, Mapping Eloquent Cortex Using Resting State Cortical Physiology”
Purpose: These methods of analyzing brain activity may improve the efficiency and resolution of mapping methods by standard stimulation. It may help the surgeon find the region of interest more rapidly. It can also help provide information to detecting an area of the brain important for speech, motor movement, or other important thought related function not found with stimulation or not normally detectable with stimulation.

Funding: Non-industry
Research Focus: Cancer (Adult)
Title: “Cystic pancreatic neuroendocrine tumors: a retrospective study to identify unique imaging features compared to other cystic pancreatic neoplasms “
Purpose: Although only a fraction of pancreatic neuroendocrine tumors demonstrate a cystic appearance, the total number of these cases is expected to increase, since the incidence of neuroendocrine tumors has been increasing in recent decades. Through this study, we will identify CT and MR imaging features of cystic neuroendocrine tumors which will help distinguish this entity from other cystic pancreatic neoplasms, thereby improving the radiologists’ diagnostic ability

Funding: Non-industry
Research Focus:  Cancer (Adult)
Title: “Complication Rate for Liver Mass Biopsies: Comparison of Surface Lesions and Deep Lesions”
Purpose: Information gained from this study may be of benefit to other persons undergoing the same medical procedure

Funding: Non-industry
Research Focus: Cancer (Adult)
Title“Diffusion-weighted MRI for staging and predicting response in diffuse large b-cell lymphoma: pilot study”
Purpose: If this study shows that DW-MRI is useful, it could replace FDG-PET/CT in tumor assessment. MRI is non-invasive, uses no ionizing radiation, allows unlimited serial examination, is capable of high spatial resolution, is less expensive, and is more readily available.

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title: “Evaluation of Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)”
Purpose: This study will evaluate PET-MRI in patients with adenocarcinoma of the head of the pancreas being considered for surgery.

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title: “Early Post-transplant Contrast-enhanced Abdominal CT to Predict the Risk of Acute Graft-versus-host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation”
Purpose: To determine the feasibility and safety of using contrast in abdominal CT in the early post-transplant period

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title “Renal Mass Assessment with Diffusion MRI”
Purpose:  Unnecessary surgery will be avoided in patients with a high attenuation cyst.
Unnecessary surgery may also be avoided in other benign renal lesions.  The area needed for surgical resection on the malignant lesions may be better approximated with the diffusion imaging.

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title: “Assessing the utility of liver function tests as predictors of biliary enhancement with Gd-EOB-DTPA contrast”
Purpose: Society will benefit from having a study showing the relevance of elevated serum bilirubin and hepatic function on the excretion of Eovist contrast into the biliary system, which can aid in detecting disease such as hepatocellular carcinoma.

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title: “Retrospective Review of HCC/cirrhosis in a transplant population: 10+ years of experience”
Purpose: The benefits to society include better understanding of radiologic criteria for liver transplantation, improved organ allocation and better understanding of radiologic predictors of possible future tumor recurrence in the transplanted liver.

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title“Transarterial chemoembolization for the treatment of hepatocellular carcinoma”
Purpose:  This project may lead to a better understanding of the risks, true safety and efficacy of TACE in patients with hepatocellular carcinoma. We may also gain an understanding of outcomes that could influence the way in which limited organs are distributed. This will further our understanding of the role of TACE as a stand-alone treatment and as a bridge to transplant in patients with HCC.

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title“Single Center Review of a Seven Year Experience with Liver Cryoablation”
Purpose: This data will support that cryoablation is safe and effective and further define the potential complications and their incidence.

Funding:  Industry
Research Focus:  Cancer (Adult)
Title:   “PET/CT for diagnosing head and neck cancer”
Purpose: To compare results of PET/CT and other imaging with surgical treatment planning.

Funding:  Industry
Research Focus:  Cancer (Adult)
Title: “CT and MRI for diagnosis in liver cancer”
Purpose:  comparing CT and MRI to see how accurate they are in diagnosing liver cancer

Funding: Industry
Research focus:  Cancer (Adult)
Title: “Respective review of Extracolonic findings on CT Colonography”
Purpose:  Review of CT colonography data for determination of colonic findings

Funding: Industry
Research Focus:  Cancer (Adult)
Title“TheraSphere treatment in colon cancer – Mets to liver”
Purpose:  Evaluating TheraSphere treatment to liver in patients who have failed first line chemotherapy

Funding: Non-Industry
Research Focus: Cancer (Adult)
Title“Early report on the safety and efficacy of epirubicin for transarterial chemoembolization of hepatic tumors”
Purpose: The indirect benefit to participants/society is improved knowledge about management strategies of hepatic tumors and transarterial chemoembolization techniques.

Funding: Non-Industry
Research Focus: Cancer (Pediatric)
Title: “A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine in the Very High Risk Stratum   (AALL 1131)”
Purpose: This study evaluates multi pediatric cancer trials to investigate the diagnosis and disease management. 

Funding: Non-industry
Research Focus: Cancer (Pediatric)
Title: “Mathematical Modeling of Pediatric Pulmonary Nodules”
Purpose: This research is directed to establish noninvasive methods of using CT exams to differentiate between malignant and benign nodules. For children with small lung nodules, successful completion of this hypothesis would reduce the number of invasive surgical biopsies performed in this population while improving diagnostic accuracy.

Funding: Non-industry
Research Focus:  Cancer (Pediatric)
Title “Dose Reduction using Iterative Reconstruction Technologies in Pediatric CT”
Purpose:  The potential benefits are performing CT with a lower dose and thus, minimizing or obviating any potential cancer risk associated with CT.  The knowledge gained from this study should ultimately provide a method for us to achieve an "as low as reasonably achievable" CT practice.

Funding: Non-Industry
Research Focus: Cardiac (Adult)
Title: “Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA3CT)”
Purpose:  This study includes several centers working together to determine if doxycycline will be effective in treating abdominal aortic aneurysms in comparison to a placebo-treated control group.

Funding: Non-Industry
Research Focus: Cardiac (Pediatric)
Tittle: “Circulatory Support in Pediatric Heart Failure Patients Using the Infant Jarvik 2000”
Purpose: To understand the safety and benefits of the Infant Jarvik 2000 in pediatric patients with severe heart failure who require mechanical circulatory support.

Funding: Non-Industry
Research Focus: Cystic Fibrosis
Title: “Longitudinal Study of Ultrasound to Predict Cirrhosis in Cystic Fibrosis”
Purpose: This study evaluates sonography (also known as ultrasound) to predict cirrhosis in patients with cystic fibrosis.

Funding: Non-Industry
Research Focus: Education and Patient Care
Tittle: “Developing a curriculum for optimal use of radiation during fluoroscopic procedures” (Development of a Radiology Improvement Leader Training Course)
Purpose: The goal is to develop a curriculum to improve clinical services to the patients we serve. Radiologists use this curriculum to meet the demands of regulatory requirements while also addressing patient concerns about radiation use.

Funding: Non-Industry
Research Focus: Education and Patient Care
Title: “Improving team performance during the pre-procedure timeout”
Purpose: This study is focused on a better understanding of the needed checklists and pre-procedure checks to improve quality control and find any flaw that will lead to improved services.

Funding: Non-Industry
Research Focus: Education and Patient Care
Title: “Optimizing Radiation Use During Fluoroscopic Procedures”
Purpose: This study brings together four other Universities to develop standardized protocols for collecting radiation dose information. From this data they have begun to develop protocols needed to develop reference levels for the common x-ray procedures. 

Funding: Industry
Research focus: Education and Patient Care
Title“High Resolution Computed Radiography for Neonatal ICU infants”
Purpose: Optimize image quality to current imaging that is in use at St. Louis Children’s Hospital

Funding: Non-industry
Research Focus:  Education and Patient Care (Pediatric)
Title: “Trends in CT Scanning and Dose in the Pediatric Emergency”
Purpose: The potential benefits to society are that our results will help us identify a group of children who are more likely to undergo repeat CT based on clinical indications. By identifying this group, we can develop recommendations for imaging with another technique that does not use radiation. In those children who do need repeat CT, we can optimize the technique to ensure that these indicated scans are performed with the lowest possible radiation dose.

Funding: Non-Industry
Research Focus: Education and Patient Care
Title“Emergency Department Computed Tomography (CT) in Patients with Urinary Tract Infections”
Purpose:  1) Radiation dose awareness and radiation reduction. 2) Potentially more effective triage in select Emergency Department patients.

Funding: Non-Industry
Research Focus: Education and Patient Care
Title “Pharmacomechanical thrombolysis in patients with inferior vena cava filters.”
Purpose: Society will benefit from the study by having more information involving an invasive procedure in order to weigh risks and benefits.

Funding: Non-Industry
Research Focus: Education and Patient Care
Title: “Optimizing Radiation Use During Computed Tomography”
Purpose: This study uses data driven systems to balance the risks and benefits of Computed Tomography (CT).  Statistical tools are used to capture radiation information from CT, develop formulas to predict radiation dose in common CT exams, and communicate needs from the prediction data to the frontline teams assisting our patients.

Funding:  Non-Industry
Research Focus:  Education and Patient Care
Title“Patient satisfaction randomized trial for thyroidectomy patients who are scheduled for surgery”
Purpose:  To compare surgeon’s office visit regarding information on upcoming thyroid surgery with the information they receive from watching videos on same topic.

Funding: Non-Industry
Research Focus: Education and Patient Care
Title“Magnetic Resonance Imaging Sequence Optimization “
Purpose: distinct benefits can be obtained in future research that can lead to shorter acquisition times and, ultimately, reduced costs associated with the development and use of new medical therapies and treatments.

Funding:  Non-Industry
Research Focus:  Multiple Sclerosis
Title:   “Imaging with MS”
Purpose:  Develop better imaging for diagnosis of MS

Funding: Non-industry
Research Focus: Kidney (Adult)
Title“CT angiography findings in renal donors”
Purpose: By analyzing the radiological characteristics of the potential renal transplant and correlating these findings with the transplant recipient’s outcome, we will contribute to the development of radiological guidelines in live donor renal transplantation, as well as improve patient care.

Funding:  Industry
Research Focus:  Liver Disease
Title:   “Development of Comprehensive Liver MRI Protocol”
Purpose:  To develop a better way to examine the liver using MRI

Funding: Non-Industry
Research Focus: Liver (Adult)
Title“Effect of TIPS on clinical management of patients awaiting liver transplantation”
Purpose: This study may lead to potential benefits in the management of patients awaiting liver transplant


Funding:  Non-Industry
Research Focus:  Lung disease
Title“Lung disease using CT imaging for HIV patients”
Purpose:  Improve imaging tools for lung disease in HIV patients

Funding: Non-Industry
Research Focus: Neuro Development (Pediatric)
Title: “Longitudinal DTI study in Children Treated for Congenital Hydrocephalus”
Purpose: To use MRI to better understand injury and post-treatment recovery in children with hydrocephalus (HCP) also known as "water on the brain". This study will help identify children who will benefit the most from shunt surgery which is currently the most common surgical procedure performed in pediatric neurosurgery.

Funding:  Non-Industry
Research Focus:  Neuro Development (Pediatric)
Title:    “Congenital Hydrocephalus”
Purpose:  Serve as an Imaging Core to review MRIs collected from multiple other centers

Funding: Non-Industry
Research Focus: Neuro Development (Pediatric)
Title: “Paroxysmal and Progressive Neurological Disorders”
Purpose: By participating in this study, the subject may benefit from the additional images added to the MRI scan. The information from the scan may give the doctor new information about their condition that he/she might not get in any other way. This may include detecting new abnormalities or better defining the extent of abnormality that the subject has.

Funding: Non-Industry
Research Focus: Neuro Development (Pediatric)
Title: “Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes”
Purpose:  Hypoxic-ischemic encephalopathy (HIE), is a condition of reduced blood and oxygen flow to a baby's brain near the time of birth that can lead to neurologic disability. Cooling therapy (hypothermia) provides some protection. This trial will determine if the drug erythropoietin, given with hypothermia, is safe to use as a treatment that may further reduce the risk of neurologic disability.

Funding: Non-Industry
Research Focus:  Liver disease (Adults)
Title“MRI imaging for measuring fat in Non-Alcoholic liver disease”
Purpose:  Using MRI as a method for non-invasive liver fat measurement for adults with non-alcoholic liver disease

Funding:  Non-Industry
Research Focus:  Liver disease (Pediatric)
Title: “Comparison of drug vs. placebo for treatment in NAFLD in children”
Purpose:  To see if a delayed response drug for 52 weeks in comparison with a placebo improves the NAFLD in children

Funding:  Industry
Research Focus:  Pulmonary Embolisms
Title“Inferior Vena Cava device for treatment of Pulmonary Embolisms”
Purpose:  Evaluate safety and efficacy of retrievable IVC filter

Funding: Non-Industry
Research Focus: Sickle Cell Disease
Title: Familial Haploidentical T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease
Purpose: To improve the safety and outcome in children following stem cell transplantation from a family donor following removal of immune cells from donor stem cells. This will help us understand the rate of rejection (graft failure) in patients with high-risk Sickle Cell Disease.

Funding:  Industry
Research Focus:  Sickle Cell
Title“Donor Cell Transplant for Children with Sickle Cell”
Purpose:  Review MRIs from other sites as imaging core

Funding: Non-industry
Research Focus: Urinary (Pediatric)
Title: “Pediatric Voiding Cystourethrogram - Practice Quality Improvement and the Potential for Dose Reduction”
Purpose:  We are trying to practice "As Low as Reasonably Achievable" (ALARA) with regards to imaging in pediatric patients. By demonstrating no affect on image interpretation along with dose reduction demonstrates best practice. We can monitor ourselves to make sure we are continuing to practice ALARA. Reporting the results can serve as a baseline data for other hospitals nationally.

Funding: Non-Industry
Research Focus:  Vocal Cords
Title“MRI imaging in vocal cord paralysis”
Purpose:  Examine blood vessels in people with vocal cord paralysis using MRI